Hypothermic responses to infection are inhibited by α2- adrenoceptor agonists with possible clinical implications

British Journal of Anaesthesia

Volumn 103, Issue 4, 2009, Pages 554-560

  Tolchard, S ^a,b   Burns, P A ^c,d   Nutt, D J ^b   Fitzjohn, S M ^b  

^a FRENCHAY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c BRISTOL ROYAL INFIRMARY   (United Kingdom)

^d Orchard Medical Centre   (United Kingdom)

Author keywords

Adrenergic receptors; Bacterial infection; Temperature

Indexed keywords

2 (2 ETHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; BACTERIUM LIPOPOLYSACCHARIDE; BRIMONIDINE; CORTICOSTERONE; MIVAZEROL; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; IMIDAZOLE DERIVATIVE; LIGAND; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DOSE COMPARISON; HYPOTHERMIA; INFECTION; INFUSION RATE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THERMOREGULATION; ANIMAL; BACTERIAL INFECTION; BLOOD; DISEASE MODEL; DRUG EFFECT; DRUG POTENTIATION; DRUG SCREENING; METHODOLOGY; MICROBIOLOGY; WISTAR RAT;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BACTERIAL INFECTIONS; BODY TEMPERATURE REGULATION; CORTICOSTERONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HYPOTHERMIA; IMIDAZOLES; LIGANDS; LIPOPOLYSACCHARIDES; MALE; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 70350459097     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aep199     Document Type: Article

References (43)

