Selective enrichment of hepatocellular cancer stem cells by chemotherapy

Journal of International Medical Research

Volumn 37, Issue 4, 2009, Pages 1046-1056

  Tan, S ^a   Chen, J S ^a   Sun, L J ^a   Yao, He Rui ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cancer stem cells; Chemotherapy; Hepatocellular carcinoma

Indexed keywords

CYCLOPHOSPHAMIDE; ALKYLATING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CANCER STEM CELL; CARCINOGENICITY; CELL PROLIFERATION; CELL RENEWAL; CHROMOSOME ANALYSIS; COLONY FORMATION; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; TUMOR VOLUME; ANIMAL; BAGG ALBINO MOUSE; CELL SEPARATION; CULTURE TECHNIQUE; DRUG EFFECT; DRUG SCREENING; GENETICS; LIVER TUMOR; METHODOLOGY; MULTICELLULAR SPHEROID; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CARCINOMA, HEPATOCELLULAR; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; CYCLOPHOSPHAMIDE; CYTOGENETIC ANALYSIS; FLOW CYTOMETRY; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASTIC STEM CELLS; SPHEROIDS, CELLULAR; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 70350504860     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000903700409     Document Type: Article

References (20)

1. Okuda K: Hepatocellular carcinoma. J Hepatol 2000; 32(suppl): 225-237.
2. Reya T, Morrison SJ, Clarke MF, et al: Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105-111.
3. Al-Hajj M, Clarke MF: Self-renewal and solid tumor stem cells. Oncogene 2004; 23: 7274-7282. (Pubitemid 39382161)
4. Lapidot T, Sirard C, Vormoor J, et al: A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994; 367: 645-648. (Pubitemid 24067706)
5. Bonnet D, Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730-737. (Pubitemid 27298715)
6. Al-Hajj M, Wicha MS, Benito-Hernandez A, et al: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003; 100: 3983-3988. (Pubitemid 36418143)
7. Singh SK, Hawkins C, Clarke ID, et al: Identification of human brain tumour initiating cells. Nature 2004; 432: 396-401. (Pubitemid 39551674)
8. + hepatocellular carcinoma cells as cancer stem/progenitor cells. Biochem Biophys Res Commun 2006; 351: 820-824.
9. Yin S, Li J, Hu C, et al: CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int J Cancer 2007; 120: 1444-1450. (Pubitemid 46355378)
10. - glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res 2007; 67: 4010-4015.
11. Dong RC, Zhou RH, Lu FD, et al: Establishment of a human hepatocarcinoma cell line SMMC-7721 and the initial observations on its biologic characteristics. Acad J Sec Mil Med Univ 1980; 1: 5-9.
12. Dontu G, Abdallah WM, Foley JM, et al: In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003; 17: 1253-1270. (Pubitemid 36583168)
13. Zhu S, Si ML, Wu H, et al: MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 2007; 282: 14328-14336. (Pubitemid 47100416)
14. - cancer cells are similarly tumorigenic. Cancer Res 2005; 65: 6207-6219.
15. Clarke MF, Dick JE, Dirks PB, et al: Cancer stem cells-perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res 2006; 66: 9339-9344.
16. Hamburger AW, Salmon SE: Primary bioassay of human tumor stem cells. Science 1977; 197: 461-463.
17. Yu F, Yao H, Zhu P, et al: let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007; 131: 1109-1123. (Pubitemid 350235025)
18. Chiba T, Kita K, Zheng YW, et al: Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 2006; 44: 240-251. (Pubitemid 44049156)
19. + HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 2008; 27: 1749-1758.
20. Bao S, Wu Q, McLendon RE, et al: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444: 756-760. (Pubitemid 44949604)