Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats

Phytotherapy Research

Volumn 23, Issue 11, 2009, Pages 1559-1564

  Zdunic G ^a   Godevac, D ^b   Milenkovic M ^c   Vucicevic D ^c   Savikin K ^a   Menkovic N ^a   Petrovic S ^c  

^a Institute for Medicinal Plant Research Dr Josif Pan i   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c Faculty of Pharmacy   (Serbia)

Author keywords

Antiinflammatory activity; Gastroprotective activity; Hypericum perforatum L.; I3,II8 biapigenin; Oleum Hyperici; Quercetin

Indexed keywords

CARRAGEENAN; HYPERICUM PERFORATUM EXTRACT; INDOMETACIN; QUERCETIN; SUNFLOWER OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BATH; CONTROLLED STUDY; HEATING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PAW EDEMA; RAT; STOMACH MUCOSA LESION; STOMACH PROTECTION; SUNFLOWER;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-ULCER AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYPERICUM; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR;

HELIANTHUS; HYPERICUM PERFORATUM; RATTUS;

EID: 70350439495     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2809     Document Type: Article

References (37)

1. Abdallah DM. 2004. Gastroprotective effect of L-arginine and quercetin in indomethacin-induced gastric lesions in rats. Egypt J Biomed Sci 15: 194-206.
2. Adami E, Marazzi-Uberti E, Turba C. 1964. Pharmacological research on gefarnate, a new synthetic isoprenoid with an anti-ulcer action. Arch Int Pharmacodyn Ther 147: 113-145.
3. Azuma K, Ippoushi K, Ito H, Higashio H, Terao J. 2002. Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. J Agric Food Chem 50: 1706-1712. (Pubitemid 34233251)
4. Bilia AR, Gallori S, Vincieri FF. 2002. St. John's wort and depression. Efficacy, safety and tolerability - an update. Life Sci 70: 3077-3096.
5. Blumenthal M (ed.). 1998. St John's wort. In The Complete German Commission E Monographs. American Botanical Council: Austin, CD-ROM.
6. DAB 6 (EB6). 1953. Supplement to Deutsches Arzneibuch. 6th edn. Deutscher Apotheker Verlag: Berlin.
7. ESCOP. 2003. Monographs on the Medicinal Uses of Plant Drugs. Hyperici herba. European Scientific Cooperative on Phytotherapy: Exeter, 257-281.
8. Graefe EU, Derendorf H, Veit M. 1999. Pharmacokinetics and bioavailability of the flavanol quercetin in humans. Int J Clin Pharmacol Ther 37: 219-233. (Pubitemid 29216610)
9. Hammer KDP, Hillwig ML, Solco AKS et al. 2007. Inhibition of prostaglandin E2 production by anti-inflammatory Hypericum perforatum extracts and constituents in RAW264.7 mouse macrophage cells. J Agric Food Chem 55: 7323-7331.
10. Isacchi B, Bergonzi MC, Carnevalli F, van der Esch SA, Vincieri FF, Bilia AR. 2007. Analysis and stability of the constituents of St John's wort oils prepared with different methods. J Pharm Biomed Anal 45: 756-761. (Pubitemid 350103652)
11. Lavagna SM, Secci D, Chimenti P, Bonsignore L, Ottaviani A, Bizzarri B. 2001. Efficacy of Hypericum and Calendula oils in the epithelial reconstruction of surgical wounds in childbirth with caesarean section. Farmaco 56: 451-453. (Pubitemid 32622116)
12. Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Melchart D. 1996. St. John's wort for depression: an overview and meta-analysis of randomised clinical trials. Br Med J 313: 253-258.
13. Maisenbacher P, Kovar KA. 1992. Analysis and stability of Hyperici oleum. Planta Med 58: 351-354.
14. Martin MJ, Motilva V, Alarcon de la Lastra, C. 1993. Quercetin and naringenin: efects on ulcer formation and gastric secretion in rats. Phytother Res 7: 150-153.
