Isovaline causes inhibition by increasing potassium conductance in thalamic neurons

Neuroscience

Volumn 164, Issue 3, 2009, Pages 1235-1243

  Cooke, J E ^a   Mathers, D A ^a   Puil, E ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

analgesic; glycine receptor; nociception; potassium conductance; R isovaline; thalamus

Indexed keywords

AMINO ACID; BARIUM ION; CALCIUM ION; CESIUM ION; CHLORIDE ION; GLYCINE; GLYCINE RECEPTOR; ISOVALINE; NEUROTRANSMITTER; POTASSIUM ION; STRYCHNINE; TETRODOTOXIN;

ACTION POTENTIAL; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN TISSUE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXCITATION; HYPERPOLARIZATION; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PAIN; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; RAT STRAIN; RECORDING; THALAMUS VENTRAL NUCLEUS; TISSUE SECTION; VOLTAGE CLAMP; WHOLE CELL;

ACTION POTENTIALS; ANALGESICS; ANIMALS; ANIMALS, NEWBORN; CALCIUM SIGNALING; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCINE; NEURAL INHIBITION; NEURONS; ORGAN CULTURE TECHNIQUES; PAIN; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLYCINE; VALINE; VENTRAL THALAMIC NUCLEI;

EID: 70350526966     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.08.045     Document Type: Article

References (24)

1. +-induced anomalous rectification in squid giant axons. J Gen Physiol 50 (1966) 491-503
2. Beyer C., Banas C., Gomora P., and Komisaruk B.R. Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids. Pharmacol Biochem Behav 29 (1988) 73-78
3. Brückner H., Becker D., Gams W., and Degenkolb T. Aib and iva in the biosphere: neither rare nor necessarily extraterrestrial. Chem Biodivers 6 (2009) 38-56
4. Brunton J., and Charpak S. μ-Opioid peptides inhibit thalamic neurons. J Neurosci 18 (1998) 1671-1678
5. Christensen H.N. Intestinal absorption with special reference to amino acids. Gastroenterology 21 (1962) 37-42
6. Ghavanini A.A., Mathers D.A., Kim H.S., and Puil E. Distinctive glycinergic currents with fast and slow kinetics in thalamus. J Neurophysiol 95 (2006) 3438-3448
7. Ghavanini A.A., Mathers D.A., and Puil E. Glycinergic inhibition in thalamus revealed by synaptic receptor blockade. Neuropharmacology 49 (2005) 338-349
8. Golshani P., Warren R.A., and Jones E.G. Progression of change in NMDA, non-NMDA, and metabotropic glutamate receptor function at the developing corticothalamic synapse. J Neurophysiol 80 (1998) 143-154
9. Guilbaud G., Peschanski M., Gautron M., and Binder D. Neurones responding to noxious stimulation in VB complex and caudal adjacent regions in the thalamus of the rat. Pain 8 (1980) 303-318
10. Khandwala H., and Loomis C.W. Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat. Pain 77 (1998) 87-95
11. Kvenvolden K.A., Lawless J., Pering K., Peterson E., Flores J., Ponnamperuma C., Kaplan I., and Moore C. Evidence for extraterrestrial amino-acids and hydrocarbons in the Murchison meteorite. Nature 228 (1970) 923-926
12. MacLeod BA, Wang JTC, Sang Mook Lee IL, Ries CR, Schwartz SK, Puil E (in press) Analgesic properties of the novel amino acid, isovaline. Anesth Analg, in press.
13. McCormick D.A., and Pape H.-C. Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J Physiol 431 (1990) 291-318
14. Miraucourt L.S., Dallel R., and Voisin D.L. Glycine inhibitory dysfunction turns touch into pain through PKCgamma interneurons. PLoS One 2 (2007) e1116
15. Ocana M., Cendán C.M., Cobos E.J., Entrena J.M., and Baeyens J.M. Potassium channels and pain: present realities and future opportunities. Eur J Pharmacol 500 (2004) 203-219
16. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 2nd ed. (1987), Academic Press, New York
17. B receptors on CA1 pyramidal cells of rat hippocampal slices. J Neurophysiol 76 (1996) 69-80
18. Raap J., Erkelens K., Ogrel A., Skladnev D.A., and Brückner H. Fungal biosynthesis of non-ribosomal peptide antibiotics and alpha, alpha-dialkylated amino acid constituents. J Pept Sci 11 (2005) 331-338
19. Racz I., Schutz B., Abo-Salem O.M., and Zimmer A. Visceral, inflammatory and neuropathic pain in glycine receptor α 3-deficient mice. Neuroreport 16 (2005) 2025-2028
20. Ries C.R., and Puil E. Ionic mechanism of isoflurane's actions on thalamocortical neurons. J Neurophysiol 81 (1999) 1802-1809
21. Wan X., Mathers D.A., and Puil E. Pentobarbital modulates intrinsic and GABA-receptor conductances in thalamocortical inhibition. Neuroscience 121 (2003) 947-958
22. Yaksh T.L. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain 37 (1989) 111-123
23. Zeilhofer H.U. The glycinergic control of spinal pain processing. Cell Mol Life Sci 62 (2005) 2027-2035
24. Zhao M., and Bada J.L. Extraterrestrial amino acids in cretaceous/tertiary boundary sediments at Stevns Klint, Denmark. Nature 339 (1989) 463-465