Microarray-based gene expression analysis as a process characterization tool to establish comparability of complex biological products: Scale-up of a whole-cell immunotherapy product

Biotechnology and Bioengineering

Volumn 104, Issue 4, 2009, Pages 796-808

  Wang, Min ^a,e   Senger, Ryan S ^b,c,f   Paredes, Carlos ^c,g   Banik, Gautam G ^d   Lin, Andy ^d   Papoutsakis, Eleftherios T ^a,b,c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b University of Delaware   (United States)

^c Northwestern University   (United States)

^d CELL GENESYS INC   (United States)

^e ABBOTT LABORATORIES   (United States)

^f Virginia Polytechnic Institute and State University   (United States)

^g NONE   (United States)

Author keywords

Cancer immunotherapy; Cell culture; Cellular vaccine; Genome scale analysis; Microarrays; Process characterization; Quality control; Scale up; Statistical analysis

Indexed keywords

CANCER IMMUNOTHERAPY; CELLULAR VACCINE; GENOME SCALE ANALYSIS; PROCESS CHARACTERIZATION; SCALE UP; STATISTICAL ANALYSIS;

ANIMAL CELL CULTURE; ASSAYS; BIOACTIVITY; CELL CULTURE; CELL MEMBRANES; EVOLUTIONARY ALGORITHMS; GENES; KNOWLEDGE BASED SYSTEMS; MICROARRAYS; NUCLEIC ACIDS; PROCESS MONITORING; PRODUCT DEVELOPMENT; PRODUCTION ENGINEERING; PROJECT MANAGEMENT; QUALITY ASSURANCE; QUALITY FUNCTION DEPLOYMENT; STATISTICAL PROCESS CONTROL; STATISTICAL TESTS; STATISTICS; TOTAL QUALITY MANAGEMENT; TRANSCRIPTION;

QUALITY CONTROL;

BIOLOGICAL PRODUCT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ARTICLE; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CELL THERAPY; DNA MICROARRAY; GENE EXPRESSION; GENETIC ENGINEERING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOTHERAPY; PROSTATE CANCER; RNA EXTRACTION; SCALE UP; WHOLE CELL;

CELL CULTURE TECHNIQUES; CELLS, CULTURED; GENE EXPRESSION PROFILING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; QUALITY CONTROL; TECHNOLOGY, PHARMACEUTICAL;

BOVINAE;

EID: 70350508291     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22441     Document Type: Article

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