A simple approach for the synthesis of new classes of dithiocarbamate-linked peptidomimetics

Tetrahedron Letters

Volumn 50, Issue 50, 2009, Pages 7062-7066

  Hemantha, Hosahalli P ^a   Sureshbabu, Vommina V ^a  

^a Dr B R Ambedkar Veedhi   (India)

Author keywords

Carbon disulfide; Dithiocarbamate; Dithiocarbamic acid; Peptidomimetics

Indexed keywords

AMINO ACID DERIVATIVE; AMINO ALKYL IODIDE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CARBON DISULFIDE; CHLORIDE; DITHIOCARBAMIC ACID DERIVATIVE; ESTER DERIVATIVE; FLUORENYLMETHYLOXYCARBONYL CHLORIDE; HALIDE; IODINE DERIVATIVE; PEPTIDOMIMETIC AGENT; TRIETHYLAMINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; DRUG SYNTHESIS; MITSUNOBU REACTION;

EID: 70350496713     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.09.172     Document Type: Article

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45. 2-I] (4 mmol) in THF was added slowly and the reaction mixture was allowed to warm to rt gradually and stirred for two hours. After completion of the reaction (TLC), it was evaporated under vacuum and the crude was partitioned between ethyl acetate (15 mL) and water. The organic layer was washed with citric acid solution (10%, 10 mL), water and brine. After drying over sodium sulfate, the organic phase was concentrated and the crude was purified through column chromatography using EtOAc in hexane (10-15%) as eluent.
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47. -1.
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