Polymorphisms in VKORC1 and GGCX are not major genetic determinants of vitamin K-dependent coagulation factor activity in Western Germans

Thrombosis and Haemostasis

Volumn 102, Issue 2, 2009, Pages 418-420

  Watzka, Matthias ^a   Westhofen, Philipp ^a   Hass, Moritz ^a   Marinova, Milka ^a   Pötzsch, Bernd ^a   Oldenburg, Johannes ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 9; PROTEIN C; PROTHROMBIN; VITAMIN K GROUP; GLUTAMYL CARBOXYLASE; LIGASE; MENADIONE EPOXIDASE; MIXED FUNCTION OXIDASE;

ADULT; AGED; ALLELE; BLOOD CLOTTING; FEMALE; GENE; GENE INSERTION; GENETIC POLYMORPHISM; GENOTYPE; GERMANY; GGCX GENE; HAPLOTYPE; HETEROZYGOSITY; HUMAN; LETTER; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; VKORC1 GENE; GENETICS; METABOLISM; MIDDLE AGED;

ADULT; BLOOD COAGULATION FACTORS; CARBON-CARBON LIGASES; FEMALE; GERMANY; HUMANS; MALE; MIDDLE AGED; MIXED FUNCTION OXYGENASES; POLYMORPHISM, SINGLE NUCLEOTIDE; VITAMIN K;

EID: 70350448759     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH09-04-0217     Document Type: Letter

References (19)

1. Wang Y, Zhang W, Zhang Y, et al. VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection). Circulation 2006; 113: 1615-1621. (Pubitemid 43739421)
2. Kinoshita H, Nakagawa K, Narusawa K, et al. A functional single nucleotide polymorphism in the vitamin-K-dependent gamma-glutamyl carboxylase gene (Arg325Gln) is associated with bone mineral density in elderly Japanese women. Bone 2007; 40: 451-456. (Pubitemid 46054548)
3. Rost S, Fregin A, Ivaskevicius V, et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 2004; 427: 537-541. (Pubitemid 38209110)
4. Li T, Chang CY, Jin DY, et al. Identification of the gene for vitamin K epoxide reductase. Nature 2004; 427: 541-544. (Pubitemid 38209111)
5. Wu SM, Cheung WF, Frazier D, et al. Cloning and expression of the cDNA for human gamma-glutamyl carboxylase. Science 1991; 254: 1634-1636. (Pubitemid 21917505)
6. Wallin R. Vitamin K antagonism of coumarin anti-coagulation. A dehydrogenase pathway in rat liver is responsible for the antagonistic effect. Biochem J 1986; 236: 685-693.
7. Geisen C, Watzka M, Sittinger K, et al. VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation. Thromb Haemost 2005; 94: 773-779. (Pubitemid 41489236)
8. Rieder MJ, Reiner AP, Gage BF, et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med 2005; 352: 2285-2293.
9. Yuan HY, Chen JJ, Lee MT, et al. A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity. Hum Mol Genet 2005; 14: 1745-1751.
10. Traver RD, Siegel D, Beall HD, et al. Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase). Br J Cancer 1997; 75: 69-75. (Pubitemid 27007275)
11. Humphries S, Temple A, Lane A, et al. Low plasma levels of factor VIIc and antigen are more strongly associated with the 10 base pair promoter (-323) insertion than the glutamine 353 variant. Thromb Haemost 1996; 75: 567-572. (Pubitemid 26138261)
12. Oldenburg J, Watzka M, Rost S, et al. VKORC1: molecular target of coumarins. J Thromb Haemost 2007; 5 (Suppl 1): 1-6.
13. Wadelius M, Chen LY, Eriksson N, et al. Association of warfarin dose with genes involved in its action and metabolism. Hum Genet 2007; 121: 23-34. (Pubitemid 46421137)
14. Momary KM, Shapiro NL, Viana MA, et al. Factors influencing warfarin dose requirements in African-Americans. Pharmacogenomics 2007; 8: 1535-1544. (Pubitemid 350286397)
15. Kimura R, Kokubo Y, Miyashita K, et al. Polymorphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general population. Int J Hematol 2006; 84: 387-397. (Pubitemid 46052627)
16. Watzka M, Nebel A, El Mokhtari NE, et al. Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans. Thromb Haemost 2007; 97: 998-1002. (Pubitemid 46939214)
17. Arnold ML, Lichy C, Werner I, et al. Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population. Thromb Haemost 2008; 100: 614-617.
18. Smadja DM, Loriot MA, Hindorff LA, et al. No clear link between VKORC1 genetic polymorphism and the risk of venous thrombosis or peripheral arterial disease. Thromb Haemost 2008; 99: 970-972
19. Nimptsch K, Nieters A, Hailer S, et al. The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype. Br J Nutr. 2008; Epub ahead of print, doi:10.1017/S0007114508131750.