Interleukin-18 polymorphism and physical functioning in older people: A replication study and meta-analysis

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 64, Issue 11, 2009, Pages 1177-1182

  Thomas, Kate ^a   Rafiq, Sajjad ^b   Frayling, Timothy M ^b   Ebrahim, Shah ^c   Kumari, Meena ^d   Gallacher, John ^e   Ferrucci, Luigi ^f   Bandinelli, Stefania ^g   Wallace, Robert B ^h   Melzer, David ^b   Martin, Richard M ^a   Ben Shlomo, Yoav ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b PENINSULA MEDICAL SCHOOL   (United Kingdom)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e CARDIFF UNIVERSITY   (United Kingdom)

^f NATIONAL INSTITUTE ON AGING   (United States)

^g Azienda Sanitaria di Firenze   (Italy)

^h UNIVERSITY OF IOWA   (United States)

Author keywords

Ageing; Gait speed; IL 18; Interleukin 18 polymorphism; Physical function; Walk time

Indexed keywords

INTERLEUKIN 18;

AGED; ARTICLE; FEMALE; GENETICS; HUMAN; MALE; META ANALYSIS; MIDDLE AGED; REPRODUCIBILITY; SINGLE NUCLEOTIDE POLYMORPHISM; WALKING;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; INTERLEUKIN-18; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; WALKING;

EID: 70350454764     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glp092     Document Type: Article

References (19)

1. Gracie JA , Robertson SE , McInnes IB . Interleukin-18 . J Leukoc Biol . 2003 ; 73 ( 2 ): 213-224 .
2. Frayling TM , Rafi q S , Murray A , et al . An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people . J Gerontol A Biol Sci Med Sci . 2007 ; 62 ( 1 ): 73-78 .
3. Ferrucci L , Corsi A , Lauretani F , et al . The origins of age-related proinfl ammatory state . Blood . 2005 ; 105 ( 6 ): 2294-2299 .
4. Blankenberg S , Luc G , Ducimetiere P , et al . Interleukin-18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) . Circulation . 2003 ; 108 ( 20 ): 2453-2459 .
5. Liew FY , Wei XQ , McInnes IB . Role of interleukin 18 in rheumatoid arthritis . Ann Rheum Dis . 2003 ; 62 ( suppl 2 ) : ii48 - ii50 .
6. Caruso C , Lio D , Cavallone L , Franceschi C . Aging, longevity, infl ammation, and cancer . Ann N Y Acad Sci . 2004 ; 1028 : 1-13 .
7. Dinarello CA . Interleukin 1 and interleukin 18 as mediators of infl ammation and the aging process . Am J Clin Nutr . 2006 ; 83 ( 2 ): 447S - 455S .
8. Davey Smith G , Ebrahim S . ' Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol . 2003 ; 32 ( 1 ): 1-22 .
9. Marmot M , Banks J , Blundell R , Lessof C , Nazroo J . Health, Wealth and Lifestyles of the Older Population in England: The 2002 English Longitudinal Study of Ageing . London : Institute for Fiscal Studies ; 2002 .
10. Caerphilly and Speedwell Collaborative Group . Caerphilly and Speedwell collaborative heart disease studies . J Epidemiol Community Health . 1984 ; 38 ( 3 ): 259-262 .
11. Rowett Research Institute . Family diet and health in pre-war Britain. Carnegie United Kingdom Trust Dunfermline . 1955 .
12. Martin RM , Gunnell D , Pemberton J , Frankel S , Davey SG . Cohort profi le: the Boyd Orr cohort - an historical cohort study based on the 65 year follow-up of the Carnegie Survey of Diet and Health (1937-39) . Int J Epidemiol . 2005 ; 34 ( 4 ): 742-749 .
13. Ferrucci L , Bandinelli S , Benvenuti E , et al . Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study . J Am Geriatr Soc . 2000 ; 48 ( 12 ): 1618-1625 .
14. Cornoni-Huntley J , Ostfeld AM , Taylor JO , et al . Established populations for epidemiologic studies of the elderly: study design and methodology. Aging (Milano) . 1993 ; 5 ( 1 ): 27-37 .
15. Podsiadlo D , Richardson S . The timed " Up & Go " : a test of basic functional mobility for frail elderly persons . J Am Geriatr Soc . 1991 ; 39 ( 2 ): 142-148 .
16. Higgins JP , Thompson SG , Deeks JJ , Altman DG . Measuring inconsistency in meta-analyses . BMJ . 2003 ; 327 ( 7414 ): 557-560 .
17. Higgins JP , Thompson SG . Quantifying heterogeneity in a metaanalysis. Stat Med . 2002 ; 21 ( 11 ): 1539-1558 .
18. Hirschhorn JN , Lohmueller K , Byrne E , Hirschhorn K . A comprehensive review of genetic association studies . Genet Med . 2002 ; 4 ( 2 ): 45-61 .
19. Ioannidis JP . Genetic associations: false or true? Trends Mol Med . 2003 ; 9 ( 4 ): 135-138 .