New insights into cardiac aging

Circulation

Volumn 120, Issue 17, 2009, Pages 1654-1656

  Muslin, Anthony J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Autophagy; Editorials; Free radicals; Insulin; Myocardium

Indexed keywords

BETA GALACTOSIDASE; CHLOROQUINE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LIPOFUSCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B BETA; PROTEIN TORC1; RAPAMYCIN; SIRTUIN 3; SOMATOMEDIN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

AGE 1 GENE; AGING; AUTOPHAGY; CAENORHABDITIS ELEGANS; CALORIC INTAKE; CALORIC RESTRICTION; CARDIAC AGING; CELL AGING; DAF 2 GENE; EDITORIAL; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE; HEART FUNCTION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; LIFE EXTENSION; LONGEVITY; LOSS OF FUNCTION MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AGING; ANIMALS; HUMANS; INSULIN; MYOCARDIUM; SIGNAL TRANSDUCTION;

EID: 70350544014     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.109.905356     Document Type: Editorial

References (18)

1. Weindruch R, Walford RL, Fligiel S, Guthrie D. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr. 1986;116:641-654
2. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997;277:942-946
3. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M. Suppression of aging in mice by the hormone Klotho. Science. 2005;309:1829-1833
4. Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 2003;299:572-574
5. Morris JZ, Tissnebaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapose in Caenorhabditis elegans. Nature. 1996;382:536-539
6. Cheatham B, Kahn CR. Insulin action and the insulin signaling network. Endocrine Rev. 1995;16:117-142
7. Debosch BJ, Muslin AJ. Insulin signaling pathways and cardiac growth. J Mol Cell Card. 2008;44:855-864
8. Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 1999;13: 1438-1452
9. Manning BD, Cantley LC. United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochem Soc Trans. 2003;31:573-578
10. Inoki K, Guan KL. Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. Hum Mol Genet. 2009;18: R94-R100
11. Burgering BM. A brief introduction to FOXOlogy. Oncogene. 2008;27: 2258-2262
12. Salih DA, Brunet A. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol. 2008;20: 126-136
13. Inuzuka Y, Okuda J, Kawashima T, Kato T, Niizuma S, Tamaki Y, Iwanaga Y, Yoshida Y, Kosugi R, Watanabe-Maeda K, Machida Y, Tsuji S, Aburatani H, Izumi T, Kita T, Shioi T. Suppression of phosphoinosi-tide 3-kinase prevents cardiac aging in mice. Circulation. 2009;120: 1695-1703
14. Jung T, Bader N, Grune T. Lipofuscin: formation, distribution, and metabolic consequences. Ann N Y Acad Sci. 2007;1119:97-111
15. Moore WA, Davey VA, Weindruch R, Walford R, Ivy GO. The effect of caloric restriction on lipofuscin accumulation in mouse brain with age. Gerontology. 1995;41(suppl 2):173-185
16. Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, Kleijer WJ, DiMaio D, Hwang ES. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell. 2006;5:187-195
17. Yen WL, Klionsky DJ. How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda). 2008;23:248-262
18. Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest. 2009; 119:2758-2771