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Volumn 28, Issue 11, 2009, Pages 543-553

Endothelin-1 impairs nitric oxide signaling in endothelial cells through a protein kinase cδ-dependent activation of STAT3 and decreased endothelial nitric oxide synthase expression

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; NITRIC OXIDE; PROTEIN KINASE C DELTA; STAT3 PROTEIN;

EID: 70350440292     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2009.0865     Document Type: Article
Times cited : (44)

References (60)
  • 1
    • 0025696993 scopus 로고
    • Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth
    • Abman, S.H., Chatfield, B.A., Hall, S.L., and McMurtry, I.F. (1990 Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am J Physiol 259, H1921-H1927.
    • (1990) Am J Physiol , vol.259
    • Abman, S.H.1    Chatfield, B.A.2    Hall, S.L.3    McMurtry, I.F.4
  • 2
    • 0027499701 scopus 로고
    • The human endothelin-B receptor gene. Structural organization and chromosomal assignment
    • Arai, H., Nakao, K., Takaya, K., Hosoda, K., Ogawa, Y., Nakanishi, S., and Imura, H. (1993 The human endothelin-B receptor gene. Structural organization and chromosomal assignment. J Biol Chem 268, 3463-3470.
    • (1993) J Biol Chem , vol.268 , pp. 3463-3470
    • Arai, H.1    Nakao, K.2    Takaya, K.3    Hosoda, K.4    Ogawa, Y.5    Nakanishi, S.6    Imura, H.7
  • 4
    • 0031724886 scopus 로고    scopus 로고
    • Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension
    • Black, S.M., Fineman, J.R., Steinhorn, R.H., Bristow, J., and Soifer, S.J. (1998a Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol 275, H1643-H1651.
    • (1998) Am J Physiol , vol.275
    • Black, S.M.1    Fineman, J.R.2    Steinhorn, R.H.3    Bristow, J.4    Soifer, S.J.5
  • 5
    • 0030875453 scopus 로고    scopus 로고
    • Ventilation and oxygenation induce endothelial nitric oxide synthase gene expression in the lungs of fetal lambs
    • Black, S.M., Johengen, M.J., Ma, Z.D., Bristow, J., and Soifer, S.J. (1997 Ventilation and oxygenation induce endothelial nitric oxide synthase gene expression in the lungs of fetal lambs. J Clin Invest 100, 1448-1458.
    • (1997) J Clin Invest , vol.100 , pp. 1448-1458
    • Black, S.M.1    Johengen, M.J.2    Ma, Z.D.3    Bristow, J.4    Soifer, S.J.5
  • 6
    • 0031755388 scopus 로고    scopus 로고
    • Coordinated regulation of genes of the nitric oxide and endothelin pathways during the development of pulmonary hypertension in fetal lambs
    • Black, S.M., Johengen, M.J., and Soifer, S.J. (1998b Coordinated regulation of genes of the nitric oxide and endothelin pathways during the development of pulmonary hypertension in fetal lambs. Pediatr Res 44, 821-830.
    • (1998) Pediatr Res , vol.44 , pp. 821-830
    • Black, S.M.1    Johengen, M.J.2    Soifer, S.J.3
  • 8
    • 0025100874 scopus 로고
    • Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide
    • Boulanger, C., and Luscher, T.F. (1990 Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J Clin Invest 85, 587-590.
    • (1990) J Clin Invest , vol.85 , pp. 587-590
    • Boulanger, C.1    Luscher, T.F.2
  • 9
    • 0026089590 scopus 로고
    • Tone-dependent responses to endothelin in the isolated perfused fetal sheep pulmonary circulation in situ
    • Cassin, S., Kristova, V., Davis, T., Kadowitz, P., and Gause, G. (1991 Tone-dependent responses to endothelin in the isolated perfused fetal sheep pulmonary circulation in situ. J Appl Physiol 70, 1228-1234.
