LH/hCGR gene expression in human cumulus cells is linked to the expression of the extracellular matrix modifying gene TNFAIP6 and to serum estradiol levels on day of hCG administration

Human Reproduction

Volumn 24, Issue 11, 2009, Pages 2868-2878

  Haouzi, D ^a,b,c   Assou, S ^a,b,c   Mahmoud, K ^d   Hedon, B ^b   De Vos, J ^a,c   Dewailly, D ^e   Hamamah, S ^a,b,c  

^a UNIV MONTPELLIER   (France)

^b HÔPITAL ARNAUD DE VILLENEUVE   (France)

^c INSERM   (France)

^d Centre de FIV   (Tunisia)

^e LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

Cumulus cells; LH hCGR; TNFAIP6 gene

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN RECEPTOR; ESTRADIOL; GONALF; HUMAN MENOPAUSAL GONADOTROPIN; LUTEINIZING HORMONE; MESSENGER RNA; RECOMBINANT FOLLITROPIN; RECOMBINANT LUTEINIZING HORMONE; TRANSCRIPTOME; TUMOR NECROSIS FACTOR ALPHA; TUMOUR NECROSIS FACTOR ALPHA INDUCED PROTEIN 6; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CUMULUS CELL; DNA MICROARRAY; ESTRADIOL BLOOD LEVEL; FEMALE; GENE EXPRESSION; GRANULOSA CELL; HUMAN; HUMAN CELL; INTRACYTOPLASMIC SPERM INJECTION; MALE; OOCYTE; OVARY HYPERSTIMULATION; OVULATION; STEROID METABOLISM;

EID: 70350517965     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dep263     Document Type: Article

References (37)

