Combined Enalapril and Felodipine Extended Release (ER) for Systemic Hypertension

American Journal of Cardiology

Volumn 79, Issue 4, 1997, Pages 431-435

  Gradman, Alan H ^a   Cutler, Neal R ^b   Davis, Pamela J ^b   Robbins, John A ^b   Weiss, Robert J ^b   Wood, Barry C ^b  

^a WESTERN PENNSYLVANIA HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; ENALAPRIL; FELODIPINE;

AGED; ARTICLE; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED RELEASE FORMULATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; DRUG EFFECT; FEMALE; HUMAN; HYPERTENSION; MALE; MIDDLE AGED; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL;

AGED; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ENALAPRIL; FELODIPINE; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED;

EID: 0031568452     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(96)00781-3     Document Type: Article

References (16)

1. Fouad FM, Tarazi RC. Cardiac factors in response to antihypertensive treatment. Hypertension 1983;5(suppl III):43-48.
2. Brunner HR, Ménard J, Waeber B, Burnier M, Biollaz J, Nussberger J, Bellet M. Treatment the individual hypertensive patient: considerations on dose sequential monotherapy and drug combinations. J Hypertens 1990; 8:3-11.
3. Anderson A, Morgan T. Interaction of enalapril with sodium restriction, diuretics, and slow-channel calcium-blocking drugs. Nephron 1990;55(suppl 1):70-72.
4. Dengler HJ, Lasagna L. Report of a workshop on fixed-ratio drug combinations. Eur J Clin Pharmacol 1975;8:140-154.
5. Dollery CT. Pharmacological basis for combination therapy of hypertension. Annu Rev Pharmacol Toxicol 1977;17:311-323.
6. Frishman WH, Bryzinski BS, Coulson LR, DeQuattro VL, Vlachakis ND, Mroczek WJ, Dukart G, Goldberg JD, Alemayehu D, Koury K. A multifactorial trial design to assess combination therapy in hypertension. Arch Intern Med 1994;154:1461-1468.
7. Ménard J, Bellet M. Calcium antagonists-ACE inhibitors combination therapy: objectives and methodology of clinical development. J Cardiovasc Pharmacol 1993;21(suppl 2);49-54.
8. Sica DA. Fixed-dose combination antihypertensive drugs. Drugs 1994; 48(1):16-24.
9. Morgan TO, Anderson A, Jones E. Comparison and interaction of low dose felodipine and enalapril in the treatment of essential hypertension in elderly subjects. Am J Hypertens 1992;5:238-243.
10. Burris JF, Weir MR, Oparil S, Weber M, Cady WJ, Steward WH. An assessment of diltiazem and hydrochlorothiazide in hypertension: application of factorial trial design to a multicenter clinical trial of combination therapy. JAMA 1990;263:1507-1512.
11. Gradman AH. Hemodynamic effects of the vascular selective calcium antagonist felodipine in patients with impaired left ventricular function. Am Heart J 1992;123:273-278.
12. Guazzi MD, DeCesare N, Galli C, Salvioni A, Tramontana C, Tamborini G, Bartorelli A. Calcium-channel blockade with nifedipine and angiotensin converting-enzyme inhibition with captopril in the therapy of patients with severe primary hypertension. Circulation 1984;70:279-284.
13. Saunders E, Weir M, Kong BW, Hillifield J, Gray J, Vertes V, Sowers JR, Zemel MB, Curry C, Schoenberger J, Wright J, Kirkendall W, Conradi EC, Jenkins P, McLean B, Berenson G, Flamenbaum W. A comparison of the efficacy and safety of a β-blocker, a calcium channel blocker and a converting enzyme inhibitor in hypertensive blacks. Arch Intern Med 1990;150:1707-1713.
14. Hansson L, Dahlöf B. Calcium Antagonists in the treatment of hypertension: state of the art. J Cardiovasc Pharmacol 1990(suppl 4);15:71-75.
15. Applegate WB, Phillips HL, Schnaper H, Shepherd AMM, Schocken D, Challop-Luhr J, Koch GG, Park GD. A randomized controlled trial of the effects of three antihypertensive agents on blood pressure control and quality of life in older women. Arch Intern Med 1991;151:1817-1823.
16. Wade JR, Sambol MC. Felodipine population dose-response and concentration- response relationships in patients with essential hypertension. Clin Pharmacol Therapeut 1995;57:569-581.