Simultaneous identification and quantitation of codeine, morphine, hydrocodone, and hydromorphone in urine as trimethylsilyl and oxime derivatives by gas chromatography-mass spectrometry

Clinical Chemistry

Volumn 43, Issue 6, 1997, Pages 1029-1032

  Broussard, Larry A ^a   Presley, Lance C ^b   Pittman, Thomas ^c   Clouette, Randy ^d   Wimbish, Gary H ^d  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b LABORATORY CORPORATION OF AMERICA   (United States)

^c TF Puckett Laboratory   (United States)

^d Harrison Laboratories   (United States)

Author keywords

Abused drugs; Drug monitoring; Forensic toxicology; Opiates

Indexed keywords

CODEINE; HYDROCODONE; HYDROMORPHONE; MORPHINE; NORCODEINE; OXIME DERIVATIVE; OXYCODONE; OXYMORPHONE; TRIMETHYLSILYL DERIVATIVE;

ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG ABUSE; DRUG MONITORING; DRUG SCREENING; GAS CHROMATOGRAPHY; HYDROLYSIS; ION MONITORING; MASS SPECTROMETRY; SOLID PHASE EXTRACTION; URINALYSIS;

EID: 0030974673     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/43.6.1029     Document Type: Article

References (10)

1. Cone EJ, Dickerson S, Paul BD, Mitchell JM. Forensic drug testing for opiates, IV. Analytical sensitivity, specificity, and accuracy of commercial urine opiate immunoassays. J Anal Toxicol 1992;16: 72-8.
2. Goldberger BA, Cone EJ. Confirmatory tests for drugs in the workplace by gas chromatography-mass spectrometry [Review]. J Chromatogr 1994;674:73-86.
3. Wasels R, Belleville F. Gas chromatographic-mass spectrometric procedures used for the identification and determination of morphine, codeine and 6-monoacetylmorphine [Review]. J Chromatogr 1994;674:225-34.
4. Chen BH, Taylor EH, Pappas AA. Comparison of derivatives for determination of codeine and morphine by gas chromatography/ mass spectrometry. J Anal Toxicol 1990;14:12-7.
5. Grinstead GF. A closer look at acetyl and pentafluoropropionyl derivatives for quantitative analysis of morphine and codeine by gas chromatography/mass spectrometry. J Anal Toxicol 1991;15: 293-8.
6. Fenton J, Mummert J, Childers M. Hydromorphone and hydrocodone interference in GC/MS assays for morphine and codeine. J Anal Toxicol 1994;18:159-64.
7. Solans A, DeLaTorre R, Segura J. Determination of morphine and codeine in urine by gas chromatography-mass spectrometry. J Pharm Biomed Anal 1990;8:905-9.
8. Kushmir M, Jones C, Struempler R, Urry FM. Eliminating interferences of related compounds in opiates GC/MS analysis [Abstract]. Clin Chem 1996;42:S218.
9. Clouette R, Wimbish GH. Improved chromatographic separation of opiates as TMS derivatives by formation of the oxime-TMS derivatives of hydrocodone and hydromorphone [Abstract]. J Anal Toxicol 1996;20:77.
10. Jones CW, Chaney G, Mastorides S. Simultaneous analysis of opiates in urine by SPE and GC-MS with stabilization of ketoopiates via conversion to oxime derivative [Abstract]. J Anal Toxicol 1997;21:86.