Pregnancy-associated plasma protein A: Has this biomarker crossed the boundary from research to clinical practice?

Drug News and Perspectives

Volumn 22, Issue 6, 2009, Pages 341-348

  Consuegra Sanchez, Luciano ^a   Fredericks, Salim ^b   Kaski, Juan Carlos ^b  

^a Hospital Universitario Santa Maria del Rosell   (Spain)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CREATINE KINASE MB; MAJOR BASIC PROTEIN; PREGNANCY ASSOCIATED PLASMA PROTEIN A; TROPONIN;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL INJURY; CARDIOVASCULAR RISK; CLINICAL PRACTICE; CLINICAL RESEARCH; CLINICAL TRIAL; CORONARY ARTERY DISEASE; DIFFERENTIAL DIAGNOSIS; DOSE RESPONSE; DRUG DOSE COMPARISON; HISTOPATHOLOGY; HUMAN; HYPERCHOLESTEROLEMIA; KINETICS; PATHOGENESIS; PREECLAMPSIA; PROGNOSIS; PROTEIN DETERMINATION; REVIEW; STABLE ANGINA PECTORIS;

ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; FEMALE; HUMANS; MALE; MYOCARDIAL INFARCTION; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PROGNOSIS; RISK;

EID: 70350521382     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2009.22.6.1395257     Document Type: Review

References (51)