    • (1991) J Appl Physiol , vol.70 , pp. 1228-1234
    • Cassin, S.1    Kristova, V.2    Davis, T.3    Kadowitz, P.4    Gause, G.5
  • 11
    • 0028181105 scopus 로고
    • Characterization of two endothelin converting enzymes and their preference for big endothelin-1 and-2 as substrates
    • Chiou, W.J., Shiosaki, K., Tasker, A.S., and Wu-Wong, J.R. (1994 Characterization of two endothelin converting enzymes and their preference for big endothelin-1 and-2 as substrates. Life Sci 54, 1613-1619.
    • (1994) Life Sci , vol.54 , pp. 1613-1619
    • Chiou, W.J.1    Shiosaki, K.2    Tasker, A.S.3    Wu-Wong, J.R.4
  • 12
    • 0030728992 scopus 로고    scopus 로고
    • Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 50-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension
    • Christou, H., Adatia, I., van Marter, L.J., Kane, J.W., Thompson, J.E., Stark, A.R., Wessel, D.L., and Kourembanas, S. (1997 Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 50-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension. J Pediatr 130, 603-611.
    • (1997) J Pediatr , vol.130 , pp. 603-611
    • Christou, H.1    Adatia, I.2    Van Marter, L.J.3    Kane, J.W.4    Thompson, J.E.5    Stark, A.R.6    Wessel, D.L.7    Kourembanas, S.8
  • 13
    • 21244456905 scopus 로고    scopus 로고
    • Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: Role of ETB receptor, NADPH oxidase and caveolin-1
    • Dong, F., Zhang, X., Wold, L.E., Ren, Q., Zhang, Z., and Ren, J. (2005 Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: Role of ETB receptor, NADPH oxidase and caveolin-1. Br J Pharmacol 145, 323-333.
    • (2005) Br J Pharmacol , vol.145 , pp. 323-333
    • Dong, F.1    Zhang, X.2    Wold, L.E.3    Ren, Q.4    Zhang, Z.5    Ren, J.6
  • 14
    • 0013635442 scopus 로고    scopus 로고
    • Pulmonary Hypertension
    • A.H. Emmanouilides T.A. Riemenschneider, and H.P. Gutgesell, eds. (Williams & Wilkens, Baltimore, MD)
    • Fineman, J., Heymann, M., and Morin, F.I. (2001 Pulmonary Hypertension. Moss and Adams, Heart Disease in Infants, Children, and Adolescents. A.H. Emmanouilides T.A. Riemenschneider, and H.P. Gutgesell, eds. (Williams & Wilkens, Baltimore, MD) pp. 41-53.
    • (2001) Moss and Adams, Heart Disease in Infants, Children, and Adolescents , pp. 41-53
    • Fineman, J.1    Heymann, M.2    Morin, F.I.3
  • 15
    • 0028935785 scopus 로고
    • Regulation of pulmonary vascular tone in the perinatal period
    • Fineman, J.R., Soifer, S.J., and Heymann, M.A. (1995 Regulation of pulmonary vascular tone in the perinatal period. Annu Rev Physiol 57, 115-134.
    • (1995) Annu Rev Physiol , vol.57 , pp. 115-134
    • Fineman, J.R.1    Soifer, S.J.2    Heymann, M.A.3
  • 16
    • 33644990745 scopus 로고    scopus 로고
    • The role of protein kinase C delta activation and STAT3 Ser727 phosphorylation in insulin- induced keratinocyte proliferation
    • Gartsbein, M., Alt, A., Hashimoto, K., Nakajima, K., Kuroki, T., and Tennenbaum, T. (2006 The role of protein kinase C delta activation and STAT3 Ser727 phosphorylation in insulin- induced keratinocyte proliferation. J Cell Sci 119, 470-481.
    • (2006) J Cell Sci , vol.119 , pp. 470-481
    • Gartsbein, M.1    Alt, A.2    Hashimoto, K.3    Nakajima, K.4    Kuroki, T.5    Tennenbaum, T.6
  • 18
    • 32944479992 scopus 로고    scopus 로고
    • Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells
    • Isomoto, H., Kobayashi, S., Werneburg, N.W., Bronk, S.F., Guicciardi, M.E., Frank, D.A., and Gores, G.J. (2005 Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology 42, 1329-1338.
