Ionic mechanism of isoflurane's actions on thalamocortical neurons

Journal of Neurophysiology

Volumn 81, Issue 4, 1999, Pages 1802-1809

  Ries, Craig R ^a   Puil, Ernest ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLIBENCLAMIDE; ISOFLURANE; POTASSIUM CHANNEL;

ACTION POTENTIAL; ANESTHESIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; HYPERPOLARIZATION; ION CONDUCTANCE; MEMBRANE CONDUCTANCE; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SPIKE; STEADY STATE; THALAMOCORTICAL TRACT; VOLTAGE CLAMP;

EID: 0033019645     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1999.81.4.1802     Document Type: Article

References (36)

1. BERG-JOHNSEN, J. AND LANGMOEN, I. A. Mechanisms concerned in the direct effect of isoflurane on rat hippocampal and human neocortical neurons. Brain Res. 507: 28-34, 1990.
2. + conductance: a possible common mechanism for sedative-hypnotic drug action. Can. J. Physiol. Pharmacol. 63: 831-837, 1985.
3. CASON, B. A., SHUBAYEV, I., AND HICKEY, R. F. Blockade of adenosine triphosphate-sensitive potassium channels eliminates isoflurane-induced coronary artery vasodilation. Anesthesiology 81: 1245-1255, 1994.
4. +-dependent inhibitory postsynaptic potentials evoked by interneurons of the rat lateral geniculate nucleus. J. Physiol. (Lond.) 399: 153-176, 1988.
5. EL-BEHEIRY, H. AND PUIL, E. Anaesthetic depression of excitatory synaptic transmission in neocortex. Exp. Brain Res. 77: 87-93, 1989a.
6. EL-BEHEIRY, H. AND PUIL, E. Postsynaptic depression induced by isoflurane and althesin in neocortical neurons. Exp. Brain Res. 75: 361-368, 1989b.
7. ERDEMLI, G. AND KRNJEVIĆ, K. Guanosine diphosphate is required for activation of a glyburide, ATP and cromakalim-sensitive outward current in rat hippocampal neurones. Neuroreport 5: 1362-1364, 1994.
8. EYRING, E., WOODBURY, J. W., AND D'ARRIGO, J. S. A molecular mechanism of general anestheisa. Anesthesiology 38: 415-424, 1973.
9. HUTCHEON, B., MIURA, R. M., YAROM, Y., AND PUIL, E. Low-threshold calcium current and resonance in thalamic neurons: a model of frequency preference. J. Neurophysiol. 71: 583-594, 1994.
10. + conductance in guinea-pig hippocampal pyramidal cells maintained in vitro. Br. J. Pharmacol. 84: 833-841, 1985.
11. - currents in cultured rat hippocampal neurones by three volatile anaesthetics. J. Physiol. (Lond.) 449: 279-293, 1992.
12. ATP) channels. Anesthesiology 85: 794-807, 1996.
13. KRNJEVIĆ, K. Central actions of general anaesthetics. In: Molecular Mechanisms in General Anaesthesia, edited by M. J. Halsey, R. A. Millar, and J. A. Sutton. New York: Churchill Livingstone, 1974, p. 65-89.
14. KRNJEVIĆ, K. AND LEBLOND, J. Changes in membrane currents of hippocampal neurons evoked by brief anoxia. J. Neurophysiol. 62: 15-30, 1989.
15. KRNJEVIĆ, K. AND PUIL, E. Cellular mechanisms of general anesthesia. In: Principles of Medical Biology. Greenwich, CT: JAI, 1997, p. 811-828.
16. LEE, A. G. Model for action of local anaesthetics. Nature 262: 545-548, 1976.
17. LILLIE, R. S. Protoplasmic Action and Nervous Action. Chicago, IL: Univ. of Chicago Press, 1923.
18. LITTLE, H. J. How has molecular pharmacology contributed to our understanding of the mechanism(s) of general anesthesia? Pharmacol. Ther. 69: 37-58, 1996.
19. MACIVER, M. B. AND KENDIG, J. J. Anesthetic effects on resting membrane potential are voltage-dependent and agent-specific. Anesthesiology 74: 83-88, 1991.
20. MEYER, H. H. Welche Eigenschafte der Anästhetica bedingt ihre narkotische Wirkung? Naunyn Schmiedebergs Arch. Pharmacol. 42: 109-118, 1899.
21. MIU, P. AND PUIL, E. Isoflurane-induced impairment of synaptic transmission in hippocampal neurons. Exp. Brain Res. 75: 354-360, 1989.
22. NICOLL, R. A. AND MADISON, D. V. General anesthetics hyperpolarize neurons in the vertebrate central nervous system. Science 217: 1055-1057, 1982.
23. OVERTON, E. Studien über die Narkose, zugleich ein Beitrag zur allgemeiner Pharmakologie. Jena, Germany: Fischer, 1901.
24. +. channels in cultured rat hippocampal neurons: activation by cromakalim and energy-depleting conditions. Mol. Pharmacol. 40: 308-315, 1991.
25. PUIL, E. AND EL-BEHEIRY, H. Anaesthetic depression of transmitter actions in neocortex. Br. J. Pharmacol. 101: 61-66, 1990.
26. RIES, C. R. AND PUIL, E. Mechanism of anesthesia revealed by shunting actions of isoflurane on thalamocortical neurons. J. Neurophysiol. 81: 1795-1801, 1999.
27. SEEMAN, P. AND ROTH, S. General anesthetics expand cell membranes at surgical concentrations. Biochim. Biophys. Acta 255: 171-177, 1972.
28. SPRUSTON, N., JAFFE, D. B., WILLIAMS, S. H., AND JOHNSTON, D. Voltage-and space-clamp errors associated with the measurement of electrotonically remote synaptic events. J. Neurophysiol. 70: 781-802, 1993.
29. STEVENS, D. R. AND COTMAN, C. W. Excitatory actions of tetrahydro-9-aminoacridine (THA) on hippocampal pyramidal neurons. Neurosci. Lett. 79: 301-305, 1987.
30. SUGIYAMA, K., MUTEKI, T., AND SHIMOJI, K. Halothane-induced hyperpolarization and depression of postsynaptic potentials of guinea pig thalamic neurons in vitro. Brain Res. 576: 97-103, 1992.
31. SUTOR, B. AND HABLITZ, J. J. Influence of barium on rectification in rat neocortical neurons. Neurosci. Lett. 157: 62-66, 1993.
32. A receptor/chloride channel complex in anesthesia. Anesthesiology 78: 757-776, 1993.
33. TENNIGKEIT, F., RIES, C. R., SCHWARZ, D.W.F., AND PUIL, E. Isoflurane attenuates resonant responses of auditory thalamic neurons. J. Neurophysiol. 78: 591-596, 1997.
34. Ca currents by internally applied gluconate in rat hippocampal pyramidal neurones. Pflügers Arch. 433: 343-350, 1997.
35. WINEGAR, B. D., OWEN, D. F., YOST, S., FORSAYETH, J. R., AND MAYERI, E. Volatile general anesthetics produce hyperpolarization of Aplysia neurons by activation of a discrete population of baseline potassium channels. Anesthesiology 85: 889-900, 1996.
36. ZUCKER, J. R. ATP-sensitive potassium channel agonists do not alter MAC for isoflurane in rats. Anesthesiology 76: 560-563, 1992.