1. Fuster, V., Moreno, P.R., Fayad, Z.A. et al. Atherothrombosis and high-risk plaque: part I: evolving concepts. J Am Coll Cardiol 2005, 46(6): 937-954 (Pubitemid 41316498)
2. Chester, M.R., Chen, L., Tousoulis, D. et al. Differential progression of complex and smooth stenoses within the same coronary tree in men with stable coronary artery disease. J Am Coll Cardiol 1995, 25(4): 837-842
3. Harrington, S.C., Simari, R.D. and Conover, C.A. Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Circ Res 2007, 100(12): 1696-1702
4. Bayes-Genis, A., Conover, C.A., Overgaard, M.T. et al. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med 2001, 345(14): 1022-1029 (Pubitemid 34940794)
5. Cosin-Sales, J., Kaski, J.C., Christiansen, M. et al. Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris. Eur Heart J 2005, 26(20): 2093-2098
6. Cosin-Sales, J., Christiansen, M., Kaminski, P. et al. Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complex stenosis morphology in patients with stable angina pectoris. Circulation 2004, 109(14): 1724-1728
7. Lund, J., Qin, Q.P., Ilva, T. et al. Circulating pregnancy-associated plasma protein predicts outcome in patients with acute coronary syndrome but no troponin I elevation. Circulation 2003, 108(16): 1924-1926 (Pubitemid 37296534)
8. Heeschen, C., Dimmeler, S., Hamm, C.W. et al. Investigators CS. Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol 2005, 45(2): 229-237 (Pubitemid 40094730)
9. Qin, Q.P., Laitinen, P., Majamaa-Voltti, K. et al. Release patterns of pregnancy associated plasma protein A (PAPP-A) in patients with acute coronary syndromes. Scand Cardiovasc J 2002, 36(6): 358-361
10. Conover, C.A., Harrington, S.C., Bale, L.K. et al. Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages. Am J Physiol Heart Circ Physiol 2007, 292(2): H994-H1000.
11. Conover, C.A., Harrington, S.C. and Bale, L.K. Differential regulation of pregnancy associated plasma protein-A in human coronary artery endothelial cells and smooth muscle cells. Growth Horm IGF Res 2008, 18(3): 213-220
12. Conti, E., Carrozza, C., Capoluongo, E. et al. Insulin-like growth factor-1 as a vascular protective factor. Circulation 2004, 110(15): 2260-2265 (Pubitemid 39372511)
13. Conti, E., Volpe, M., Carrozza, C. et al. Pregnancy-associated plasma protein-A and acute coronary syndromes: cause or consequence? J Am Coll Cardiol 2005, 46(8): 1583-4.
14. Bersinger, N.A., Groome, N. and Muttukrishna, S. Pregnancy-associated and placental proteins in the placental tissue of normal pregnant women and patients with pre-eclampsia at term. Eur J Endocrinol 2002, 147(6): 785-793 (Pubitemid 36032968)
15. Laursen, L.S., Overgaard, M.T., Soe, R. et al. Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A. FEBS Lett 2001, 504(1-2): 36-40. (Pubitemid 32777807)
16. Lawrence, J.B., Oxvig, C., Overgaard, M.T. et al. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc Natl Acad Sci U S A 1999, 96(6): 3149-3153
17. Renier, G., Clement, I., Desfaits, A.C. et al. Direct stimulatory effect of insulin-like growth factor-I on monocyte and macrophage tumor necrosis factor-alpha production. Endocrinology 1996, 137(11): 4611-4618 (Pubitemid 26403296)
18. Bayes-Genis, A., Conover, C.A. and Schwartz, R.S. The insulin-like growth factor axis: a review of atherosclerosis and restenosis. Circ Res 2000, 86(2): 125-130 (Pubitemid 30086171)
19. Conti, E., Andreotti, F. and Zuppi, C. Pregnancy-associated plasma protein A as predictor of outcome in patients with suspected acute coronary syndromes. Circulation 2004, 109(18): e211-2.
20. Khosravi, J., Diamandi, A., Krishna, R.G. et al. Pregnancy associated plasma protein-A: ultrasensitive immunoassay and determination in coronary heart disease. Clin Biochem 2002, 35(7): 531-538 (Pubitemid 35462128)
21. Mikkelsen, J.H., Gyrup, C., Kristensen, P. et al. Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding. J Biol Chem 2008, 283(24): 16772-16780
22. Sangiorgi, G., Mauriello, A., Bonanno, E. et al. Pregnancy-associated plasma protein-A is markedly expressed by monocyte-macrophage cells in vulnerable and ruptured carotid atherosclerotic plaques: a link between inflammation and cerebrovascular events. J Am Coll Cardiol 2006, 47(11): 2201-2211 (Pubitemid 43795064)
23. Bayes-Genis, A., Schwartz, R.S., Lewis, D.A. et al. Insulin-like growth factor binding protein-4 protease produced by smooth muscle cells increases in the coronary artery after angioplasty. Arterioscler Thromb Vasc Biol 2001, 21(3): 335-341 (Pubitemid 32199113)
24. Mueller, T., Dieplinger, B., Poelz, W. et al. Increased pregnancy-associated plasma protein-A as a marker for peripheral atherosclerosis: Results from the Linz Peripheral Arterial Disease Study. Clin Chem 2006, 52(6): 1096-103. (Pubitemid 43794422)
25. Stulc, T., Malbohan, I., Malik, J. et al. Increased levels of pregnancy-associated plasma protein-A in patients with hypercholesterolemia: The effect of atorvastatin treatment. Am Heart J 2003, 146(6): E21.
