A study of metal concentrations and metallothionein binding capacity in liver, kidney and brain tissues of three Arctic seal species

Science of the Total Environment

Volumn 407, Issue 24, 2009, Pages 6166-6172

  Sonne, Christian ^a   Aspholm, Ole ^b   Dietz, Rune ^a   Andersen, Steen ^c   Berntssen, Marc H G ^d   Hylland, Ketil ^b,e  

^a NATIONAL ENVIRONMENTAL RESEARCH INSTITUTE   (Denmark)

^b NORWEGIAN INSTITUTE FOR WATER RESEARCH   (Norway)

^c HuntersSciencecom   (Denmark)

^d INSTITUTE OF MARINE RESEARCH   (Norway)

^e UNIVERSITY OF OSLO   (Norway)

Author keywords

Arctic; Brain; Cadmium; Copper; Kidney; Liver; Mercury; Metallothionein; MT; Seal; Zinc

Indexed keywords

ARCTIC; KIDNEY; MERCURY; METALLOTHIONEIN; MT;

BRAIN; CADMIUM; CONCENTRATION (PROCESS); COPPER; HISTOLOGY; LIVER; MERCURY (METAL); TELLURIC PROSPECTING; TOXIC MATERIALS; ZINC;

METALS;

CADMIUM; COPPER; MERCURY; METALLOTHIONEIN; ZINC;

BIOACCUMULATION; BIOMARKER; BIOMONITORING; CONCENTRATION (COMPOSITION); ENVIRONMENTAL QUALITY; HEAVY METAL; METALLOTHIONEIN; PINNIPED; POLLUTION EXPOSURE; TOXICITY; TOXICITY TEST;

ANIMAL HEALTH; ANIMAL TISSUE; ARCTIC; ARTICLE; BRAIN LEVEL; CONCENTRATION (PARAMETERS); CONTAMINATED ANIMAL; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL PROTECTION; GREENLAND; HEAVY METAL POISONING; KIDNEY; LIVER LEVEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SEAL; SPECIES DIFFERENCE; TISSUE DISTRIBUTION; TISSUE LEVEL; UPREGULATION;

ANIMAL STRUCTURES; ANIMALS; ARCTIC REGIONS; BRAIN; ENVIRONMENTAL MONITORING; KIDNEY; LIVER; METALLOTHIONEIN; METALS, HEAVY; PHOCA; PINNIPEDIA; SEALS, EARLESS; WATER POLLUTANTS, CHEMICAL;

ARCTIC; ARCTIC OCEAN; BARENTS SEA; GREENLAND; WEST GREENLAND;

CYSTOPHORA (MAMMALIA); CYSTOPHORA CRISTATA; PHOCA GROENLANDICA; PHOCA HISPIDA;

EID: 70350521443     PISSN: 00489697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2009.08.029     Document Type: Article

References (67)

