Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly

Nature Medicine

Volumn 15, Issue 10, 2009, Pages 1202-1207

  Yamada, Masami ^a   Yoshida, Yuko ^a   Mori, Daisuke ^a   Takitoh, Takako ^a   Kengaku, Mineko ^b   Umeshima, Hiroki ^b   Takao, Keizo ^c,d,e   Miyakawa, Tsuyoshi ^c,d,e   Sato, Makoto ^f   Sorimachi, Hiroyuki ^g   Wynshaw Boris, Anthony ^h   Hirotsune, Shinji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c FUJITA HEALTH UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^f UNIVERSITY OF FUKUI   (Japan)

^g TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ALLN; ALOXISTATIN; CALPAIN; CALPASTATIN; DYNEIN ADENOSINE TRIPHOSPHATASE; PLATELET ACTIVATING FACTOR ACETYLHYDROLASE ISOFORM 1B SUBUNIT 1; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AGYRIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CELL MIGRATION; CELL VACUOLE; CEREBELLUM; CONTROLLED STUDY; DISEASE MODEL; EMBRYO; FEMALE; FIBROBLAST; GENE EXPRESSION REGULATION; GENE REPRESSION; IN VIVO STUDY; MALE; MARE; MOUSE; NERVE CELL; NERVE CELL NECROSIS; NONHUMAN; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; PROGENY; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEINASE INHIBITION; RNA INTERFERENCE;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ANIMALS; CALPAIN; CELL MOVEMENT; CELLS, CULTURED; CEREBRAL CORTEX; CYSTEINE PROTEINASE INHIBITORS; DISEASE MODELS, ANIMAL; DYNEIN ATPASE; EMBRYO, MAMMALIAN; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LEUCINE; LEUPEPTINS; LISSENCEPHALY; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, NEUROLOGICAL; NEURONS; PHENOTYPE; PREGNANCY;

MUS;

EID: 70350571218     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2023     Document Type: Article

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