Hindered ureas as masked isocyanates: Facile carbamoylation of nucleophiles under neutral conditions

Angewandte Chemie - International Edition

Volumn 48, Issue 46, 2009, Pages 8721-8724

  Hutchby, Marc ^a   Houlden, Chris E ^a   Gair Ford, J ^c   Tyler, Simon N G ^c   Gagné, Michel R ^b   Lloyd Jones, Guy C ^a   Booker Milburn, Kevin I ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Carbamoylation; Isocyanates; Proton switch; Reaction mechanisms; Urea solvolysis

Indexed keywords

CARBAMOYLATION; FASTER RATES; IN-SITU; ISOCYANATES; NEUTRAL CONDITIONS; NUCLEOPHILIC SUBSTITUTIONS; REACTION MECHANISMS;

METABOLISM; PROTONS; SOLVENTS;

UREA;

ISOCYANIC ACID DERIVATIVE; SOLVENT; UREA;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; STRUCTURE ACTIVITY RELATION;

ISOCYANATES; MOLECULAR STRUCTURE; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 70350578527     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200904435     Document Type: Article

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