1. Afonne O.J., Orisakwe O.E., Obi E., Dioka C.E., and Ndubuka G.I. Nephrotoxic actions of low-dose mercury in mice: protection by zinc. Arch Environ Health 57 (2002) 9-102
2. AMAP. 1998. Arctic Monitoring and Assessment Programme: AMAP Assessment Report - Arctic Pollution Issues. Oslo: 1998 (available on-line: www.amap.no).
3. AMAP. 2004. Arctic Monitoring and Assessment Programme: AMAP Assessment 2002 - Persistent Organic Pollutants in the Arctic. Oslo: 2004 (available on-line: www.amap.no).
4. AMAP. 2005. Arctic Monitoring and Assessment Programme: AMAP Assessment 2002 - Heavy Metals in the Arctic. Oslo: 2005 (available on-line: www.amap.no).
5. Banerjee S., and Bhattacharya S. Histopathology of kidney of channa-punctatus exposed to chronic nonlethal level of elsan, mercury and ammonia. Ecotoxicol Environ Saf 29 (1994) 265-275
6. Basu N., Scheuhammer A.M., Sonne C., Letcher R.J., and Dietz R. Is dietary mercury of neurotoxicological concern to wild polar bears (Ursus maritimus)?. Environ Toxicol Chem 28 (2009) 133-140
7. Bergman A., Bergstrand A., and Bignert A. Renal lesions in Baltic grey seals (Halichoerus grypus) and ringed seals (Phoca hispida botnica). Ambio 30 (2001) 397-409
8. Berntssen M.H.G., Hylland K., Wendelaar Bonga S.E., and Maage A. Toxic levels of dietary copper in Atlantic salmon (Salmo salar L.) parr. Aquat Toxicol 46 (1999) 87-99
9. Brdicka R. Polorographic studies with the presence of cobalt salts in 20 ammoniacal solutions of ammonium chloride. Collect Czechoslov Chem Commun 5 (1933) 112-118
10. Bremner I., and Beattie J.H. Metallothioneins and the trace elements. Annu Rev Nutr 10 (1990) 63-83
11. Brunborg L.A., Graff I.E., Frøyland L., and Julshamn K. Levels of non-essential elements in muscle from harp seal (Phagophilus groenlandicus) and hooded seal (Cystophora cristata) caught in the Greenland Sea area. Sci Total Environ 366 (2006) 784-798
12. Cai W., and Stillman M.J. Hg18-metallothionein. J Am Chem Soc 110 (1988) 7872-7873
13. Churg J., Bernstein J., and Glassock R.J. Renal disease. Classification and atlas of glomerular diseases (1995), Igaku-Shoin, New York
14. Confer A.W., and Panciera R.J. The urinary system. In: Carlton W.W., and McGavin M.D. (Eds). Thomson's special Veterinary Pathology. 2nd edn. (1995), Mosby - Year Book, Inc., St. Louis, Missouri, USA 209-246
15. Cotran R.S., Kumar V., and Collins T. Robbins pathologic basis of disease (1999), WB Saunders Company, Philadelphia
16. Das K., Groof A.D., Jauniaux T., and Bouquegneau J.M. Zn, Cu, Cd and Hg binding to metallothioneins in harbour porpoises (Phocoena phocoena) from the southern North Sea. BMC Ecol 6 (2006) 2
17. Dietz R., Heide-Jørgensen M.P., Härkönen T., Teilmann J., and Valentin N. Age determination of European harbour seal, Phoca vitulina L. Sarsia 76 (1991) 17-21
18. Dietz R., Rigét F.F., and Johansen P. Lead, cadmium, mercury and selenium in Greenland marine animals. Sci Total Environ 186 (1996) 67-93
19. Dietz R., Johansen P., Rigét F.F., and Asmund G. Data on heavy metals from Grenland before 1994: contaminants in the Greenland Marine environment. In: Aarkrog A., Aastrup P., Asmund G., Bjerregaard P., Boertmann D., Carlsen L., Christensen J., Cleemann M., Dietz R., Fromberg A., Storr-Hansen E., Heidam N.Z., Johansen P., Larsen H., Paulsen G.B., Petersen H., Pilegaard K., Poulsen M.E., Pritzl G., Rigét F.F., Skov H., Spliid H., Weihe P., and Wåhlin P. (Eds). AMAP Greenland 1994-1996. Environmental Project No. 356 (1997), Ministry of Environment and Energy, Danish Environmental Protection Agency, Copenhagen 247-350 792 pp.
20. Dietz R., Nørgaard J., and Hansen J.C. Have arctic marine mammals adapted to high cadmium levels?. Mar Pollut Bull 36 (1998) 490-492
21. Dietz R., Paludan-Müller P., Thye Agger C., and Nielsen C.O. Cadmium, mercury, zinc and selenium in ringed seals (Phoca hispida) from Greenland water. NAMMCO Scientific Contributions vol. 1 (1998) 242-273
22. Dietz R., Rigét F.F., and Born E.W. An assessment of selenium to mercury in Greenland marine animals. Sci Total Environ 245 (2000) 15-24
