Protection against hypercholesterolemia by corni fructus extract and its related protective mechanism

Journal of Medicinal Food

Volumn 12, Issue 5, 2009, Pages 973-981

  Park, Chan Hum ^a   Cho, Eun Ju ^b   Yokozawa, Takako ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b Pusan National University   (South Korea)

Author keywords

Cholesterol; Corni Fructus; Hypercholesterolemia; Oxidative stress; Peroxisome proliferator activated receptor x

Indexed keywords

BILE ACID; CHOLESTEROL; CHOLIC ACID; CORNI FRUCTUS EXTRACT; LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PLANT EXTRACT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; BODY WEIGHT; CARDIOVASCULAR DISEASE; CATABOLISM; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORNI FRUCTUS; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DRUG MECHANISM; FATTY ACID OXIDATION; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; LIPID PEROXIDATION; LIPOPROTEIN BLOOD LEVEL; MALE; MEDICINAL PLANT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYSTOLIC BLOOD PRESSURE; UPREGULATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; BILE ACIDS AND SALTS; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CHOLESTEROL; CORNUS; DIET, ATHEROGENIC; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUIT; HYPERCHOLESTEROLEMIA; LIPID PEROXIDATION; LIVER; MALE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PPAR ALPHA; PROTECTIVE AGENTS; RATS; RATS, WISTAR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

RATTUS;

EID: 70350512585     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2009.0037     Document Type: Article

References (40)