26. Miedema, M.D., Conover, C.A., MacDonald, H. et al. Pregnancy-associated plasma protein-A elevation in patients with acute coronary syndrome and subsequent atorvastatin therapy. Am J Cardiol 2008, 101(1): 35-39 (Pubitemid 350297195)
27. Consuegra-Sanchez, L., Petrovic, I., Cosin-Sales, J. et al. Prognostic value of circulating pregnancy-associated plasma protein - A (PAPP-A) and proform of eosinophil major basic protein (pro-MBP) levels in patients with chronic stable angina pectoris. Clin Chim Acta 2008, 391(1-2): 18-23.
28. Elesber, A.A., Conover, C.A., Denktas, A.E. et al. Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina. Eur Heart J 2006, 27(14): 1678-1684
29. McCann, C.J., Glover, B.M., Menown, I.B. et al. Prognostic value of a multimarker approach for patients presenting to hospital with acute chest pain. Am J Cardiol 2009, 103(1): 22-28
30. Lund, J., Qin, Q.P., Ilva, T. et al. Pregnancy-associated plasma protein A: A biomarker in acute ST-elevation myocardial infarction (STEMI). Ann Med 2006, 38(3): 221-228 (Pubitemid 43675587)
31. Brügger-Andersen, T., Aarsetøy, H., Grundt, H. et al. The long-term prognostic value of multiple biomarkers following a myocardial infarction. Thromb Res 2008, 123(1): 60-66
32. Iversen, K.K., Teisner, A.S., Teisner, B. et al. Pregnancy-associated plasma protein A in non-cardiac conditions. Clin Biochem 2008, 41(7-8): 548-553
33. Elesber, A.A., Lerman, A., Denktas, A.E. et al. Pregnancy associated plasma protein-A and risk stratification of patients presenting with chest pain in the emergency department. Int J Cardiol 2007, 117(3): 365-369 (Pubitemid 46507629)
34. Laterza, O.F., Cameron, S.J., Chappell, D. et al. Evaluation of pregnancy-associated plasma protein A as a prognostic indicator in acute coronary syndrome patients. Clin Chim Acta 2004, 348(1-2): 163-169
35. Domínguez-Rodríguez, A., Abreu-González, P., García-González, M. et al. Circulating pregnancy-associated plasma protein A is not an early marker of acute myocardial infarction. Clin Biochem 2005, 38(2): 180-182 (Pubitemid 40092462)
36. Iversen, K.K., Teisner, A.S., Teisner, B. et al. Pregnancy associated plasma protein A, a novel, quick, and sensitive marker in ST-elevation myocardial infarction. Am J Cardiol 2008, 101(10): 1389-1394
37. McCann, C.J., Glover, B.M., Menown, I.B. et al. Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T. Eur Heart J 2008, 29(23): 2843-50.
38. Schoos, M., Iversen, K., Teisner, A. et al. Release patterns of pregnancy-associated plasma protein A in patients with acute coronary syndromes assessed by an optimized monoclonal antibody assay. Scand J Clin Lab Invest 2009, 69(1): 121-127
39. Iversen, K.K., Teisner, A.S., Teisner, B. et al. Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome. Clin Biochem 2009, 42(9): 828-834
40. Apple, F.S., Wu, A.H., Mair, J. et al. Committee on Standardization of Markers of Cardiac Damage of the IFCC. Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. Clin Chem 2005, 51(5): 810-824
41. Jaffe, A.S. and Katus, H. Acute coronary syndrome biomarkers: The need for more adequate reporting. Circulation 2004, 110(2): 104-106 (Pubitemid 38924574)
42. Packard, R.R. and Libby, P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem 2008, 54(1): 24-38. (Pubitemid 351182593)
43. Qin, Q.P., Kokkala, S., Lund, J. et al. Molecular distinction of circulating pregnancy-associated plasma protein A in myocardial infarction and pregnancy. Clin Chem 2005, 51(1): 75-83. (Pubitemid 40028321)
44. Qin, Q.P., Kokkala, S., Lund, J. et al. Immunoassays developed for pregnancy-associated plasma protein-A (PAPP-A) in pregnancy may not recognize PAPP-A in acute coronary syndromes. Clin Chem 2006, 52(3): 398-404. (Pubitemid 43306462)
45. Fredericks, S., Bertomeu-Gonzalez, V., Petrovic, I. et al. Comment on immunoassays developed for pregnancy-associated plasma protein-A (PAPP-A) in pregnancy may not recognize PAPP-A in acute coronary syndromes. Clin Chem 2006, 52(8): 1619-1620 (Pubitemid 44148338)
46. Lauzurica, R., Pastor, C., Bayés, B. et al. Pretransplant pregnancy-associated plasma protein-a as a predictor of chronic allograft nephropathy and posttransplant cardiovascular events. Transplantation 2005, 80(10): 1441-1446 (Pubitemid 41803627)
47. Terkelsen, C.J., Oxvig, C., Nørgaard, B.L. et al. Temporal course of pregnancy-associated plasma protein-A in angioplasty-treated ST-elevation myocardial infarction patients and potential significance of concomitant heparin administration. Am J Cardiol 2009, 103(1): 29-35.
48. Gyrup, C., Christiansen, M. and Oxvig, C. Quantification of proteolytically active pregnancy-associated plasma protein-A with an assay based on quenched fluorescence. Clin Chem 2007, 53(3): 947-954 (Pubitemid 46744253)
49. Hughes, G., Bischof, P., Wilson, G. et al. Assay of a placental protein to determine fetal risk. Br Med J 1980, 280(6215): 671-673 (Pubitemid 10184294)
50. Carty, D.M., Delles, C. and Dominiczak, A.F. Novel biomarkers for predicting preeclampsia. Trends Cardiovasc Med 2008, 18(5): 186-194
51. Hlatky, M.A., Greenland, P., Arnett, D.K. et al. Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association. Circulation 2009, 119: e606.