23. Dietz R., Riget F.F., and Born E.W. Geographical differences of zinc, cadmium, mercury and selenium in polar bears (Ursus maritimus) from Greenland. Sci Total Environ 245 (2000) 25-48
24. Elinder C.G., and Järup L. Cadmium and health risks: recent findings. Ambio 5 (1996) 370-373
25. Elsenhans B., Schüller N., Schümann K., and Forth W. Oral and subcutaneous administration of cadmium chloride and the distribution of metallothionein and cadmium along the villus-crypt axis in rat jejunum. Biol Trace Elem Res 42 (1994) 179-190
26. Felley-Bosco E., and Diezi J. Dietary calcium restriction enhances cadmium-induced metallothionein synthesis in rats. Toxicol Lett 60 (1992) 139-144
27. Friberg L., Elinder C.G., Kjellström T., and Nordberg G.F. Cadmium and health. A toxicological and epidemiological appraisal vol. II (1986), CRC Press, Inc., Boca Raton, Florida, USA 303 pp.
28. Ganong W.F. Review of medical physiology. 22nd edn. (2005), Appleton and Lange, USA 928 pp.
29. Gerson R.J., and Shaikh Z.A. Uptake and binding of cadmium and mercury to etallothionein in rat hepatocyte primary cultures. Biochem J 208 (1982) 465-472
30. Grandjean P., and Landrigan P.J. Review: Developmental neurotoxicity of industrial chemicals. Lancet 16 (2006) 2167-2178
31. Heinrich P.C., Castell J.V., and Audus T. Interleukin-6 and the acute phase response. Biochem J 265 (1990) 621-636
32. Iwata H., Masukawa T., Kitto H., and Hayashi M. Involvement of tissue sulfhydryls in the formation of a complex of methyl mercury with selenium. Biochem Pharmacol 30 (1981) 3159-3163
33. Johansen P., Kapel F.O., and Kraul I. Heavy metals and organochlorines in marine mammals from Greenland (1980), International Council for the Exploration of the Sea ICES C.M. 1980/E:32, 15 pp.
34. Joiris C.R., Holsbeek L., Bouquegneau J.M., and Bossicart M. Mercury contamination of the harbour porpoise (Phocoena phocoena) and other cetaceans from the North Sea and the Kattegat. Water Air Soil Pollut 56 (1991) 283-293
35. Julshamn K., and Brenna J. Determination of mercury in seafood by flow injection-cold vapor atomic absorption spectrometry after microwave digestion: NMKL interlaboratory study. Food Chem Cont 85 (2002) 626-631
36. Klaassen C.D., Amdur M.O., and Doull J. Casarett and Doulls toxicology. The basic science of poisons. 6th edn. (2007), McGraw-Hill, New York 1280 pp.
37. Klaassen C.D., Liu J., and Diwan B.A. Metallothionein protection of cadmium toxicity. Toxicol Appl Pharmacol 238 (2009) 215-220 Review
38. Koeman J.H., Peeters W.H.M., and Koudstaal-Hol C.H.M. Mercury-selenium correlations in marine mammals. Nature 245 (1973) 385-386
39. Kumari M.V., Hiramatsu M., and Ebadi M. Free radical scavenging actions of metallothionein isoforms I and II. Free Radic Res 29 (1998) 93-101
40. Law R.J. Cadmium in small mammals. Chapter 15. In: Beyer W.N., Heinz G.H., and Redmon-Norwood A.W. (Eds). Environmental contaminants in wildlife. Interpreting tissue concentrations. SETAC Special Publications Series (1996), CRC Press, New York 357-376
41. Lorentzen M., Maage A., and Julsham K. Supplementing copper to a fish meal based diet fed to Atlantic salmon parr affects liver copper and selenium concentrations. Aquacult Nutr 4 (1998) 67-72
42. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the folin phenol reagent. J Biol Chem 193 (1951) 265-275
43. Maage A., Julshamn K., and Andersen K.-J. Determination of selenium in acid digested marine samples by electrothermal atomic-absorption spectrometry with continuum source background correction and nickel as a chemical modifier. J Anal At Spectrom 6 (1991) 277-281
44. Maxie M.G. The urinary system. In: Jubb K.V.F., Kennedy P.C., and Palmer N. (Eds). Pathology of domestic animals. 4th vol. II (1993), Academic Press, San Diego 747 pp.
45. Muir D.C.G., Braune B., DeMarch B., Norstrom R., Wagemann R., Lockhart L., et al. Spatial and temporal trends and effects of contaminants in the Canadian Arctic marine ecosystem: a review. Sci Total Environ 230 (1999) 83-144
