Amlodipine besylate/olmesartan medoximil fixed combination for the treatment of hypertension

Expert Review of Cardiovascular Therapy

Volumn 7, Issue 8, 2009, Pages 887-895

  Chrysant, Steven G ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Amlodipine besylate; Angiotensin receptor blocker; Combination therapy; Hypertension; Olmesartan medoxomil

Indexed keywords

AMLODIPINE BESYLATE; AMLODIPINE PLUS OLMESARTAN; AMLODIPINE PLUS TELMISARTAN; AMLODIPINE PLUS VALSARTAN; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; DIHYDROPYRIDINE DERIVATIVE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDRALAZINE; HYDRALAZINE PLUS HYDROCHLOROTHIAZIDE PLUS RESERPINE; HYDROCHLOROTHIAZIDE; OLMESARTAN; PLACEBO; RESERPINE; UNCLASSIFIED DRUG; AMLODIPINE; CALCIUM CHANNEL BLOCKING AGENT; IMIDAZOLE DERIVATIVE; TETRAZOLE DERIVATIVE;

BLOOD PRESSURE REGULATION; CLINICAL TRIAL; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DIZZINESS; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EDEMA; FATIGUE; FOOT EDEMA; HUMAN; HYPERTENSION; INFECTION; MONOTHERAPY; MUSCULOSKELETAL DISEASE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SYSTOLIC BLOOD PRESSURE; UNSPECIFIED SIDE EFFECT; AGED; ARTICLE; BLOOD PRESSURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; DRUG EFFECT; FEMALE; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PRACTICE GUIDELINE; RANDOMIZED CONTROLLED TRIAL;

AGED; AMLODIPINE; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; EDEMA; FEMALE; HUMANS; HYPERTENSION; IMIDAZOLES; MALE; MIDDLE AGED; PRACTICE GUIDELINES AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TETRAZOLES;

EID: 70350448676     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/erc.09.85     Document Type: Review

References (30)