15. Min YD, Choi CH, Bark H et al. 2007. Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-κB and p38 MAPK in HMC-1 human mast cell line. Inflamm Res 56: 210-215. (Pubitemid 46985839)
16. Miraldi E, Biagi M, Giachetti D. 2006. Chemical constituents and effects of topical application of Oleum Hyperici on skin sensitivity to simulated sun exposure. Nat Prod Commun 1: 209-213.
17. Morikawa K, Nonako M, Narahara M et al. 2003. Inhibitory effects of quercetin on carrageenan-induced inflammation in rats. Life Sci 74: 709-721. (Pubitemid 37494898)
18. Moroney MA, Alcaraz MJ, Folder RA, Carey F, Hoult SRS. 1988. Selectivity of neutrophil 5-lipoxygenase and cycloxygenase inhibition by anti-inflammatory flavonoid glycoside and related aglycone flavonoids. J Pharm Pharmacol 40: 787-792. (Pubitemid 18274065)
19. Nair MP, Mahajan S, Reynolds JL et al. 2006. The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-κB system. Clin Vaccine Immunol 13: 319-328.
20. Oyanagui Y, Sato S. 1991. Inhibition by nilvadipine of ischemic and carrageenan paw edema as well as of superoxide radical production from neutrophils and xanthine oxidase. Arzneimittelforsch Drug Res 41: 5.
21. Öztürk N, Korkmaz S, Öztürk Y. 2007. Wound-healing activity of St. John's Wort ( Hypericum perforatum L.) on chicken embryonic fibroblasts. J Ethnopharmacol 11: 33-39. (Pubitemid 46482878)
22. Pahlow M. 1989. Great Book of Medicinal Plants (in Croatian). Cankarjeva založba: Zagreb.
23. Pelzer LE, Guardia T, Juarez TG, Guerreiro E. 1998. Acute and chronic antiinflammatory effects of plant flavonoids. Farmaco 53: 421-424. (Pubitemid 28408768)
24. Petrović SD, Dobrić S, Bokonjić D, Niketić M, Garcia-Pineres A, Merfort I. 2003. Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats. J Ethnopharmacol 87: 109-113. (Pubitemid 36644982)
25. Rao SG, Udupa SL, Rao PGM, Rao G, Kulkurni DR. 1991. Calendula and Hypericum: two homeopathic drugs promoting wound healing in rats. Fitoterapia 6: 508-510.
26. Robson NKB. 1968. Hypericum L. In Flora Europaea, Webb DA (ed.). Cambridge University Press: London, 261-269.
27. Šavikin K, Dobrić S, Tadić V, Zdunić G. 2007. Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats. Phytother Res 21: 176-180. (Pubitemid 46255084)
28. Šikov AN, Makarov VG, Rizenkov VE. 2004. Vegetable oils and oil extracts: technology, standardization, characteristics (in Russian). Ruskii vraš: Moscow.
29. Stjepanović-Veselčić L. 1972. Hypericaceae. In Flora of Serbia III, Josifović M (ed.). SANU: Belgrade, 104-125.
30. Suzuki Y, Ishihara M, Segami T, Ito M. 1998. Anti-ulcer effects of antioxidants, quercetin, α-tocopherol, nifedipine and tetracycline in rats. Jpn J Pharmacol 78: 435-441. (Pubitemid 29052065)
31. Tucakov J. 1996. Healing by Plants (in Serbian). Rad: Belgrade.
32. Uzbay TI. 2008. Hypericum peforatum and substance dependence: A review. Phytother Res 22: 578-582.
33. Weiss RF, Fintelmann V. 2000. Herbal Medicines. Georg Thieme Verlag: Stuttgart.
34. WHO. 2002. Monographs on Selected Medicinal Plants, vol 2. Herba Hyperici. World Health Organization: Geneva, 149-171.
35. Woo E, Pokharel YR, Yang JW, Lee SY, Kang KW. 2006. Inhibition of nuclear factor-κB activation by 2′,8″-biapigenin. Biol Pharm Bull 29: 976-980.
36. Yesilada E, Gürbüz I, Shibata H. 1999. Screening of Turkish anti-ulcerogenic folk remedies for anti- Helicobacter pylori activity. J Ethnopharmacol 66: 289-293. (Pubitemid 29287197)
37. Zdunić G, GoCrossed d sign;evac D, Šavikin K, Milosavljević S, Petrović S. 2006. Flavonoid composition and antioxidant capacity of Hypericum richeri Vill. In Book of Abstracts. International Symposium on Organic Chemistry: Sofia, 65.