    • (2005) Hepatology , vol.42 , pp. 1329-1338
    • Isomoto, H.1    Kobayashi, S.2    Werneburg, N.W.3    Bronk, S.F.4    Guicciardi, M.E.5    Frank, D.A.6    Gores, G.J.7
  • 19
    • 0032542211 scopus 로고    scopus 로고
    • Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK
    • Jain, N., Zhang, T., Fong, S.L., Lim, C.P., and Cao, X. (1998 Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK Oncogene 17, 3157-3167.
    • (1998) Oncogene , vol.17 , pp. 3157-3167
    • Jain, N.1    Zhang, T.2    Fong, S.L.3    Lim, C.P.4    Cao, X.5
  • 20
    • 0033588229 scopus 로고    scopus 로고
    • Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner
    • Jain, N., Zhang, T., Kee, W.H., Li, W., and Cao, X. (1999 Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner. J Biol Chem 274, 24392-24400.
    • (1999) J Biol Chem , vol.274 , pp. 24392-24400
    • Jain, N.1    Zhang, T.2    Kee, W.H.3    Li, W.4    Cao, X.5
  • 21
    • 1942485280 scopus 로고    scopus 로고
    • Nitric oxide decreases endothelin-1 secretion through the activation of soluble guanylate cyclase
    • Kelly, L.K., Wedgwood, S., Steinhorn, R.H., and Black, S.M. (2004 Nitric oxide decreases endothelin-1 secretion through the activation of soluble guanylate cyclase. Am J Physiol Lung Cell Mol Physiol 286, L984-L991.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Kelly, L.K.1    Wedgwood, S.2    Steinhorn, R.H.3    Black, S.M.4
  • 22
    • 0029820551 scopus 로고    scopus 로고
    • Plasma immunoreactive endothelin-1 concentrations in infants with persistent pulmonary hypertension of the newborn
    • Kumar, P., Kazzi, N.J., and Shankaran, S. (1996 Plasma immunoreactive endothelin-1 concentrations in infants with persistent pulmonary hypertension of the newborn. Am J Perinatol 13, 335-341.
    • (1996) Am J Perinatol , vol.13 , pp. 335-341
    • Kumar, P.1    Kazzi, N.J.2    Shankaran, S.3
  • 23
    • 52149083070 scopus 로고    scopus 로고
    • Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity
    • Kumar, S., Sun, X., Wedgwood, S., and Black, S.M. (2008a Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity. Am J Physiol Lung Cell Mol Physiol 295, L756-L766.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295
    • Kumar, S.1    Sun, X.2    Wedgwood, S.3    Black, S.M.4
  • 24
    • 62249194860 scopus 로고    scopus 로고
    • Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity
    • Kumar, S., Sun, X., Wiseman, D.A., Tian, J., Siddaramappa, U., Verin, A.D., and Black, S.M. (2008b Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity. DNA Cell Biol 28, 119-129.
    • (2008) DNA Cell Biol , vol.28 , pp. 119-129
    • Kumar, S.1    Sun, X.2    Wiseman, D.A.3    Tian, J.4    Siddaramappa, U.5    Verin, A.D.6    Black, S.M.7
  • 28
    • 0032849049 scopus 로고    scopus 로고
    • Tyrosine-kinase-dependent regulation of the nitric oxide synthase gene by endothelin-1 in human endothelial cells
    • Marsen, T.A., Egink, G., Suckau, G., and Baldamus, C.A. (1999 Tyrosine-kinase-dependent regulation of the nitric oxide synthase gene by endothelin-1 in human endothelial cells. Pflugers Arch 438, 538-544.
