Potentiation of barbiturate-induced alterations in presynaptic noradrenergic function in rat frontal cortex by imidazol(in)e α2-adrenoceptor agonists

British Journal of Pharmacology

Volumn 125, Issue 3, 1998, Pages 441-446

  Dalley, J W ^b,d   Parker, C A ^a   Wulfert E ^c   Hudson, A L ^a   Nutt, D J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UCB PHARMA   (Belgium)

^d UK   (United Kingdom)

Author keywords

Anaesthesia; Clonidine; GABA; Mivazerol; Noradrenaline; Pentobarbitone

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; IMIDAZOLINE RECEPTOR; MIVAZEROL; NORADRENALIN; PENTOBARBITAL; TETRODOTOXIN;

ANIMAL EXPERIMENT; ARTICLE; DIALYSATE; EYELID REFLEX; FRONTAL CORTEX; GENERAL ANESTHESIA; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BARBITURATES; CEREBRAL CORTEX; DRUG SYNERGISM; IMIDAZOLES; MALE; PENTOBARBITAL; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, PRESYNAPTIC;

EID: 0031709869     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702091     Document Type: Article

References (32)

1. BLAUSTEIN, M.P. & ECTOR, A.C. (1975). Barbiturate inhibition of calcium uptake by depolarised nerve terminals in vitro. Mol. Pharmacol., 11, 369-378.
2. 2+] in cultured rat hippocampal neurones. Neuropharmacology, 34, 541-551.
3. BROWN, D.A., DUNN, P.M. & MARSH, S. (1982) Possible electrophysiological mechanisms for modulating transmitter release. In Presynaptic Receptors: Mechanisms and Functions, ed. de Belleroche, J. 207-218. Chichester, England: Ellis Horwood Ltd.
4. BROWNING, M.D., BUREAU, M., DUDEK, E.M. & OLSEN, R.W. (1990). Protein kinase C and cAMP-dependent protein kinase phosphorylate the β subunit of the purified γ-aminobutyric acid A receptor. Proc. Natl. Acad. Sci., 87, 1315-1318.
5. 2-adrenoceptor agonists. Br. J. Pharmacol., 119, 38P.
6. 2-adrenoceptor agonists, medetomidine, clonidine and UK 14,304 on extraneuronal levels of noradrenaline in the rat frontal cortex: evaluation using in vivo microdialysis and synaptosomal uptake studies. Br. J. Pharmacol., 114, 1717-1723.
7. DE BOER, T., STOOF, J.C. & VAN DUIJN, H. (1982). The effects of convulsant and anticonvulsant drugs on the release of radiolabelled GABA, glutamate, noradrenaline, serotonin and acetylcholine from rat cortical slices. Brain Research, 253, 153-160.
8. DEVCIC, A., SCHMELING, W.T., KAMPINE, J.P. & WARLTIER, D.C. (1994). Oral dexmedetomidine preserves baroreceptor function and decreases anaesthetic requirements of halothane-anaesthetized dogs. Anaesthesiology, 81, 419-430.
9. DOZE, V.A., CHEN, B.-X. & MAZE, M. (1989). Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors. Anaesthesiology, 71, 75-79.
10. FRANKS, N.P. & LIEB, W.R. (1994). Molecular and cellular mechanisms of general anesthesia. Nature, 367, 607-613.
11. GHIGNONE, M., QUINTIN, L., DUKE, P.C., KEHLER, C.H. & CALVILLO, O. (1986). Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anesthesia and endotracheal intubation. Anaesthesiology, 64, 36-42.
12. HAYCOCK, J.W., LEVY, W.B. & COTMAN, C.W. (1977). Pentobarbital depression of stimulus-secretion coupling in brain-selective inhibition of depolarisation-induced calcium-dependent release. Biochem. Pharmacol., 26, 159-161.
13. 3]-noradrenaline from rat brain slices. Br. J. Pharmacol., 101, 567P.
14. KHARASCH, E.D., HILL, H.F. & EDDY, A.C. (1991). Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism. Anaesthesiology, 75, 520-524.
15. KIRKNESS, E.F., BOVENKERK, C.F., UEDA, T. & TURNER, A.J. (1989). Phosphorylation of γ-aminobutyrate (GABA)/benzodiazepine receptors by cyclic AMP-dependent protein kinase. Biochem. J., 259, 613-616.
16. 36Cl uptake by brain microsacs. J. Neurochem., 57, 722-725.
17. LIDBRINK, P., CORRODI, H., FUXE, K. & OLSON, L. (1972). Barbiturates and meprobamate: decreases in catecholamine turnover of central dopamine and noradrenaline neuronal systems and the influence of immobilization stress. Brain Res., 45, 507-524.
18. MASON, S.T. & ANGEL, A. (1983). Anaesthesia: the role of adrenergic mechanisms. Eur. J. Pharmacol., 91, 29-39.
19. 2-autoreceptors. Eur. J. Pharmacol., 157, 23-29.
20. A-receptor subtypes really occur in the brain. TINS 19, 139-143.
21. 2-adrenergic receptors: binding studies on different human and rat membrane preparations. Neurochem. Int., 24, 221-229.
22. PAN, W.H.T. & LAI, Y.-J. (1495). Anesthetics decreased the microdialysis extraction fraction of norepinephrine but not dopamine in the medial prefrontal cortex. Synapse, 21, 85-92.
23. PAXINOS, G. & WATSON, C. (1986). The Rat Brain in Stereotaxic Coordinates. Sydney, Australia: Academic Press.
24. PELKONEN, O., PUURUNEN, J., ARVELA, P. & LAMMINTAUSTRA, R. (1991). Comparative effects of medetomidine enantiomers on in vitro and in vivo microsomal drug metabolism. Pharmacology and Toxicology, 69, 189-194.
25. PERSSON, T. & WALDECK, B. (1971). A reduced rate of turnover of brain noradrenaline during pentobarbitone anaesthesia. J. Pharm. Pharmac., 23, 377-378.
26. PITTALUGA, A. & RAITERI, M. (1988). Clonidine enhances the release of endogenous γ-aminobutyric acid through alpha-2 and alpha-1 presynaptic adrenoceptors differentially located in rat cerebral cortex subregions. J. Pharm. Exp. Ther., 245, 682-686.
27. A receptor current in mouse spinal neurones. Neuron, 5, 789-796.
28. ROGERSON, T.D., WILKINSON, C.F. & HETARSKI, K. (1977). Steric factors in the inhibitory interaction of imidazoles with microsomal enzymes. Biochem. Pharmacol., 26, 1039-1042.
29. ROIZEN, M.F., WHITE, P.F., EGER, E.I. & BROWNSTEIN, M. (1978). Effects of ablation of serotonin or norepinephrine brain-stem areas on halothane and cyclopropane MACs in rats. Anaesthesiology 49, 252-255.
30. 2-adrenoceptor agonist dexmedetomidine increases the apparent potency of the volatile anaesthetic isoflurane in rats in vivo and in hippocampal slice in vitro. Brain Res., 548, 23-28.
31. SCHEININ, B., LINDGREN, L., RANDEL, T., SCHEININ, H. & SCHEININ, M. (1992). Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and preoperative fentanyl. Br. J. Anaesthesia, 68, 126-131.
32. 2 adrenergic receptor. Anaesthesiology, 69, 818-823.