Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle

Journal of Cellular Biochemistry

Volumn 108, Issue 4, 2009, Pages 963-973

  O'Neal, Patrick ^a   Alamdari, Nima ^a   Smith, Ira ^a   Poylin, Vitaliy ^a   Menconi, Michael ^a   Hasselgren, Per Olof ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Muscle atrophy; Muscle wasting; Proteasome; Protein breakdown; Protein degradation; Thyroid hormone; Thyrotoxicosis; Ubiquitin

Indexed keywords

ATROGIN 1; CALPAIN; CASPASE 3; CATHEPSIN L; LIOTHYRONINE; MESSENGER RNA; MUSCLE PROTEIN; MUSCLE RING FINGER 1 PROTEIN; THYROTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; GENE EXPRESSION; HORMONE BLOOD LEVEL; HYPERTHYROIDISM; MALE; MUSCLE ATROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SKELETAL MUSCLE; UPREGULATION;

ANIMALS; CASPASE 3; CATHEPSIN L; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPERTHYROIDISM; LYSOSOMES; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCLES; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; SKP CULLIN F-BOX PROTEIN LIGASES; THYROTROPIN; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

RATTUS;

EID: 70350490071     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22329     Document Type: Article

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