    • (1999) Pflugers Arch , vol.438 , pp. 538-544
    • Marsen, T.A.1    Egink, G.2    Suckau, G.3    Baldamus, C.A.4
  • 30
    • 0026486453 scopus 로고
    • EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs
    • Moore, P., Velvis, H., Fineman, J.R., Soifer, S.J., and Heymann, M.A. (1992 EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. J Appl Physiol 73, 2151-2157.
    • (1992) J Appl Physiol , vol.73 , pp. 2151-2157
    • Moore, P.1    Velvis, H.2    Fineman, J.R.3    Soifer, S.J.4    Heymann, M.A.5
  • 32
    • 0035467901 scopus 로고    scopus 로고
    • Effects of oxidized low density lipoprotein on nitric oxide synthetase and protein kinase C activities in bovine endothelial cells
    • Mukherjee, S., Coaxum, S.D., Maleque, M., and Das, S.K. (2001 Effects of oxidized low density lipoprotein on nitric oxide synthetase and protein kinase C activities in bovine endothelial cells. Cell Mol Biol (Noisy-le-grand) 47, 1051-1058.
    • (2001) Cell Mol Biol (Noisy-le-grand) , vol.47 , pp. 1051-1058
    • Mukherjee, S.1    Coaxum, S.D.2    Maleque, M.3    Das, S.K.4
  • 33
    • 0019430964 scopus 로고
    • The structural basis of persistent pulmonary hypertension of the newborn infant
    • Murphy, J.D., Rabinovitch, M., Goldstein, J.D., and Reid, L.M. (1981 The structural basis of persistent pulmonary hypertension of the newborn infant. J Pediatr 98, 962-967.
    • (1981) J Pediatr , vol.98 , pp. 962-967
    • Murphy, J.D.1    Rabinovitch, M.2    Goldstein, J.D.3    Reid, L.M.4
  • 34
    • 0029120832 scopus 로고
    • Endothelium-derived vasoactive factors in hypertension: Nitric oxide and endothelin
    • Nava, E., and Luscher, T.F. (1995 Endothelium-derived vasoactive factors in hypertension: nitric oxide and endothelin. J Hypertens Suppl 13, S39-S48.
    • (1995) J Hypertens Suppl , vol.13
    • Nava, E.1    Luscher, T.F.2
  • 35
    • 0029826983 scopus 로고    scopus 로고
    • Systemic hypertension induced by hepatic overexpression of human preproendothelin-1 in rats
    • Niranjan, V., Télémaque, S., deWit, D., Gerard, R.D., and Yanagisawa, M. (1996 Systemic hypertension induced by hepatic overexpression of human preproendothelin-1 in rats. J Clin Invest 98, 2364-2372.
    • (1996) J Clin Invest , vol.98 , pp. 2364-2372
    • Niranjan, V.1    Télémaque, S.2    Dewit, D.3    Gerard, R.D.4    Yanagisawa, M.5
  • 36
    • 0027452151 scopus 로고
    • Purification and characterization of a phosphoramidon-sensitive endothelin-converting enzyme in porcine aortic endothelium
    • Ohnaka, K., Takayanagi, R., Nishikawa, M., Haji, M., and Nawata, H. (1993 Purification and characterization of a phosphoramidon-sensitive endothelin-converting enzyme in porcine aortic endothelium. Off J Biol Chem 268, 26759-26766.
    • (1993) Off J Biol Chem , vol.268 , pp. 26759-26766
    • Ohnaka, K.1    Takayanagi, R.2    Nishikawa, M.3    Haji, M.4    Nawata, H.5
  • 37
    • 59649101405 scopus 로고    scopus 로고
    • Molecular analysis of cocaine-induced endothelial dysfunction: Role of endothelin-1 and nitric oxide
    • Pradhan, L., Mondal, D., Chandra, S., Ali, M., and Agrawal, K.C. (2008 Molecular analysis of cocaine-induced endothelial dysfunction: Role of endothelin-1 and nitric oxide. Cardiovasc Toxicol 8, 161-171.
