Whole body and forearm substrate metabolism in hyperthyroidism: Evidence of increased basal muscle protein breakdown

American Journal of Physiology - Endocrinology and Metabolism

Volumn 288, Issue 6 51-6, 2005, Pages

  Riis, Anne Lene Dalkjær ^a   Jørgensen, Jens Otto Lunde ^a   Gjedde, Signe ^a   Nørrelund, Helene ^a   Jurik, Anne Grethe ^a   Nair, K S ^b   Ivarsen, Per ^c   Weeke, Jørgen ^a   Møller, Niels ^c  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c MAYO CLINIC   (United States)

Author keywords

Amino acids; Energy metabolism; Hyperthyroidism; Protein breakdown; Protein synthesis; Skeletal muscle; Stable isotopes; Tracers

Indexed keywords

AMINO ACID; LIOTHYRONINE; MUSCLE PROTEIN; PHENYLALANINE; THIAMAZOLE; TRACER; TYROSINE;

ADULT; ARTICLE; BASAL METABOLIC RATE; CLINICAL ARTICLE; CONTROLLED STUDY; DILUTION; ENERGY METABOLISM; FEMALE; FOREARM; GRAVES DISEASE; HUMAN; HYPERTHYROIDISM; MOLECULAR DYNAMICS; MUSCLE ATROPHY; MUSCLE FUNCTION; MUSCLE MASS; MYOPATHY; NITROGEN NUCLEAR MAGNETIC RESONANCE; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS;

ADULT; ANTITHYROID AGENTS; BODY COMPOSITION; FEMALE; FOREARM; HUMANS; HYPERTHYROIDISM; KINETICS; METHIMAZOLE; MIDDLE AGED; MUSCLE PROTEINS; MUSCLE, SKELETAL; NITROGEN ISOTOPES; PHENYLALANINE; THYROID HORMONES;

EID: 19444364957     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00253.2004     Document Type: Article

References (43)

