Oxycodone-related fatalities in the West of Scotland

Journal of Analytical Toxicology

Volumn 33, Issue 8, 2009, Pages 423-432

  Al Asmari, Ahmed I ^a   Anderson, Robert A ^a   Cooper, Gail A A ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; MORPHINE DERIVATIVE; NOROXYCODONE; OXYCODONE; OXYMORPHONE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG FATALITY; DRUG INTOXICATION; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; LIQUID CHROMATOGRAPHY; UNITED KINGDOM;

EID: 70350508886     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/33.8.423     Document Type: Conference Paper

References (48)

1. E. Kalso. Oxycodone. J. Pain Symptom Manage. 29(5 Suppl): S47-56 (2005).
2. R.C. Baselt. Disposition of Toxic Drugs and Chemicals in Man, 7th ed. Biomedical Publications, Foster City, CA, 2004.
3. E.J. Cone, R.V. Fant, J.M. Rohay, Y.H. Caplan, M. Ballina, R.F. Reder, D. Spyker, and J.D. Haddox. Oxycodone involvement in drug abuse deaths: a DAWN-based classification scheme applied to an oxycodone postmortem database containing over 1000 cases. J. Anal. Toxicol. 27: 57-67 (2003).
4. D.D. Baker and A.J. Jenkins. A comparison of methadone, oxycodone, and hydrocodone related deaths in northeast Ohio. J. Anal. Toxicol. 32: 165-171 (2008).
5. D.T. Anderson, K.L. Fritz, and J.J. Muto. Oxycontin® : the concept of a "ghost pill" and the postmortem tissue distribution of oxycodone in 36 cases. J. Anal. Toxicol. 26: 448-459 (2002).
6. B. Lalovic, E. Kharasch, C. Hoffer, L. Risler, L.Y. Liu-Chen, and D.D. Shen. Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clin. Pharmacol. Ther. 79: 461-479 (2006).
7. B. Lalovic, B. Phillips, L.L. Risler, W. Howald, and D.D. Shen. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab. Dispos. 32: 447-454 (2004).
8. J.K. Coller, L.L. Christrup, and A.A. Somogyi. Role of active metabolites in the use of opioids. Eur. J. Clin. Pharmacol. 65: 121-139 (2009).
9. K.A. Moore, V. Ramcharitar, B. Levine, and D. Fowler. Tentative identification of novel oxycodone metabolites in human urine. J. Anal. Toxicol. 27: 346-352 (2003).
10. S. McKinley, J.J. Snyder, E. Welsh, C.M. Kazarian, M.H. Jamerson, and K.L. Klette. Rapid quantification of urinary oxycodone and oxymorphone using fast gas chromatography-mass spectrometry. J. Anal. Toxicol. 31: 434-441 (2007).
11. M.L. Smith, R.O. Hughes, B. Levine, S. Dickerson, W.D. Darwin, and E.J. Cone. Forensic drug testing for opiates. VI. Urine testing for hydromorphone, hydrocodone, oxymorphone, and oxycodone with commercial opiate immunoassays and gas chromatography-mass spectrometry. J. Anal. Toxicol. 19: 18-26 (1995).
12. J.D. Ropero-Miller, M.K. Lambing, and R.E. Winecker. Simultaneous quantitation of opioids in blood by GC-EI-MS analysis following deproteination, detautomerization of keto analytes, solidphase extraction, and trimethylsilyl derivatization. J. Anal. Toxicol. 26: 524-528 (2002).
13. P. Wang, J.A. Stone, K.H. Chen, S.F. Gross, C.A. Haller, and A.H. Wu. Incomplete recovery of prescription opioids in urine using enzymatic hydrolysis of glucuronide metabolites. J. Anal. Toxicol. 30: 570-575 (2006).
14. W. Nowatzke, J. Zeng, A. Saunders, A. Bohrer, J. Koenig, and J. Turk. Distinction among eight opiate drugs in urine by gas chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 20: 815-828 (1999).