1. Ambrose C, Sale S, Howells R, et al. Intravenous clonidine infusion in critically ill children: dose-dependent sedative effects and cardiovascular stability. Br J Anaesth 2000; 84: 794-796
2. Jenkins I. The provision of analgesia and sedation in the PICU: current practice and recent advances. Paediatr Anaesth 2002; 12: 837-839
3. McSPI-Europe Research Group. Perioperative sympatholysis. Beneficial effects of the alpha 2-adrenoceptor agonist mivazerol on hemodynamic stability and myocardial ischemia. Anesthesiology 1997; 86: 346-363
4. Tobias JD. Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit. Crit Care Med 2000; 28: 2122-2132
5. Derijk RH, Van Kampen M, Van Rooijen N, Berkenbosch F. Hypothermia to endotoxin involves reduced thermogenesis, macrophage-dependent mechanisms, and prostaglandins. Am J Physiol 1994; 266: R1-8
6. Hare AS, Clarke G, Tolchard S. Bacterial lipopolysaccharideinduced changes in FOS protein expression in the rat brain: correlation with thermoregulatory changes and plasma corticosterone. J Neuroendocrinol 1995; 7: 791-799
7. Kluger MJ, Kozak W, Leon LR, Soszynski D, Conn CA. Fever and antipyresis. Prog Brain Res 1998; 115: 465-475
8. Tolchard S, Hare AS, Nutt DJ, Clarke G. TNF alpha mimics the endocrine but not the thermoregulatory responses of bacterial lipopolysaccharide (LPS): correlation with FOS-expression in the brain. Neuropharmacology 1996; 35: 243-248
9. Cartmell T, Luheshi GN, Rothwell NJ. Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat. J Physiol 1999; 518: 585-594
10. Cartmell T, Poole S, Turnbull AV, Rothwell NJ, Luheshi GN. Circulating interleukin-6 mediates the febrile response to localised inflammation in rats. J Physiol 2000; 526: 653-661
11. Jansky L, Vybiral S, Pospisilova D, et al. Production of systemic and hypothalamic cytokines during the early phase of endotoxin fever. Neuroendocrinology 1995; 62: 55-61
12. Jiang Q, Cross AS, Singh IS, Chen TT, Viscardi RM, Hasday JD. Febrile core temperature is essential for optimal host defense in bacterial peritonitis. Infect Immun 2000; 68: 1265-1270
13. Roth J. Immunological and neuroendocrine modulation of fever in stress. Prog Brain Res 1998; 115: 177-192
14. Harbuz MS, Rees RG, Eckland D, Jessop DS, Brewerton D, Lightman SL. Paradoxical responses of hypothalamic corticotropin-releasing factor (CRF) messenger ribonucleic acid (mRNA) and CRF-41 peptide and adenohypophysial proopiomelanocortin mRNA during chronic inflammatory stress. Endocrinology 1992; 130: 1394-1400
15. Noyer M, de Laveleye F, Vauquelin G, Gobert J, Wulfert E. Mivazerol, a novel compound with high specificity for alpha 2 adrenergic receptors: binding studies on different human and rat membrane preparations. Neurochem Int 1994; 24: 221-229
16. Dalley JW, Stanford SC. Contrasting effects of the imidazol(in)e alpha 2-adrenoceptor agonists, medetomidine, clonidine and UK 14,304 on extraneuronal levels of noradrenaline in the rat frontal cortex: evaluation using in vivo microdialysis and synaptosomal uptake studies. Br J Pharmacol 1995; 114: 1717-1723
17. Stillings MR, Chapleo CB, Butler RC, et al. Alpha-adrenoreceptor reagents. 3. Synthesis of some 2-substituted 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists. J Med Chem 1985; 28: 1054-1062
18. Jeon YT, Luo C, Forray C, Vaysse PJ-J, Branchek TA, Gluchowski C. Pharmacological evaluation of UK-14,304 analogs at cloned human adrenergic receptors. J Med Chem 1995; 5: 2255-2258
19. Pauwels PJ, Colpaert FC. Partial to complete antagonism by putative antagonists at the wild-type alpha(2C)-adrenoceptor based on kinetic analyses of agonist:antagonist interactions. Br J Pharmacol 2000; 131: 1385-1390
20. Dalley JW, Parker CA, Wulfert E, Hudson AL, Nutt DJ. Potentiation of barbiturate-induced alterations in presynaptic noradrenergic function in rat frontal cortex by imidazol(in)e alpha2-adrenoceptor agonists. Br J Pharmacol 1998; 125: 441-446
21. Szreder Z. Comparison between thermoregulatory effects mediated by alpha 1-and alpha 2-adrenoceptors in normothermic and febrile rabbits. Gen Pharmacol 1993; 24: 929-941
22. Bencsics A, Elenkov IJ, Vizi ES. alpha 2-, alpha 2A-, alpha 2B/2CAdrenoceptor subtype antagonists prevent lipopolysaccharideinduced fever response in rabbits. Brain Res 1995; 705: 302-306
23. Dilsaver SC, Davidson RK. Chronic treatment with amitriptyline produces subsensitivity to the hypothermic effects of yohimbine. Prog Neuropsychopharmacol Biol Psychiatry 1989; 13: 211-215
24. Czarnecka E, Tymczyszyn W. The influence of calcium channel blockers on the central action of clonidine. Pol J Pharmacol 1994; 46: 125-131
25. Myers RD, Beleslin DB, Rezvani AH. Hypothermia: role of alpha 1-and alpha 2-noradrenergic receptors in the hypothalamus of the cat. Pharmacol Biochem Behav 1987; 26: 373-379
26. Szreder Z. Antipyresis as a result of alpha-1 adrenoceptor blockade. Gen Pharmacol 1993; 24: 455-460
27. Szreder Z. Comparison of the effect of prazosin with that of dihydrobenzperidol and nifidepine on thermoregulatory responses produced by pyrogen in rabbits. Gen Pharmacol 1990; 21: 833-838
28. Bexis S, Docherty JR. Role of alpha2A-adrenoceptors in the effects of MDMA on body temperature in the mouse. Br J Pharmacol 2005; 146: 1-6
29. Szreder Z. Do cardiovascular mechanisms participate in thermoregulatory activity of alpha 2-adrenoceptor agonists and antagonists in rabbits? Ann N Y Acad Sci 1997; 813: 512-525
30. Gagalo I, Szreder Z. The effect of doxazosin, urapidil and indoramin pretreatment on fever produced by E. coli lipopolysaccharide in rabbits. Gen Pharmacol 1991; 22: 923-927
31. Dunn AJ. The role of interleukin-1 and tumor necrosis factor alpha in the neurochemical and neuroendocrine responses to endotoxin. Brain Res Bull 1992; 29: 807-812
32. Shido O, Romanovsky AA, Ungar AL, Blatteis CM. Role of intrapreoptic norepinephrine in endotoxin-induced fever in guinea pigs. Am J Physiol 1993; 265: R1369-75
33. Nonogaki K, Iguchi A, Sakamoto N. Effects of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F2 alpha in rats. Eur J Pharmacol 1994; 262: 177-180
34. Myers RD. Neurochemistry of thermoregulation. Physiologist 1984; 27: 41-46
35. Kobinger W. Central alpha-adrenergic systems as targets for hypotensive drugs. Rev Physiol Biochem Pharmacol 1978; 81: 39-100
36. Hasko G, Elenkov IJ, Kvetan V, Vizi ES. Differential effect of selective block of alpha 2-adrenoreceptors on plasma levels of tumour necrosis factor-alpha, interleukin-6 and corticosterone induced by bacterial lipopolysaccharide in mice. J Endocrinol 1995; 144: 457-462
37. Al-Damluji S, Perry L, Tomlin S, et al. Alpha-adrenergic stimulation of corticotropin secretion by a specific central mechanism in man. Neuroendocrinology 1987; 45: 68-76
38. Al-Damluji S, Thomas R, White A, Besser M. Vasopressin mediates alpha 1-adrenergic stimulation of adrenocorticotropin secretion. Endocrinology 1990; 126: 1989-1995
39. Alexander SL, Irvine CH. The effect of the alpha-2-adrenergic agonist, clonidine, on secretion patterns and rates of adrenocorticotropic hormone and its secretagogues in the horse. J Neuroendocrinol 2000; 12: 874-880
40. Feldman S, Weidenfeld J. Involvement of amygdalar alpha adrenoceptors in hypothalamo-pituitary-adrenocortical responses. Neuroreport 1996; 7: 3055-3057
41. Szafarczyk A, Malaval F, Laurent A, Gibaud R, Assenmacher I. Further evidence for a central stimulatory action of catecholamines on adrenocorticotropin release in the rat. Endocrinology 1987; 121: 883-892
42. Takao T, Hashimoto K, Ota Z. Central catecholaminergic control of ACTH secretion. Regul Pept 1988; 21: 301-308
43. Kiem DT, Barna I, Koenig JI, Makara GB. Adrenocorticotropin, prolactin and beta-endorphin stimulatory actions of alpha-2-adrenoceptor antagonists. Neuroendocrinology 1995; 61: 152-158