    • (2008) Cardiovasc Toxicol , vol.8 , pp. 161-171
    • Pradhan, L.1    Mondal, D.2    Chandra, S.3    Ali, M.4    Agrawal, K.C.5
  • 38
    • 33747199921 scopus 로고    scopus 로고
    • Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway
    • Ramzy, D., Rao,V., Tumiati, L.C., Xu,N., Sheshgiri, R.,Miriuka, S., Delgado, D.H., and Ross, H.J. (2006 Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway. Circulation 114, I319-I326.
    • (2006) Circulation , vol.114
    • Raov, R.D.1    Xun, C.T.L.2    Sheshgiri, R.3    Miriuka, S.4    Delgado, D.H.5    Ross, H.J.6
  • 39
    • 0025605930 scopus 로고
    • Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
    • Sakurai, T., Yanagisawa, M., Takuwa, Y., Miyazaki, H., Kimura, S., Goto, K., and Masaki, T. (1990 Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature 348, 732-735.
    • (1990) Nature , vol.348 , pp. 732-735
    • Sakurai, T.1    Yanagisawa, M.2    Takuwa, Y.3    Miyazaki, H.4    Kimura, S.5    Goto, K.6    Masaki, T.7
  • 40
    • 33749560285 scopus 로고    scopus 로고
    • Stat3 mediates interleukin-6 [correction of interleukin-6] inhibition of human endothelial nitric-oxide synthase expression
    • Saura, M., Zaragoza, C., Bao, C., Herranz, B., Rodriguez-Puyol, M., and Lowenstein, C.J. (2006 Stat3 mediates interleukin-6 [correction of interleukin-6] inhibition of human endothelial nitric-oxide synthase expression. J Biol Chem 281, 30057-30062.
    • (2006) J Biol Chem , vol.281 , pp. 30057-30062
    • Saura, M.1    Zaragoza, C.2    Bao, C.3    Herranz, B.4    Rodriguez-Puyol, M.5    Lowenstein, C.J.6
  • 41
    • 0032530159 scopus 로고    scopus 로고
    • Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases
    • Sengupta, T.K., Talbot, E.S., Scherle, P.A., and Ivashkiv, L.B. (1998 Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases. Proc Natl Acad Sci USA 95, 11107-11112.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11107-11112
    • Sengupta, T.K.1    Talbot, E.S.2    Scherle, P.A.3    Ivashkiv, L.B.4
  • 42
    • 0027133839 scopus 로고
    • Pulmonary endothelial nitric oxide production is developmentally regulated in the fetus and newborn
    • Shaul, P.W., Farrar, M.A., and Magness, R.R. (1993 Pulmonary endothelial nitric oxide production is developmentally regulated in the fetus and newborn. Am J Physiol 265, H1056-H1063.
    • (1993) Am J Physiol , vol.265
    • Shaul, P.W.1    Farrar, M.A.2    Magness, R.R.3
  • 43
    • 34250019905 scopus 로고    scopus 로고
    • Cell-type specific interaction of endothelin and the nitric oxide system: Pattern of prepro-ET-1 expression in kidneys of L-NAME treated prepro-ET-1 promoter-lacZ-transgenic mice
    • Slowinski, T., Kalk, P., Christian, M., Schmager, F., Relle, K., Godes, M., Funke-Kaiser, H., Neumayer, H.H., Bauer, C., Theuring, F., and Hocher, B. (2007 Cell-type specific interaction of endothelin and the nitric oxide system: pattern of prepro-ET-1 expression in kidneys of L-NAME treated prepro-ET-1 promoter-lacZ-transgenic mice. J Physiol 581, 1173-1181.
