Predictive control of hollow-fiber bioreactors for the production of monoclonal antibodies

Biotechnology and Bioengineering

Volumn 63, Issue 4, 1999, Pages 484-492

  Dowd, Jason E ^a   Weber, Ingrid ^a,b,c   Rodriguez, Beatriz ^c   Piret, James M ^a   Kwok, K Ezra ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b INSA   (France)

^c StemCell Technologies Inc   (Canada)

Author keywords

Hollow fiber bioreactors; Monoclonal antibodies; Perfusion; Predictive control

Indexed keywords

BIOREACTORS; CELL CULTURE; COMPUTER CONTROL SYSTEMS; COMPUTER SOFTWARE; GLUCOSE; GRAPHICAL USER INTERFACES; PREDICTIVE CONTROL SYSTEMS; PROCESS CONTROL;

HOLLOW-FIBER BIOREACTORS;

MONOCLONAL ANTIBODIES;

GLUCOSE; LACTIC ACID; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; BIOREACTOR; COMPUTER SYSTEM; GLUCOSE TRANSPORT; HOLLOW FIBER MEMBRANE; HYBRIDOMA; MOUSE; NONHUMAN; RAT;

ALGORITHMS; ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL LINE; CULTURE MEDIA; EQUIPMENT DESIGN; HYBRIDOMAS; IMMUNOGLOBULIN G; KINETICS; MICE; RATS;

ANIMALIA;

EID: 0033586944     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19990520)63:4<484::AID-BIT12>3.0.CO;2-5     Document Type: Article

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