Nephrotoxic actions of low-dose mercury in mice: Protection by zinc

Archives of Environmental Health

Volumn 57, Issue 2, 2002, Pages 98-102

  Afonne, Onyenmechi J ^a   Orisakwe, Orish E ^a   Obi, Ejeatuluchukwu ^a   Dioka, Chudi E ^b   Ndubuka, Gideon I ^c  

^a Department of Pharmacology ^*  (Nigeria)

^b NNAMDI AZIKIWE UNIVERSITY   (Nigeria)

^c ABIA STATE UNIVERSITY   (Nigeria)

Author keywords

Histopathological effect; Mercury; Metal intake; Mice; Nephrotoxic action; Organ weight; Zinc

Indexed keywords

MERCURY; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOSE RESPONSE; GLOMERULUS; HISTOPATHOLOGY; KIDNEY DISEASE; KIDNEY MASS; KIDNEY NECROSIS; MERCURIALISM; MINERAL BALANCE; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING; ZINC METABOLISM;

ANIMALIA; GLOMERULUS;

EID: 0036523320     PISSN: 00039896     EISSN: None     Source Type: Journal    
DOI: 10.1080/00039890209602923     Document Type: Article

References (20)

1. Mueller PW, Price RG, Finn WF. New approaches for detecting threshold of human nephrotoxicity using cadmium as an example. Environ Health Perspect 1998; 106(5):227-230.
2. Pfaller W, Gstrauthaler G. Nephrotoxicity testing in vivo—what we know and what we need to know. Environ Health Perspect 1998; 106(Suppl 2):559-569.
3. Zalups RK, Cox C, Diamond Gl. Histological and urinalysis assessment of nephrotoxicity induced by mercuric chloride in normal and uninephrotomised rats. In: Clarkson TW, Friberg L, Nordberg GR, Sager PR (Eds). Biological Monitoring of Toxic Metals. New York: Plenum Press, 1988; pp 531-545.
4. Friberg L, Kjellstrom T, Nordberg GF. Cadmium, In Friberg L, Nordberg GF, Vouks V (Eds). Handbook on the Toxicology of Metal. Amsterdam, The Netherlands: Elsevier, 1986; pp 130-184.
5. Goering PL, Klaassen CD. Zinc-induced tolerance to cadmium hepatotoxicity. Toxicol Appl Pharmacol 1984; 74:299-307.
6. Khan AT, Graham TC, Webster JE, et al. Mercury levels in target organs of female rats following multiple doses of mercuric chloride. Fund Appl Toxicol 1996; 30(1):12.
7. Anderson MB, Lepak K, Farinas V, et al. Protective action of zinc against cobalt-induced testicular damage in the mouse. Reprod Toxicol 1993; 7:49-54.
8. Afonne OJ, Orisakwe OE, Ndubuka Gl, et al. Zinc protection of mercury-induced hepatic toxicity in mice. Biol Pharmacent Bull 2000; 23(3):305-308.
9. Pounds GJ. The toxic effects of metals. In: Williams PL, Burson JL (Eds). Industrial Toxicology New York: Van Nostrand Reinhold Co., 1985; pp 197-210.
10. Andersen O, Nielsen JB, Sorensen JA, et al. Experimental localisation of intestinal uptake site for metals (Cd, Hg, Zn, Se) in vitro in mice. Environ Health Perspect 1994; 102(Suppl 3):199-206.
11. Elsehans B, Schumann K, Forth W. Toxic metals: interactions with essential metals. In: Rowland Rl (Ed). Nutrition, Toxicity and Cancer. Boca Raton, FL: CRC Press, Inc., 1991; pp 223-258.
12. Kluwe WM. Renal function tests as indicators of kidney injury in subacute toxicity studies. Toxicol Appl Pharmacol 1981; 57:414-424.
13. Simmons JE, Yang RSH, Berman E. Evaluation of the nephrotoxicity of complex mixtures containing organs and metals: advantages and disadvantages of the use of real-world complex mixtures. Environ Health Perspect 1995; 103(Suppl 1):67-71.
14. Miller WJ. Zinc in animal and human health. In: Rose J (Ed). Trace Elements in Health. London, UK: Butherworths, 1983; pp 182-192.
15. Cousins RJ. Absorption, transport and Hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol Rev 1985; 65:238-309.
16. Kagi JHR, Schaffer A. Biochemistry of metallothionein. Biochem 1988; 27:8509-8575.
17. Harmer DH. Metallothionein. Ann Rev Biochem 1986; 55: 913-51.
18. Templeton DM, Cherian MG. Toxicological significance of metallothionein. In: Riordan JF, Vallee BF (Eds). Methods in Enzy-mology. Metallobiochemistry Part B: Metallothionein and Related Molecules, vol 205. San Diego, CA: Academic Press, 1991; pp 11-21.
19. Bogden JD, Kemp FW, Troiano RA, et al. Effect of mercuric chloride and methylmercury chloride exposure on tissue concentrations of six essential minerals. Environ Res 1980; 21:350-359.
20. Boscolo P, Carmignani M, Sacehettoni-Logroscino G, et al. Cardiovascular and renal effects of mercury exposure in rats. In: Astruc M, Lester Jn (Eds). Heavy Metals in the Hydrological Cycle. London, UK: Selper Ltd., 1988; pp 1-10.