    • (2007) J Physiol , vol.581 , pp. 1173-1181
    • Slowinski, T.1    Kalk, P.2    Christian, M.3    Schmager, F.4    Relle, K.5    Godes, M.6    Funke-Kaiser, H.7    Neumayer, H.H.8    Bauer, C.9    Theuring, F.10    Hocher, B.11
  • 44
    • 64249170535 scopus 로고    scopus 로고
    • Modulation of PKCdelta signaling alters the shear stressmediated increases in endothelial nitric oxide synthase transcription: Role of STAT3
    • Sud, N., Kumar, S., Wedgwood, S., and Black, S.M. (2009 Modulation of PKCdelta signaling alters the shear stressmediated increases in endothelial nitric oxide synthase transcription: Role of STAT3. Am J Physiol Lung Cell Mol Physiol 296, L519-L526.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296
    • Sud, N.1    Kumar, S.2    Wedgwood, S.3    Black, S.M.4
  • 46
    • 41549163846 scopus 로고    scopus 로고
    • Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation
    • Sud, N., Wedgwood, S., and Black, S.M. (2008 Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation. Am J Physiol Lung Cell Mol Physiol 294, L582-L591.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294
    • Sud, N.1    Wedgwood, S.2    Black, S.M.3
  • 47
    • 0030979142 scopus 로고    scopus 로고
    • Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus
    • Villamor, E., Le Cras, T.D., Horan, M.P., Halbower, A.C., Tuder, R.M., and Abman, S.H. (1997 Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus. Am J Physiol 272, L1013-L1020.
    • (1997) Am J Physiol , vol.272
    • Villamor, E.1    Le Cras, T.D.2    Horan, M.P.3    Halbower, A.C.4    Tuder, R.M.5    Abman, S.H.6
  • 48
    • 0029053217 scopus 로고
    • Up-regulation of endothelin-1 mRNA and peptide expression in rat cardiac allografts with rejection and arteriosclerosis
    • Watschinger, B., Sayegh, M.H., Hancock, W.W., and Russell, M.E. (1995 Up-regulation of endothelin-1 mRNA and peptide expression in rat cardiac allografts with rejection and arteriosclerosis. Am J Pathol 146, 1065-1072.
    • (1995) Am J Pathol , vol.146 , pp. 1065-1072
    • Watschinger, B.1    Sayegh, M.H.2    Hancock, W.W.3    Russell, M.E.4
  • 49
    • 0034880404 scopus 로고    scopus 로고
    • Shear stress regulation of endothelial NOS in fetal pulmonary arterial endothelial cells involves PKC
    • Wedgwood, S., Bekker, J.M., and Black, S.M. (2001 Shear stress regulation of endothelial NOS in fetal pulmonary arterial endothelial cells involves PKC. Am J Physiol Lung Cell Mol Physiol 281, L490-L498.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281
    • Wedgwood, S.1    Bekker, J.M.2    Black, S.M.3
  • 50
    • 13644260463 scopus 로고    scopus 로고
    • Endothelin-1 decreases endothelial NOS expression and activity through ETA receptormediated generation of hydrogen peroxide
    • Wedgwood, S., and Black, S.M. (2005 Endothelin-1 decreases endothelial NOS expression and activity through ETA receptormediated generation of hydrogen peroxide. Am J Physiol Lung Cell Mol Physiol 288, L480-L487.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288
    • Wedgwood, S.1    Black, S.M.2
  • 51
    • 0037377477 scopus 로고    scopus 로고
    • Developmental differences in the shear stress-induced expression of endothelial NO synthase: Changing role of AP-1
    • Wedgwood, S., Mitchell, C.J., Fineman, J.R., and Black, S.M. (2003) Developmental differences in the shear stress-induced expression of endothelial NO synthase: Changing role of AP-1. Am J Physiol Lung Cell Mol Physiol 284, L650-L662.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284
    • Wedgwood, S.1    Mitchell, C.J.2    Fineman, J.R.3    Black, S.M.4
  • 52
    • 0024498792 scopus 로고
    • Ligating the ductus arteriosus before birth remodels the pulmonary vasculature of the lamb
    • Wild, L.M., Nickerson, P.A., and Morin, F.C., 3rd. (1989) Ligating the ductus arteriosus before birth remodels the pulmonary vasculature of the lamb. Pediatr Res 25, 251-257.