15. R.C. Backer, J.R. Monforte, and A. Poklis. Evaluation of the DRI oxycodone immunoassay for the detection of oxycodone in urine. J. Anal. Toxicol. 29: 675-677 (2005).
16. R. Meatherall. GC-MS confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine. J. Anal. Toxicol. 23: 177-186 (1999).
17. L.A. Broussard, L.C. Presley, T. Pittman, R. Clouette, and G.H. Wimbish. Simultaneous identification and quantitation of codeine, morphine, hydrocodone, and hydromorphone in urine as trimethylsilyl and oxime derivatives by gas chromatography-mass spectrometry. Clin. Chem. 43: 1029-1032 (1997).
18. O.H. Drummer, M.L. Syrjanen, M. Phelan, and S.M. Cordner. A study of deaths involving oxycodone. J. Forensic Sci. 39: 1069-1075 (1994).
19. M.T. Smith, J.A. Watt, G.P. Mapp, and T. Cramond. Quantitation of oxycodone in human plasma using high-performance liquid chromatography with electrochemical detection. Ther. Drug. Monit. 13: 126-130 (1991).
20. A. Wright, J.A. Lawrence, M. Lu, T. Cramond, and M.T. Smith. Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma. J. Chromatogr. B 712: 169-175 (1998).
21. A. Menelaou, M.R. Hutchinson, I. Quinn, A. Christensen, and A.A. Somogyi. Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 785: 81-88 (2003).
22. O. Cheremina, I. Bachmakov, A. Neubert, K. Brune, M.F. Fromm, and B. Hinz. Simultaneous determination of oxycodone and its major metabolite, noroxycodone, in human plasma by high-performance liquid chromatography. Biomed. Chromatogr. 19: 777-782 (2005).
23. M. Dawson, B. Fryirs, T. Kelly, J. Keegan, and L.E. Mather. A rapid and sensitive high-performance liquid chromatography-electrospray ionization-triple quadrupole mass spectrometry method for the quantitation of oxycodone in human plasma. J. Chromatogr. Sci. 40: 40-44 (2002).
24. M. Neuvonen and P.J. Neuvonen. Determination of oxycodone, noroxycodone, oxymorphone, and noroxymorphone in human plasma by liquid chromatography- electrospray-tandem mass spectrometry. Ther. Drug. Monit. 30: 333-340 (2008).
25. S.R. Edwards and M.T. Smith. Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 814: 241-249 (2005).
26. L.E. Edinboro, R.C. Backer, and A. Poklis. Direct analysis of opiates in urine by liquid chromatography-tandem mass spectrometry. J. Anal. Toxicol. 29: 704-710 (2005).
27. R. Coles, M.M. Kushnir, G.J. Nelson, G.A. McMillin, and F.M. Urry. Simultaneous determination of codeine, morphine, hydrocodone, hydromorphone, oxycodone, and 6-acetylmorphine in urine, serum, plasma, whole blood, and meconium by LC-MS-MS. J. Anal. Toxicol. 31: 1-14 (2007).
28. S.R. Edwards and M.T. Smith. Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high-performance liquid chromatography-electrospray ionization-tandem. J. Chromatogr. B 848: 264-270 (2007).
29. B.C. Wolf, W.A. Lavezzi, L.M. Sullivan, and L.M. Flannagan. One hundred seventy two deaths involving the use of oxycodone in Palm Beach County. J. Forensic Sci. 50: 192-195 (2005).
30. D.N. Sims and J. Gardner. Oxycodone poisoning. Bull. Int. Assoc. Forensic Toxicol. 24: 27-29 (1994).
31. L.J. Langman and E. Pfeifer. Deaths attributed to intravenous use and nasal inhalation of oxycodone. Proceedings of American Academy of Forensic Sciences Annual Meeting, Washington, D.C., 2008, p 432.
