A new paraneoplastic encephalomyelitis autoantibody reactive with the axon initial segment

Neuroscience Letters

Volumn 467, Issue 2, 2009, Pages 169-172

  Shams'ili, Setareh ^a   de Leeuw, Bertie ^a   Hulsenboom, Esther ^a   Jaarsma, Dick ^a   Smitt, Peter Sillevis ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

IV spectrin; Axon initial segment; Paraneoplastic encephalomyelitis; UbcH6; UBE2E1

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; ETOPOSIDE; SPECTRIN; UBIQUITIN CONJUGATING ENZYME E2;

AGED; ANIMAL TISSUE; ANTIGEN ANTIBODY REACTION; ARTICLE; CASE REPORT; CLINICAL FEATURE; ENCEPHALOMYELITIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG SMALL CELL CANCER; MALE; NERVE FIBER; NONHUMAN; NUCLEOTIDE SEQUENCE; PARANEOPLASTIC ENCEPHALOMYELITIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RANVIER NODE; RAT;

AGED; ANIMALS; AUTOANTIBODIES; AXONS; BRAIN; HUMANS; LUNG NEOPLASMS; MALE; NERVE TISSUE PROTEINS; PARANEOPLASTIC SYNDROMES, NERVOUS SYSTEM; RATS; SMALL CELL LUNG CARCINOMA; SPECTRIN; UBIQUITIN-CONJUGATING ENZYMES;

EID: 70350567127     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.10.031     Document Type: Article

References (17)

1. Berghs S., Aggujaro D., Dirkx Jr. R., Maksimova E., Stabach P., Hermel J.M., Zhang J.P., Philbrick W., Slepnev V., Ort T., and Solimena M. betaIV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous system. J. Cell Biol. 151 (2000) 985-1002
2. Berghs S., Ferracci F., Maksimova E., Gleason S., Leszczynski N., Butler M., De Camilli P., and Solimena M. Autoimmunity to beta IV spectrin in paraneoplastic lower motor neuron syndrome. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 6945-6950
3. Buckanovich R.J., Posner J.B., and Darnell R.B. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Neuron 11 (1993) 657-672
4. Burger A.M., and Seth A.K. The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications. Eur. J. Cancer 40 (2004) 2217-2229
5. Coesmans M., Sillevis Smitt P.A., Linden D.J., Shigemoto R., Hirano T., Yamakawa Y., Van Alphen A.M., Luo C., Van Der Geest J.N., Kros J.M., Gaillard C.A., Frens M.A., and De Zeeuw C.I. Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies. Ann. Neurol. 53 (2003) 325-336
6. Dalmau J., Furneaux H.M., Gralla R.J., Kris M.G., and Posner J.B. Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer-a quantitative western blot analysis. Ann. Neurol. 27 (1990) 544-552
7. Fang S., and Weissman A.M. A field guide to ubiquitylation. Cell. Mol. Life Sci. 61 (2004) 1546-1561
8. Graus F., Delattre J.Y., Antoine J.C., Dalmau J., Giometto B., Grisold W., Honnorat J., Smitt P.S., Vedeler C., Verschuuren J.J., Vincent A., and Voltz R. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J. Neurol. Neurosurg. Psychiatry 75 (2004) 1135-1140
9. Henson R.A., Hoffman H.L., and Urich H. Encephalomyelitis with carcinoma. Brain 88 (1965) 449-464
10. Jaarsma D., Rognoni F., van Duijn W., Verspaget H.W., Haasdijk E.D., and Holstege J.C. CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations. Acta Neuropathol. (Berl.) 102 (2001) 293-305
11. Lacas-Gervais S., Guo J., Strenzke N., Scarfone E., Kolpe M., Jahkel M., De Camilli P., Moser T., Rasband M.N., and Solimena M. BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segments. J. Cell Biol. 166 (2004) 983-990
12. Manley G.T., Sillevis Smitt P.A.E., Dalmau J., and Posner J.P. Hu antigens: reactivity with Hu antibodies, tumor expression, and major immunogenic sites. Ann. Neurol. 38 (1995) 102-110
13. Nyman T.A., Matikainen S., Sareneva T., Julkunen I., and Kalkkinen N. Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes. Eur. J. Biochem. 267 (2000) 4011-4019
14. Ogawa Y., and Rasband M.N. The functional organization and assembly of the axon initial segment. Curr. Opin. Neurobiol. 18 (2008) 307-313
15. Palay S.L., Sotelo C., Peters A., and Orkand P.M. The axon hillock and the initial segment. J. Cell Biol. 38 (1968) 193-201
16. Sillevis Smitt P., Grefkens J., De Leeuw B., Van Den Bent M., Van Putten W., Hooijkaas H., and Vecht C. Survival and outcome in 73 anti-Hu positive patients with paraneoplastic encephalomyelitis/sensory neuronopathy. J. Neurol. 249 (2002) 745-753
17. Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J., and Marra M.A. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 16899-16903