1. Adlerberth A, Angeras U, Jagenburg R, Lindstedt G, Stenstrom G, and Hasselgren PO. Urinary excretion of 3-methylhistidine and creatinine and plasma concentrations of amino acids in hyperthyroid patients following preoperative treatment with antithyroid drug or beta-blocking agent: results from a prospective, randomized study. Metabolism 36: 637-642, 1987.
2. Andersen L, Dinesen B, Jorgensen PN, Poulsen F, and Roder ME. Enzyme immunoassay for intact human insulin in serum or plasma. Clin Chem 39: 578-582, 1993.
3. Clausen T, Van-Hardeveld C, and Everts ME. Significance of cation transport in control of energy metabolism and thermogenesis. Physiol Rev 71: 733-774, 1991.
4. Copeland KC and Nair KS. Acute growth hormone effects on amino acid and lipid metabolism. J Clin Endocrinol Metab 78: 1040-1047, 1994.
5. Foss MC, Paccola GM, Saad MJ, Pimenta WP, Piccinato CE, and Iazigi N. Peripheral glucose metabolism in human hyperthyroidism. J Clin Endocrinol Metab 70: 1167-1172, 1990.
6. Gelfand RA, Hutchinson-Williams KA, Bonde AA, Castellino P, and Sherwin RS. Catabolic effects of thyroid hormone excess: the contribution of adrenergic activity to hypermetabolism and protein breakdown. Metabolism 36: 562-569, 1987.
7. Hagg SA and Adibi SA. Leucine metabolism in thyrotoxicosis: plasma aminogram and 3-methylhistidine excretion before and after treatment. Metabolism 34: 813-816, 1985.
8. Haymond MW and Miles JM. Branched chain amino acids as a major source of alanine nitrogen in man. Diabetes 31: 86-89, 1982.
9. Holecek M. Relation between glutamine, branched-chain amino acids, and protein metabolism. Nutrition 18: 130-133, 2002.
10. Iranmanesh A, Lizarralde G, Johnson ML, and Veldhuis JD. Nature of altered growth hormone secretion in hyperthyroidism. J Clin Endocrinol Metab 72: 108-115, 1991.
11. Jensen MD, Miles JM, Gerich JE, Cryer PE, and Haymond MW. Preservation of insulin effects on glucose production and proteolysis during fasting. Am J Physiol Endocrinol Metab 254: E700-E707, 1988.
12. Jones BN and Gilligan JP. o-Phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids. J Chromatogr 266: 471-482, 1983.
13. Liu Z and Barrett EJ. Human protein metabolism: its measurement and regulation. Am J Physiol Endocrinol Metab 283: E1105-E1112, 2002.
14. Lloyd B, Burrin J, Smythe P, and Alberti KG. Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin Chem 24: 1724-1729, 1978.
15. Louard RJ, Barrett EJ, and Gelfand RA. Overnight branched-chain amino acid infusion causes sustained suppression of muscle proteolysis. Metabolism 44: 424-429, 1995.
16. Martin WH, Spina RJ, Korte E, Yarasheski KE, Angelopoulos TJ, Nemeth PM, and Saffitz JE. Mechanisms of impaired exercise capacity in short duration experimental hyperthyroidism. J Clin Invest 88: 2047-2053, 1991.
17. Møller N, Butler PC, Antsiferov MA, and Alberti KG. Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man. Diabetologia 32: 105-110, 1989.
18. Møller N, Meek S, Bigelow M, Andrews J, and Nair KS. The kidney is an important site for in vivo phenylalanine-to-tyrosine conversion in adult humans: a metabolic role of the kidney. Proc Natl Acad Sci USA 97: 1242-1246, 2000.
19. Møller N, Nielsen S, Nyholm B, Pørksen N, Alberti KG, and Weeke J. Glucose turnover, fuel oxidation and forearm substrate exchange in patients with thyrotoxicosis before and after medical treatment. Clin Endocrinol (Oxf) 44: 453-459, 1996.
20. Morrison WL, Gibson JN, Jung RT, and Rennie MJ. Skeletal muscle and whole body protein turnover in thyroid disease. Eur J Clin Invest 18: 62-68, 1988.
21. Muller MJ and Seitz HJ. Thyroid hormone action on intermediary metabolism. Part I: respiration, thermogenesis and carbohydrate metabolism. Klin Wochenschr 62: 11-18, 1984.
22. Nair KS, Ford GC, Ekberg K, Fernqvist FE, and Wahren J. Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients. J Clin Invest 95: 2926-2937, 1995.
23. Nair KS, Welle SL, Halliday D, and Campbell RG. Effect of beta-hydroxybutyrate on whole-body leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans. J Clin Invest 82: 198-205, 1988.
24. Nørrelund H, Hove KY, Brems-Dalgaard E, Jurik AG, Nielsen LP, Nielsen S, Jørgensen JO, Weeke J, and Møller N. Muscle mass and function in thyrotoxic patients before and during medical treatment. Clin Endocrinol (Oxf) 51: 693-699, 1999.
25. Nørrelund H, Riis AL, and Møller N. Effects of GH on protein metabolism during dietary restriction in man. Growth Hormone IGF Res 12: 198-207, 2002.
26. Orskov H, Thomsen HG, and Yde H. Wick chromatography for rapid and reliable immunoassay of insulin, glucagon and growth hormone. Nature 219: 193-195, 1968.
27. Ramsay ID. Muscle dysfunction in hyperthyroidism. Lancet 2: 931-934, 1966.
28. Riis ALD, Gravholt CH, Djurhuus CB, Nørrelund H, Jørgensen JOL, Weeke J, and Møller N. Elevated regional lipolysis in hyperthyroidism. J Clin Endocrinol Metab 87: 4747-4753, 2002.
29. Rochon C, Tauveron I, Dejax C, Benoit P, Capitan P, Bayle G, Prugnaud J, Fabricio A, Berry C, Champredon C, Thieblot P, and Grizard J. Response of leucine metabolism to hyperinsulinemia in hypothyroid patients before and after thyroxine replacement. J Clin Endocrinol Metab 85: 697-706, 2000.
30. Rodier M, Richard JL, Bringer J, Cavalie G, Bellet H, and Mirouze J. Thyroid status and muscle protein breakdown as assessed by urinary 3-methylhistidine excretion: study in thyrotoxic patients before and after treatment. Metabolism 33: 97-100, 1984.
31. Sandler MP, Robinson RP, Rabin D, Lacy WW, and Abumrad NN. The effect of thyroid hormones on gluconeogenesis and forearm metabolism in man. J Clin Endocrinol Metab 56: 479-485, 1983.
32. Sestoft L. Metabolic aspects of the calorigenic effect of thyroid hormone in mammals. Clin Endocrinol (Oxf) 13: 489-506, 1980.
33. Shulman GI, Ladenson PW, Wolfe MH, Ridgway EC, and Wolfe RR. Substrate cycling between gluconeogenesis and glycolysis in euthyroid, hypothyroid, and hyperthyroid man. J Clin Invest 76: 757-764, 1985.
34. Snitker S, Tataranni PA, and Ravussin E. Spontaneous physical activity in a respiratory chamber is correlated to habitual physical activity. Int J Obes Relat Metab Disord 25: 1481-1486, 2001.
35. Tauveron I, Charrier S, Champredon C, Bonnet Y, Berry C, Bayle G, Prugnaud J, Obled C, Grizard J, and Thieblot P. Response of leucine metabolism to hyperinsulinemia under amino acid replacement in experimental hyperthyroidism. Am J Physiol Endocrinol Metab 269: E499-E507, 1995.
36. Tessari P, Nissen SL, Miles JM, and Haymond MW. Inverse relationship of leucine flux and oxidation to free fatty acid availability in vivo. J Clin Invest 77: 575-581, 1986.
37. 5]phenylalanine model. Am J Physiol Endocrinol Metab 256: E631-E639, 1989.
38. Wahren J, Wennlund A, Nilsson LH, and Felig P. Influence of hyperthyroidism on splanchnic exchange of glucose and gluconeogenic precursors. J Clin Invest 67: 1056-1063, 1981.
39. Weeke J, Boye N, and Ørskov H. Ultrafiltration method for direct radioimmunoassay measurement of free thyroxine and free tri-iodothyronine in serum. Scand J Clin Lab Invest 46: 381-389, 1986.
40. Weeke J and Ørskov H. Ultrasensitive radioimmunoassay for direct determination of free triiodothyronine concentration in serum. Scand J Clin Lab Invest 35: 237-244, 1975.
41. Wiles CM, Young A, Jones DA, and Edwards RH. Muscle relaxation rate, fibre-type composition and energy turnover in hyper- and hypothyroid patients. Clin Sci (Colch) 57: 375-384, 1979.
42. Yates RO, Connor H, and Woods HF. Muscle protein breakdown in thyrotoxicosis assessed by urinary 3-methylhistidine excretion. Ann Nutr Metab 25: 262-267, 1981.
43. Zanetti M, Barazzoni R, Kiwanuka E, and Tessari P. Effects of branched-chain-enriched amino acids and insulin on forearm leucine kinetics. Clin Sci (Lond) 97: 437-448, 1999.