46. Muir D.C.G., Kwan M., and Lampe J. Spatial trends and pathways of POPs and metals in fish, shellfish and marine mammals of northern Labrador and Nunavik. In: Kalhok S. (Ed). Synopsis of research conducted under the 1998-1999 Northern Contaminants Program (1999), Department of Indian Affairs and Northern Development, Ottawa, Canada 165-171
47. Nielson K.B., Atkin C.L., and Winge D.R. Distinct metal-binding configurations in metallothionein. J Biol Chem 260 (1985) 5342-5350
48. Ohta H., and Cherian M.G. The influence of nutritional deficiencies on gastrointestinal uptake of cadmium and cadmium-metallothionein in rats. Toxicology 97 (1995) 71-80
49. Olsson P.E., and Olafson R.W. Electrochemical detection of metallothionein. Methods Enzymol 205 part B (1994) 205-213
50. Quakenbush L., and Citta J.J. Trace element concentrations in bearded seals (Erignathus barbatus) near Red Dog Mine compared to other locations in Alaska. J Marine Biol Article ID 275040 (2009)
51. Rabenstein D.L., Guevremont R., and Evans C.A. Glutathione and its metal-complexes. In: Siegel H. (Ed). Metal ions in Biological systems (1985), Marcel Dekker, New York 104-141
52. Rawson A.J., Patton G.W., Hofmann S., Pietra G.G., and Johns L. Liver abnormalities associated with chronic mercury accumulation in stranded atlanctic bottlenose dolphins. Ecotoxicol Environ Saf 25 (1993) 41-47
53. Ronald K., Frank R.J., and Dougan J. Pollutants in harp seals (Phoca groenlandica) II. Heavy metals and selenium. Sci Total Environ 38 (1984) 153-166
54. Rooney J.P. The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxicology 234 (2007) 145-156
55. Rumbeiha W.K., Fitzgerald S.D., Braselton W.E., Roth R.A., Pestka J.J., and Kaneene J.B. Augmentation of mercury-induced nephrotoxicity by endotoxin in the mouse. Toxicology 151 (2000) 103-116
56. Sato M., Sasaki M., and Hojo H. Induction of metallothionein synthesis by oxidative stress and possible role in acute phase response. In: Suzuki K.T., Imura N., and Kimura M. (Eds). Metallothionein III (1993), Birkhäuser Verlag, Basel 125-140
57. Sergeant D.E., and Armstrong F.A. Mercury in seals from eastern Canada. J Fish Res Bd Can 30 (1973) 843-846
58. Sonne C., Dietz R., Leifsson P.S., Asmund G., Born E.W., and Kirkegaard M. Are liver and renal lesions in East Greenland polar bears (Ursus maritimus) associated with high mercury levels?. Environ Health 6 (2007) 11
59. Sonne-Hansen C., Dietz R., Leifsson P.S., Hyldstrup L., and Rigét F.F. Cadmium toxicity to ringed seals (Phoca hispida) - an epidemiological study of possible cadmium induced nephropathy and osteodystrophy in ringed seals (Phoca hispida) from Qaanaaq in Northwest Greenland. Sci Total Environ 295 (2002) 167-181
60. Steinebach O.M., and Wolterbeek H.T. Role of cytosolic copper, metallothioein and glutathione in copper toxicity in rat hepatoma tissue-culture cells. Toxicology 92 (1994) 75-90
61. Teigen S.W., Andersen R.A., Daae H.L., and Skaare J.U. Heavy metal content in liver and kidneys of grey seals (Halichoerus grypus) in various life stages correlated with metallothionein levels: some metal-binding characteristics of this protein. Environ Toxicol Chem 18 (1999) 2364-2369
62. Thompson D.R. Mercury in birds and terrestrial mammals. In: Beyer W.N., Heinz G.H., and Redmon-Norwood A.W. (Eds). Environmental contaminants in wildlife: Interpreting tissue concentrations (1996) 341-356 CRC Press
63. Tohyama C., Himeno S., Watanabe C., Suzuki T., and Morita M. The relationship of the increased level of metallothionein with heavy metal levels in the tissue of the harbor seal (Phoca vitulina). Ecotoxicol Environ Saf 12 (1986) 85-94
64. Uchida Y., Takio K., Titani K., Ihara Y., and Tomonaga M. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron 7 (1991) 337-347
65. Webb M. Role of metallothionein in cadmium metabolism. In: Foulkes E.C. (Ed). Cadmium (1986), Springer Verlag, Berlin 280-337
66. WHO. IPCS - Environmental Health Criteria 134: cadmium (1992), WHO, Geneva, Schweiz 1-209
67. Woshner V.M., O'Hara T.M., Eurell J.A., Wallig M.A., Bratton G.R., Suydam R.S., et al. Distribution of inorganic mercury in liver and kidney of beluga and bowhead whales through autometallographic development of light microscopic tissue sections. Toxicol Pathol 30 (2002) 209-215