Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-Phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP Inhibitors

Chemical Biology and Drug Design

Volumn 74, Issue 6, 2009, Pages 535-546

  Gooyit, Major ^a   Lee, Mijoon ^a   Hesek, Dusan ^a   Boggess, Bill ^a   Oliver, Allen G ^a   Fridman, Rafael ^b   Mobashery, Shahriar ^a   Chang, Mayland ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Enzyme inhibition; Gelatinase; Metabolism

Indexed keywords

2(4 PHENOXYPHENYLSULFONYLMETHYL)THIIRANE; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG METABOLISM; DRUG OXIDATION; DRUG SYNTHESIS; DRUG TRANSFORMATION; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY; ENZYME INHIBITORS; GELATINASES; HETEROCYCLIC COMPOUNDS, 1-RING; KINETICS; MASS SPECTROMETRY; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICROSOMES, LIVER; MOLECULAR CONFORMATION; OXIDATION-REDUCTION; RATS; STEREOISOMERISM; SULFONES;

EID: 70350544040     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00898.x     Document Type: Article

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