1. Krieger M: The "best" of cholesterols, the "worst" of cholesterols: a tale of two receptors. Proc Natl Acad Sci U S A 1998;95: 4077-4080.
2. Brown WV: What are the priorities for managing cholesterol effectively? Am J Cardiol 2001;88(Suppl):21F-24F.
3. Kwiterovich PO Jr: The effect of dietary fat, antioxidants and pro-oxidants on blood lipids and lipoproteins and atherosclerosis. J Am Diet Assoc 1997;97(Suppl):S31-S41.
4. Levine GN, Keaney JF, Vita JA: Cholesterol reduction in cardiovascular disease: clinical benefits and possible mechanisms. N Engl J Med 1995;332:512-521.
5. Arafa HM: Curcumin attenuates diet-induced hypercholesterolemia in rats. Med Sci Monit 2005;11:BR228-BR234.
6. Yokozawa T, Ishida A, Cho EJ, Nakagawa T: The effects of Coptidis Rhizoma extract on a hypercholesterolemic animal model. Phytomedicine 2003;10:17-22.
7. Yokozawa T, Nakagawa T, Kitani K: Antioxidative activity of green tea polyphenol in cholesterol-fed rats. J Agric Food Chem 2002;50:3549-3552.
8. Chang JS, Chiang LC, Hsu FF, Lin CC: Chemoprevention against hepatocellular carcinoma of Cornus officinalis in vitro. Am J Clin Med 2004;32:717-725.
9. Liou SS, Liu IM, Hsu SF, Cheng JT: Corni fructus as the major herb of Die-Huang-Wan for lowering plasma glucose in Wistar rats. J Pharm Pharmacol 2004;56:1443-1447.
10. Yokozawa T, Yamabe N, Kim HY, Kang KS, Hur JM, Park CH, Tanaka T: Protective effects of morroniside isolated from Corni Fructus against renal damage in streptozotocin-induced diabetic rats. Biol Pharm Bull 2008;31:1422-1428.
11. Yamabe N, Kang KS, Matsuo Y, Tanaka T, Yokozawa T: Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimi-jio-gan, in streptozotocin-induced diabetic rats. Biol Pharm Bull 2007;30:1289-1296.
12. Kim HY, Yokozawa T, Kim HY, Tohda C, Rao TP, Juneja LR: Influence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats. J Nutr Sci Vitaminol 2005;51:413-418.
13. Yamabe N, Kang KS, Goto E, Tanaka T, Yokozawa T: Beneficial effect of Corni Fructus, a constituent of Hachimijio- gan, on advanced glycation end-product-mediated renal injury in streptozotocin-treated diabetic rats. Biol Pharm Bull 2007;30: 520-526.
14. Havel RD, Eder HA, Bragdon JH: The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955;34:1345-1353.
15. Noma A, Nezu-Nakayama K, Kita M, Okabe H: Simultaneous determination of serum cholesterol in high- and low-density lipoproteins with use of heparin, Ca2+, and an anion-exchange resin. Clin Chem 1978;24:1504-1508.
16. Naito C, Yamanaka T: Lipid peroxides in atherosclerotic diseases. Jpn J Geriatr 1978;15:187-191.
17. Folch J, Lees M, Sloane Stanley GH: A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509.
18. Iwami K, Fujii N, Suzuka T, Kanamoto R: A crucial role of soybean resistant protein in increased fecal steroid excretion and structural peculiarity of caught bile acids. Soy Protein Res 2002; 5:58-62.
19. Tani Y, Mizuno S, Sumioka M, Umeshita K, Isozuma M: A comparison of lipid metabolism improvement by feeding soybean or natto to rats fed with high-fed diet. Nagoya Women's University Annals 2005;51:59-67.
20. Rangan GK, Wang Y, Tay YC, Harris DC: Inhibition of nuclear factor-kB activation reduces cortical tubulo-interstitial injury in proteinuric rats. Kidney Int 1999;56:118-134.
21. Vareed SK, Reddy MK, Schutzki RE, Nair MG: Anthocyanins in Cornus alternifolia, Cornus controversa, Cornus kousa and Cornus florida fruits with health benefits. Life Sci 2006;78:777-784.
22. Wang SF, Chen XG, Hu ZD, Ju Y: Analysis of three effective components in Fructus corni and its preparations by micellar electrokinetic capillary chromatography. Biomed Chromatogr 2003;17:306-311.
23. Xu HQ, Hao HP, Zhang X, Pan Y: Morroniside protects cultured human umbilical vein endothelial cells from damage by high ambient glucose. Acta Pharmacol Sin 2004;25:412-415.
24. Ogawa H, Nioshikawa T, Sasagawa S: Effect of cholesterol feeding on the compositions of plasma lipoproteins and plasma lipolytic activities in SHRSP. Clin Exp Hypertens A 1991;13:999-1008.
25. Ross R: The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993;362:801-809.
26. Schaefer EJ, Lichtenstein AH, Lamon-Fava S, McNamara JR, Ordovas JM: Lipoproteins, nutrition, aging, and atherosclerosis. Am J Clin Nutr 1995;61(3 Suppl):726S-740S.
27. Assmann G, Gotto AM Jr: HDL cholesterol and protective factors in atherosclerosis. Circulation 2004;109(23 Suppl I):III8-III14.
28. Assmann G, Nofer JR: Atheroprotective effects of high-density lipoproteins. Annu Rev Med 2003;54:321-341.
29. Gordon DJ, Rifkind BM: High-density lipoprotein: the clinical implications of recent studies. N Engl J Med 1989;321:1311-1316.
30. Wannamethee SG, Shaper AG, Ebrahim S: HDL-cholesterol, total cholesterol, and the risk of stroke in middle-aged British men. Stroke 2000;31:1882-1888.
31. Ros E: Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk. Atherosclerosis 2000;151:357-379.
32. Kim EJ, Lee HI, Chung KJ, Noh YH, Ro Y, Koo JH: The ginsenoside-Rb2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions. BMB Rep 2009;42:194-199.
33. Kris-Etherton PM, Pearson TA, Wan Y, Hargrove RL, Moriarty K, Fishell V, Etherton TD: High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations. Am J Clin Nutr 1999;70:1009-1015.
34. Prasad K, Kalra J: Experimental atherosclerosis and oxygen free radicals. Angiology 1989;40:835-843.
35. Bonomini F, Tengattini S, Fabiano A, Bianchi R, Rezzani R: Atherosclerosis and oxidative stress. Histol Histopathol 2008;23: 381-390.
36. Hsiai T, Berliner JA: Oxidative stress as a regulator of murine atherosclerosis. Curr Drug Targets 2007;8:1222-1229.
37. Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N: Absence of sterol regulatory elementbinding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lepob=Lepob mice. J Biol Chem 2002;277:19353-19357.
38. Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, Gotoda T, Ishibashi S, Yamada N: Sterol regulatory element-binding protein- 1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J Biol Chem 1999;274:35832-35839.
39. Evans JL, Goldfine ID, Maddux BA, Grodsky GM: Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002;23:599-622.
40. Ferré P: The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 2004;53(Suppl 1):S43-S50.