1. Chobanian AV, Bakris GL, Black HR et al. Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 42, 1206-1252 (2003). • Important US guidelines for the treatment of hypertension.
2. Mancia G, DeBecker G, Dominiczak A et al. 2007 guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. Hypertens. 25, 1105-1187 (2007). • Important European guidelines for the treatment of hypertension.
3. Ong KL, Cheung BM, Man YB, Lau CP, Lam KS. Prevalence, awareness; treatment, and control of hypertension among United States adults 1999-2004. Hypertension 49, 69-75 (2007). • Important recent survey for the incidence of hypertension in the USA.
4. Materson BJ, Reda DJ, Cushman WC et al.; The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. N. Engl. J. Med. 328, 914-921 (1993).
5. Chrysant SG, Melino M, Karki S, Lee J, Heyrman R. The combination of olmesartan medoxomil and amlodipine besylate in controlling high blood pressure: COACH, a randomized, double-blind, placebo-controlled, 8 week factorial efficacy and safety study. Clin. Ther. 30, 587-604 (2008). •• Original publication of the Combination of Olmesartan medoxomil and Amlodipine besylate in Controlling High blood pressure (COACH) study providing more information on the combination of olmesartan with amlodipine for the treatment of hypertension.
6. Philipp T, Smith TR, Glazer R et al. Two multicenter, 8-week, randomized, double-blind, placebo controlled, parallel group studies evaluating the efficacy and tolerability of amlodipine and valsartan in combination and as monotherapy in adult patients with mild to moderate essential hypertension. Clin. Ther. 29, 563-580 (2007). •• Important, large, randomized study providing detailed information on the antihypertensive effectiveness of valsartan with amlodipine.
7. Destro M, Lukow A, Samson A, Kandra A, Brunel P. Efficacy and safety of amlodipine/ valsartan compared with amlodipine monotherapy in patients with stage 2 hypertension: a randomized double-blind, multicenter study EX-EFFECTS study. J. Am. Soc. Hypertens. 2, 294-302 (2008).
8. Littlejohn TW, Mazul CR, Olvera R et al. Telmisartan plus amlodipine in patients with moderate or severe hypertension: results from a subgroup analysis of a randomized placebo-controlled parallel group, 4 x 4 factorial study. Postgrad. Med. 121, 5-14 (2009). •• Important, large, randomized study providing detailed information on the antihypertensive effectiveness of telmisartan with amlodipine.
9. Ausubel H, Levine ML. Treatment of hypertension with Ser-Ap-Es. Curr. Ther. Clin. Exp. 9, 29-35 (1967).
10. Chrysant SG. Using fixed-dose combination therapies to achieve blood pressure goals. Clin. Drug Invest. 28, 713-734 (2008).
11. Gradman AH, Cutler NR, Davis PJ, Robbins JA, Weis RJ, Wood BC. Combined enalapril and felodipine extended release (ER) for systemic hypertension. Enalapril-Felodipine-ER Factorial Study Group. Am. J. Cardiol. 79, 431-435 (1997).
12. Chrysant SG, Bakris GL. Amlodipine/ benazepril monotherapy. Am. J. Hypertens. 17, 590-596 (2004).
13. Chrysant SG, Gavras H, Niederman AI, Marbury TC, Goldstein R. Clinical utility of long-term enalapril/diltaizem ER in stage 3-4 essential hypertension. J. Clin. Pharmacol. 37, 810-815 (1997). (Pubitemid 27441137)
14. DeQuattro V, Lee D, Messerli FH; The Trandolapril Study Group. Fixed-dose combination therapy with trandolapril and verapamil SR in primary hypertension. A 4 x 4 trail design. Clin. Exp. Hypertens. 19, 373-387 (1999).
15. Chrysant SG, Sugimoto DH, Lefkowitz M et al. The effects of high-dose amlodipine/ benazepril combination therapies on blood pressure reduction in patients not adequately controlled with amlodipine monotherapy. Blood Press. 16(Suppl. 1), 10-17 (2007). (Pubitemid 46705167)
16. Moser M. From JNC1 to JNC7. What have we learned? Prog. Cardiovasc. Dis. 48, 303-315 (2006).
17. Fagan TC. Remembering the lessons of basic pharmacology. Arch. Intern. Med. 154, 1430-1431 (1994).
18. Chrysant SG. Fixed low-dose drug combination for the treatment of hypertension. Arch. Fam. Med. 7, 370-376 (1998).
19. Sica DA. Fixed-dose combination of antihypertensive drugs. Do they have a role in rational therapy? Drugs 48, 16-24 (1994).
20. Epstein M, Bakris G. Newer approaches to antihypertensive therapy. Use of fixed-dose combination therapy. Arch. Intern. Med. 156, 1969-1978 (1996).
21. Messerli FH. Combination therapy in hypertension. J. Hum. Hypertens. 6(Suppl. 2), S19-S21 (1992).
22. Chrysant SG, Cohen M. Sustained blood pressure control with controlled-release isradipine (isradipine CR). J. Clin. Pharmacol. 35, 239-243 (1995).
23. Chrysant SG, Marbury TC, Robinson TD. Antihypertensive efficacy and safety of olmesartan medoxomil compared to amlodipine for mild-to-moderate hypertension. J. Hum. Hypertens. 17, 425-432 (2003).
24. Chrysant SG. Proactive compared with passive event recognition: calcium channel blocker associated edema. J. Clin. Hypertens. 10, 16-22 (2008).
25. Cappuccio FP, Markandu ND, Sagnella GA et al. Effects of amlodipine on urinary sodium excretion, reninangiotensin- aldosterone system, atrial natriuretic peptide and blood pressure in essential hypertension. J. Hum. Hypertens. 5, 115-119 (1996). • Good study of some of the pathophysiologic properties of amlodipine regarding its antihypertensive effect.
26. Chrysant SG. Using fixed-dose combination therapies to achieve blood pressure control. Clin. Drug Invest. 28, 713-734 (2008).
27. Bagalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am. J. Med. 120, 713-719 (2007). (Pubitemid 47176510)
28. Lewington S, Clarke R, Orizilbash N et al.; Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a metaanalysis of individual data from one million adults in 61 prospective studies. Lancet 360, 1903-1913 (2002).
29. Jamerson K, Weber MA, Bakris GL et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high risk patients. N. Engl. J. Med. 359, 2417-2428 (2008).
30. Fogari R, Zoppi A, Derosa G et al. Effect of valsartan addition to amlodipine on ankle oedema and subcutaneous tissue pressure in hypertensive patients. J. Hum. Hypert. 21, 220-224 (2007). •• Important study regarding the objective evidence of pedal edema with amlodipine and its amelioration with the combination of valsartan.