1. Assou S, Anahory T, Pantesco V, Le Carrour T, Pellestor F, Klein B, Reyftmann L, Dechaud H, De Vos J, Hamamah S. The human cumulus-oocyte complex gene expression profile. Hum Reprod 2006; 21:1705-1719.
2. Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet 2001; 29:365-371.
3. Calder MD, Caveney AN, Smith LC, Watson AJ. Responsiveness of bovine cumulus-oocyte-complexes (COC) to porcine and recombinant human FSH, and the effect of COC quality on gonadotropin receptor and Cx43 marker gene mRNAs during maturation in vitro. Reprod Biol Endocrinol 2003;11:1-14.
4. Calder MD, Caveney AN, Sirard MA, Watson AJ. Effect of serum and cumulus cell expansion on marker gene transcripts in bovine cumulus-oocyte complexes during maturation in vitro. Fertil Steril 2005;83(Suppl 1):1077-1085.
5. Chen L, Russell PT, Larsen WJ. Sequential effects of follicle-stimulating hormone and luteinizing hormone on mouse cumulus expansion in vitro. Biol Reprod 1994;51:290-295.
6. Cheng ZN, Shu Y, Liu ZQ, Wang LS, Ou-Yang DS, Zhou HH. Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin 2001;22:148-154.
7. Chian RC, Ao A, Clarke HJ, Tulandi T, Tan SL. Production of steroids from human cumulus cells treated with different concentrations of gonadotropins during culture in vitro. Fertil Steril 1999;71:61-66.
8. Diaz FJ, O'Brien MJ, Wigglesworth K, Eppig JJ. The preantral granulosa cell to cumulus cell transition in the mouse ovary: development of competence to undergo expansion. Dev Biol 2006;299:91-104.
9. Diaz FJ, Wigglesworth K, Eppig JJ. Oocytes are required for the preantral granulosa cell to cumulus cell transition in mice. Dev Biol 2007; 305:300-311.
10. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genomewide expression patterns. Proc Natl Acad Sci USA 1998; 95:14863-14868.
11. Eppig JJ, Chesnel F, Hirao Y, O'Brien MJ, Pendola FL, Watanabe S, Wigglesworth K. Oocyte control of granulosa cell development: how and why. Hum Reprod 1997;12(Suppl 11):127-132.
12. Erickson GF, Shimasaki S. The role of the oocyte in folliculogenesis. Trends Endocrinol Metab 2000;11:193-198.
13. Fu M, Chen X, Yan J, Lei L, Jin S, Yang J, Song X, Zhang M, Xia G. Luteinizing hormone receptors expression in cumulus cells closely related to mouse oocyte meiotic maturation. Front Biosci 2007; 12:1804-1813.
14. Fulop C, Szanto S, Mukhopadhyay D, Bardos T, Kamath RV, Rugg MS, Day AJ, Salustri A, Hascall VC, Glant TT et al. Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice. Development 2003;130:2253-2261.
15. Grøndahl ML, Borup R, Lee YB, Myrhøj V, Meinertz H, Sørensen S. Differences in gene expression of granulosa cells from women undergoing controlled ovarian hyperstimulation with either recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropin. Fertil Steril 2009;91:1820-1830.
16. Hayes C, Spink D, Spink B, Cao J, Walker N, Sutter T. 17ß-Estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc Natl Acad Sci USA 1996;93:9776-9781.
17. Kash JC, Menon KM. Identification of a hormonally regulated luteinizing hormone/human chorionic gonadotropin receptor mRNA binding protein. Increased mRNA binding during receptor down-regulation. J Biol Chem 1998;273:10658-10664.
18. Kawashima I, Okazaki T, Noma N, Nishibori M, Yamashita Y, Shimada M. Sequential exposure of porcine cumulus cells to FSH and/or LH is critical for appropriate expression of steroidogenic and ovulation-related genes that impact oocyte maturation in vivo and in vitro. Reproduction 2008;136:9-21.
19. Kolena J, Kiss A, Channing CP. Purification of porcine granulosa cells by continuous Percoll gradient. Experientia 1983;39:908-909.
20. Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT. Characterization of the oxidative metabolites of 17ß-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology 2003;144:3382-3398.
21. Lee TH, Liu CH, Huang CC, Wu YL, Shih YT, Ho HN, Yang YS, Lee MS. Serum anti-Müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles. Hum Reprod 2008;23:160-167.
22. Luo W, Wiltbank MC. Distinct regulation by steroids of messenger RNAs for FSHR and CYP19A1 in bovine granulosa cells. Biol Reprod 2006; 75:217-225.
23. Mingoti GZ, Garcia JM, Rosa-e-Silva AAM. Steroidogenesis in cumulus cells of bovine cumulus-oocyte complexes matured in vitro with BSA and different concentrations of steroids. Anim Reprod Sci 2002; 69:175-186.
24. Müller T, Gromoll J, Simoni M. Absence of exon 10 of the human luteinizing hormone (LH) receptor impairs LH, but not human chorionic gonadotropin action. J Clin Endocrinol Metab 2003; 88:2242-2249.
25. Nakamura K, Yamashita S, Omori Y, Minegishi T. A splice variant of the human luteinizing hormone (LH) receptor modulates the expression of wild-type human LH receptor. Mol Endocrinol 2004;18:1461-1470.
26. Ochsner SA, Day AJ, Rugg MS, Breyer RM, Gomer RH, Richards JS. Disrupted function of tumor necrosis factor-alpha-stimulated gene 6 blocks cumulus cell-oocyte complex expansion. Endocrinology 2003; 144:4376-4384.
27. Peegel H, Randolph J Jr, Midgley AR, Menon KM. In situ hybridization of luteinizing hormone/human chorionic gonadotropin receptor messenger ribonucleic acid during hormone-induced down-regulation and the subsequent recovery in rat corpus luteum. Endocrinology 1994;135:1044-1051.
28. Peng XR, Hsueh AJ, LaPolt PS, Bjersing L, Ny T. Localization of luteinizing hormone receptor messenger ribonucleic acid expression in ovarian cell types during follicle development and ovulation. Endocrinology 1991; 129:3200-3207.
29. Penning TM, Jin Y, Steckelbroeck S, Lanisnik Rizner T, Lewis M. Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins. Mol Cell Endocrinol 2004;215:63-72.
30. Platteau P, Smitz J, Albano C, Sørensen P, Arce JC, Devroey P. Exogenous luteinizing hormone activity may influence the treatment outcome in in vitro fertilization but not in intracytoplasmic sperm injection cycles. Fertil Steril 2004;81:1401-1404.
31. Sayasith K, Doré M, Sirois J. Molecular characterization of tumor necrosis alpha-induced protein 6 and its human chorionic gonadotropin-dependent induction in theca and mural granulose cells of equine preovulatory follicles. Reproduction 2007;133:135-145.
32. Shi H, Segaloff DL. A role for increased lutropin/choriogonadotropin receptor (LHR) gene transcription in the follitropin-stimulated induction of the LHR in granulosa cells. Mol Endocrinol 1995;9:734-744.
33. Shimada M, Hernandez-Gonzalez I, Gonzalez-Robanya I, Richards JS. Induced expression of pattern recognition receptors in cumulus oocyte complexes: novel evidence for innate immune-like functions during ovulation. Mol Endocrinol 2006;20:3228-3239.
34. Shirazi A, Moalemian Z. Ovine cumulus cells estradiol-17Beta production in the presence or absence of oocyte. Anim Reprod Sci 2007; 101:125-133.
35. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001;98:5116-5121.
36. Yang SH, Son WY, Yoon SH, Ko Y, Lim JH. Correlation between in vitro maturation and expression of LH receptor in cumulus cells of the oocytes collected from PCOS patients in HCG-primed IVM cycles. Hum Reprod 2005;20:2097-2103.
37. Yoshioka S, Ochsner S, Russell DL, Ujioka T, Fujii S, Richards JS, Espey LL. Expression of tumor necrosis factor-stimulated gene-6 in the rat ovary in response to an ovulatory dose of gonadotropin. Endocrinology 2000; 141:4114-4119. (Pubitemid 30953524)