    • (1989) Pediatr Res , vol.25 , pp. 251-257
    • Wild, L.M.1    Nickerson, P.A.2    Morin Iii, F.C.3
  • 53
    • 23744478764 scopus 로고    scopus 로고
    • Endothelin-1 concentrations in clone calves, their surrogate dams, and fetal fluids at birth: Association with oxygen treatment
    • Wilkins, P.A., Boston, R., Palmer, J.E., and Armstead, W.M. (2005) Endothelin-1 concentrations in clone calves, their surrogate dams, and fetal fluids at birth: Association with oxygen treatment. J Vet Intern Med 19, 594-598.
    • (2005) J Vet Intern Med , vol.19 , pp. 594-598
    • Wilkins, P.A.1    Boston, R.2    Palmer, J.E.3    Armstead, W.M.4
  • 55
    • 0027140804 scopus 로고
    • Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb
    • Wong, J., Vanderford, P.A., Fineman, J.R., Chang, R., and Soifer, S.J. (1993) Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb. Am J Physiol 265, H1318-H1325.
    • (1993) Am J Physiol , vol.265
    • Wong, J.1    Vanderford, P.A.2    Fineman, J.R.3    Chang, R.4    Soifer, S.J.5
  • 56
    • 0028059994 scopus 로고
    • Developmental effects of endothelin-1 on the pulmonary circulation in sheep
    • Wong, J., Vanderford, P.A., Fineman, J.R., and Soifer, S.J. (1994) Developmental effects of endothelin-1 on the pulmonary circulation in sheep. Pediatr Res 36, 394-401.
    • (1994) Pediatr Res , vol.36 , pp. 394-401
    • Wong, J.1    Vanderford, P.A.2    Fineman, J.R.3    Soifer, S.J.4
  • 57
    • 0027992642 scopus 로고
    • ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
    • Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., deWit, D., and Yanagisawa, M. (1994) ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 78, 473-485.
    • (1994) Cell , vol.78 , pp. 473-485
    • Xu, D.1    Emoto, N.2    Giaid, A.3    Slaughter, C.4    Kaw Dewit S, D.5    Yanagisawa, M.6
  • 58
    • 5344223386 scopus 로고    scopus 로고
    • Link between free radicals and protein kinase C in glucoseinduced alteration of vascular dilation
    • Yakubu, M.A., Sofola, O.A., Igbo, I., and Oyekan, A.O. (2004) Link between free radicals and protein kinase C in glucoseinduced alteration of vascular dilation. Life Sci 75, 2921-2932.
    • (2004) Life Sci , vol.75 , pp. 2921-2932
    • Yakubu, M.A.1    Sofola, O.A.2    Igbo, I.3    Oyekan, A.O.4
  • 59
    • 0036444317 scopus 로고    scopus 로고
    • Decreased expression of brain nitric oxide synthase in macula densa cells and glomerular epithelial cells of rats with mercury chloride-induced acute renal failure
    • Yanagisawa, H., Nodera, M., Sato, M., Moridaira, K., Sato, G., and Wada, O. (2002) Decreased expression of brain nitric oxide synthase in macula densa cells and glomerular epithelial cells of rats with mercury chloride-induced acute renal failure. Toxicol Appl Pharmacol 184, 165-171.
    • (2002) Toxicol Appl Pharmacol , vol.184 , pp. 165-171
    • Yanagisawa, H.1    Nodera, M.2    Sato, M.3    Moridaira, K.4    Sato, G.5    Wada, O.6
  • 60
    • 0028929453 scopus 로고
    • Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaquei A clue to the mechanism of increased vasoreactivity of the culprit lesion in unstable angina
    • Zeiher, A.M., Goebel, H., Schachinger, V., and Ihling, C. (1995 Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaque. A clue to the mechanism of increased vasoreactivity of the culprit lesion in unstable angina. Circulation 91, 941-947.
    • (1995) Circulation , vol.91 , pp. 941-947
    • Zeiher, A.M.1    Goebel, H.2    Schachinger, V.3    Ihling, C.4


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