Desipramine induced changes in the norepinephrine transporter, α- and γ-synuclein in the hippocampus, amygdala and striatum

Neuroscience Letters

Volumn 467, Issue 2, 2009, Pages 86-89

  Jeannotte, Alexis M ^a   McCarthy, John G ^a   Sidhu, Anita ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Synuclein; Synuclein; Depression; Desipramine; Norepinephrine transporter; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; DESIPRAMINE; GAMMA SYNUCLEIN; NORADRENALIN TRANSPORTER;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; CORPUS STRIATUM; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; FRONTAL CORTEX; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; REGULATORY MECHANISM; TREATMENT DURATION;

ADRENERGIC UPTAKE INHIBITORS; ALPHA-SYNUCLEIN; AMYGDALA; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BETA-SYNUCLEIN; CORPUS STRIATUM; DESIPRAMINE; HIPPOCAMPUS; MALE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; ORGAN SPECIFICITY; RATS; RATS, INBRED WKY; RATS, WISTAR;

EID: 70350569846     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.10.010     Document Type: Article

References (28)

1. Allain H., Schuck S., and Mauduit N. Depression in Parkinson's disease. Br. Med. J. 320 (2000) 1287-1288
2. 3H]-nisoxetine autoradiography. Brain Res. 582 (1992) 208-214
3. Braak E., Sandmann-Keil D., Rub U., Gai W.P., de Vos R.A., Steur E.N., Arai K., and Braak H. Alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei. Acta Neuropathol. (Berl.) 101 (2001) 195-201
4. Braak H., Del Tredici K., Rub U., de Vos R.A., Steur E.N., and Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24 (2003) 197-211
5. Clayton D.F., and George J.M. Synucleins in synaptic plasticity and neurodegenerative disorders. J. Neurosci. Res. 58 (1999) 120-129
6. Folstein S.E., Peyser C.E., Starkstein S.E., and Folstein M.F. Subcortical triad of Huntington's disease-a model for a neuropathology of depression, dementia, and dyskinesia. In: Carrel B.J., and Barrett J.E. (Eds). Psychopathology and the Brain (1991), Raven, New York 65-75
7. Gould G.G., Pardon M.C., Morilak D.A., and Frazer A. Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems. Neuropsychopharmacology 28 (2003) 1633-1641
8. Hebert C., Habimana A., Elie R., and Reader T.A. Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study. Neurochem. Int. 38 (2001) 63-74
9. Jeannotte A.M., and Sidhu A. Regulated interactions of the norepinephrine transporter by the actin and microtubule cytoskeletons. J. Neurochem. 105 (2008) 1668-1682
10. Jeannotte A.M., and Sidhu A. Regulation of the norepinephrine transporter by alpha-synuclein-mediated interactions with microtubules. Eur. J. Neurol. 26 (2007) 1509-1520
11. Jeannotte A.M., McCarthy J.G., Redei E.E., and Sidhu A. Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression. Neuropsychopharmacology 34 (2009) 987-998
12. Ji H., Liu Y.E., Jia T., Wang M., Liu J., Xiao G., Joseph B.K., Rosen C., and Shi Y.E. Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res. 57 (1997) 759-764
13. Jia T., Liu Y.E., Liu J., and Shi Y.E. Stimulation of breast cancer invasion and metastasis by synuclein gamma. Cancer Res. 59 (1999) 742-747
14. Klimek V., Stockmeier C., Overholser J., Meltzer H.Y., Kalka S., Dilley G., and Ordway G.A. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J. Neurosci. 17 (1997) 8451-8458
15. Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., Przuntek H., Epplen J.T., Schols L., and Reiss O. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 18 (1998) 106-108
16. Lavedan C., Leroy E., Dehejia A., Buchholtz S., Dutra A., Nussbaum R.L., and Polymeropoulos M.H. Identification, localization and characterization of the human gamma-synuclein gene. Hum. Genet. 103 (1998) 106-112
17. Liu H., Liu W., Wu Y., Zhou Y., Xue R., Luo C., Wang L., Zhao W., Jiang J.D., and Liu J. Loss of epigenetic control of synuclein-gamma gene as a molecular indicator of metastasis in a wide range of human cancers. Cancer Res. 65 (2005) 7635-7643
18. McHugh P.R. The neuropsychiatry of basal ganglia disorders. Neuropsychiatr. Neuropsychol. Behav. Neurol. 2 (1989) 239-247
19. Moussa C.E., Wersinger C., Rusnak M., Tomita Y., and Sidhu A. Abnormal migration of human wild-type alpha-synuclein upon gel electrophoresis. Neurosci. Lett. 371 (2004) 239-243
20. Ostrerova N., Petrucelli L., Farrer M., Mehta N., Choi P., Hardy J., and Wolozin B. Alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. J. Neurosci. 19 (1999) 5782-5791
21. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., and Nussbaum R.L. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
22. Sidhu A., Wersinger C., and Vernier P. Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse?. FASEB J. 18 (2004) 637-647
23. Singleton A.B., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., hulihan M., Peuralinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Maraganore D., Adler C., Cookson M.R., Muenter M., Baptista M., Miller D., Blancato J., Hardy J., and Gwinn-Hardy K. Alpha-Synuclein locus triplication causes Parkinson's disease. Science 302 (2003) 841
24. Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q., Jakes R., and Goedert M. Alpha-synuclein in Lewy bodies. Nature 388 (1997) 839-840
25. Swerdlow N.R., and Koob G.F. Dopamine, schizophrenia, mania and depression: toward a unified hypothesis ofcortico-striato-pallido-thalamic function. Behav. Brain Sci. 10 (1987) 197-245
26. Veazey C., Aki S.O., Cook K.F., Lai E.C., and Kunik M.E. Prevalence and treatment of depression in Parkinson's disease. J. Neuropsychiatr. Clin. Neurosci. 17 (2005) 310-323
27. Videbech P., and Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am. J. Psychiatry 161 (2004) 1957-1966
28. Wersinger C., Jeannotte A., and Sidhu A. Attenuation of the norepinephrine transporter activity and trafficking via interactions with alpha-synuclein. Eur. J. Neurol. 24 (2006) 3141-3152