Release patterns of pregnancy-associated plasma protein a in patients with acute coronary syndromes assessed by an optimized monoclonal antibody assay

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 69, Issue 1, 2009, Pages 121-127

  Schoos, Mikkel ^a,b   Iversen, Kasper ^a   Teisner, Ane ^c   Teisner, Børge ^d   Thaning, Pia ^b   Kliem, Anette ^e   Grande, Peer ^a   Clemmensen, Peter ^a  

^a University of Copenhagen   (Denmark)

^b AMAGER HOSPITAL   (Denmark)

^c HVIDOVRE HOSPITAL   (Denmark)

^d London Bridge Fertility   (United Kingdom)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Angioplasty transluminaly percutaneous intervention; Atherosclerosis; Cardiovascular disease; Coronary thrombosis; Myocardial ischaemia

Indexed keywords

MONOCLONAL ANTIBODY; PREGNANCY ASSOCIATED PLASMA PROTEIN A;

ACUTE CORONARY SYNDROME; ADULT; AGED; BLOOD SAMPLING; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART INFARCTION; HIGH RISK POPULATION; HUMAN; IMMUNOASSAY; MALE; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; RISK ASSESSMENT; RISK FACTOR; ST ELEVATION MYOCARDIAL INFARCTION; ST SEGMENT ELEVATION; SYMPTOM; UNSTABLE ANGINA PECTORIS;

ACUTE CORONARY SYNDROME; AGED; ANTIBODIES, MONOCLONAL; FEMALE; HUMANS; IMMUNOASSAY; MALE; MIDDLE AGED; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A;

ANGINA;

EID: 61649096175     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510802439080     Document Type: Conference Paper

References (16)

1. Bassand JP, Hamm CW, Ardissino D, Boersma E, Budaj A, Fernandez-Aviles F, Fox KA, Hasdai D, Ohman EM, Wallentin L, Wijns W. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J 2007;28:1598-660.
2. Schwartz RS, Bayes-Genis A, Lesser JR, Sangiorgi M, Henry TD, Conover CA. Detecting vulnerable plaque using peripheral blood: inflammatory and cellular markers. J Interv Cardiol 2003;16:231-42.
3. Bayes-Genis A, Conover CA, Overgaard MT, Bailey KR, Christiansen M, Holmes DR Jr., Virmani R, Oxvig C, Schwartz RS. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med 2001;345:1022-9.
4. Bayes-Genis A, Schwartz RS, Lewis DA, Overgaard MT, Christiansen M, Oxvig C, Ashai K, Holmes DR, Jr., Conover CA. Insulin-like growth factor binding protein-4 protease produced by smooth muscle cells increases in the coronary artery after angioplasty. Arterioscler Thromb Vasc Biol 2001;21:335-41.
5. Lund J, Qin QP, Ilva T, Pettersson K, Voipio-Pulkki LM, Porela P, Pulkki K. Circulating pregnancy-associated plasma protein A predicts outcome in patients with acute coronary syndrome but no troponin I elevation. Circulation 2003;108:1924-6.
6. Cosin-Sales J, Christiansen M, Kaminski P, Oxvig C, Overgaard MT, Cole D, Holt DW, Kaski JC. Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complex stenosis morphology in patients with stable angina pectoris. Circulation 2004;109:1724-8.
7. Heeschen C, Dimmeler S, Hamm CW, Fichtlscherer S, Simoons ML, Zeiher AM. Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol 2005;45:229-37.
8. Rossen M, Iversen K, Teisner A, Teisner B, Kliem A, Grudzinskas G. Optimisation of sandwich ELISA based on monoclonal antibodies for the specific measurement of pregnancy-associated plasma protein (PAPP-A) in acute coronary syndrome. Clin Biochem 2007;40:478-84.
9. Westergaard J. Studies on pregnancy associated plasma protein A (PAPP-A) in normal and abnormal pregnancy. [Thesis/Dissertion].
10. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002;105:1135-43.
11. Laursen LS, Overgaard MT, Nielsen CG, Boldt HB, Hopmann KH, Conover CA, Sottrup-Jensen L, Giudice LC, Oxvig C. Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis. Biochem J 2002;367:31-40.
12. Conover CA, Harrington SC, Bale LK, Oxvig C. Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages. Am J Physiol Heart Circ Physiol 2007;292:994-1000.
13. Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation 2005;111:3481-8.
14. Lund J, Qin QP, Ilva T, Nikus K, EskolaM, Porela P, Kokkala S, Pulkki K, Pettersson K, Voipio-Pulkki LM. Pregnancy-associated plasma protein A: a biomarker in acute ST-elevation myocardial infarction (STEMI). Ann Med 2006;38:221-8.
15. Brugger-Andersen T, Hetland O, Ponitz V, Grundt H, Nilsen DW. The effect of primary percutaneous coronary intervention as compared to tenecteplase on myeloperoxidase, pregnancy-associated plasma protein A, soluble fibrin andD-dimer in acute myocardial infarction. Thromb Res 2007;119:415-21.
16. Andersen DC, Koch C, Jensen CH, Skjodt K, Brandt J, Teisner B. High prevalence of human anti-bovine IgG antibodies as the major cause of false positive reactions in two-site immunoassays based on monoclonal antibodies. J Immunoassay Immunochem 2004;25:17-30.