32. J.M. Winterling, R.T. Callery, and M.J. Caplan. Oxycodone-related deaths in Delaware. Proceedings of American Academy of Forensic Sciences Annual Meeting, Chicago, IL, 2003, pp 307-308.
33. R.C. Backer and A. Poklis. Oxycodone blood concentrations in seventy postmortem cases [K19]. Proceedings of American Academy of Forensic Sciences Annual Meeting, New Orleans, LA, 2005, pp 364-365.
34. J.G. Thompson, S. Vanderwerf, J. Seningen, M. Carr, J. Kloss, and F.S. Apple. Free oxycodone concentrations in 67 postmortem cases from the Hennepin County medical examiner's office. J. Anal. Toxicol. 32: 673-679 (2008).
35. E.J. Cone, R.V. Fant, J.M. Rohay, Y.H. Caplan, M. Ballina, R.F. Reder, and J.D. Haddox. Oxycodone involvement in drug abuse deaths. II. Evidence for toxic multiple drug-drug interactions. J. Anal. Toxicol. 28: 217-225 (2004).
36. B. Levine, K.A. Moore, P. Aronica-Pollak, and D.F. Fowler. Oxycodone intoxication in an infant: accidental or intentional exposure?. J. Forensic Sci. 49: 1358-1360 (2004).
37. E.J. Armstrong, A.J. Jenkins, G.F. Sebrosky, and E.K. Balraj. An unusual fatality in a child due to oxycodone. Am. J. Forensic Med. Pathol. 25: 338-341 (2004).
38. H.A. Spiller. Postmortem oxycodone and hydrocodone blood concentrations. J. Forensic Sci. 48: 429-431 (2003).
39. A.I. Al-Asmari and R.A. Anderson. Method for quantification of opioids and their metabolites in autopsy blood by liquid chromatography-tandem mass spectrometry. J. Anal. Toxicol. 31: 394-408 (2007).
40. B.K. Matuszewski, M.L. Constanzer, and C.M. Chavez-Eng. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 75: 3019-3030 (2003).
41. SOFT/AAFS. Forensic toxicology laboratory guidelines. 2006 version. http://www.soft-tox.org/docs/Guidelines%202006%202020 Final.pdf.
42. H. Kokki, I. Rasanen, M. Lasalmi, S. Lehtola, V.P. Ranta, K. Vanamo, and I. Ojanpera. Comparison of oxycodone pharmacokinetics after buccal and sublingual administration in children. Clin. Pharmacokinet. 45: 745-754 (2006).
43. A. Liukas, K. Kuusniemi, R. Aantaa, P. Virolainen, M. Neuvonen, P. Neuvonen, and K. Olkkola. Plasma concentrations of oral oxycodone are greatly increased in the elderly. Clin. Pharmacol. Ther. 84: 462-467 (2008).
44. L.S. Goodman, A. Gilman, J. Hardman, L.E. Limbird, and R. Rall. Goodman and Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill, New York, NY, 1996.
45. R. Hargrove, D. Garside, and R. Winecker. Oxymorphone concentrations in post-mortem blood. Proceedings of Society of Forensic Toxicologists Annual Meeting, Phoenix, AZ, 2008, p S18.
46. G.S. Behonick, T. Valouch, A. Sexton, C. Roberts, and J. Kuhlman. Two fatal case reports of oxymorphone occurring in Massachusetts and Virginia. Proceedings of Society of Forensic Toxicologists Annual Meeting, Phoenix, AZ, 2008, p S21.
47. D. Garside, R.L. Hargrove, and R.E. Winecker. Concentration of oxymorphone in postmortem fluids and tissue. J. Anal. Toxicol. 33: 121-128 (2009).
48. J.W. Mandema, R.F. Kaiko, B. Oshlack, R.F. Reder, and D.R. Stanski. Characterization and validation of a pharmacokinetic model for controlled-release oxycodone. Br. J. Clin. Pharmacol. 42: 747-756 (1996).