Molecular analysis of cocaine-induced endothelial dysfunction: Role of endothelin-1 and nitric oxide

Cardiovascular Toxicology

Volumn 8, Issue 4, 2008, Pages 161-171

  Pradhan, Leena ^a,b   Mondal, Debasis ^a   Chandra, Surabhi ^a   Ali, Mussa ^a   Agrawal, Krishna C ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cocaine; Endothelial dysfunction; Endothelin receptors; Endothelin 1; HAECs; Leukocyte adhesion; Nitric oxide

Indexed keywords

COCAINE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; NITRIC OXIDE; ENDOTHELIN B RECEPTOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; NOS3 PROTEIN, HUMAN; PROTEIN PRECURSOR; UNCLASSIFIED DRUG; VASOCONSTRICTOR AGENT;

ARTICLE; CELL ACTIVATION; CELL ADHESION; CELL STRAIN U937; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; AORTA; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; GENETICS; LEUKOCYTE; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

AORTA; CELL ADHESION; CELLS, CULTURED; COCAINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; LEUKOCYTES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN PRECURSORS; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; U937 CELLS; VASOCONSTRICTOR AGENTS;

EID: 59649101405     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12012-008-9025-z     Document Type: Article

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