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Volumn 276, Issue 22, 2009, Pages 6548-6559

Epitope analysis of the rat dipeptidyl peptidase IV monoclonal antibody 6A3 that blocks pericellular fibronectin-mediated cancer cell adhesion

Author keywords

Dipeptidyl peptidase IV; Epitope mapping; Monoclonal antibody; Polymeric fibronectin; Steric hindrance

Indexed keywords

AMINO ACID; DIPEPTIDYL PEPTIDASE IV; FIBRONECTIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 6A3; PARAFORMALDEHYDE; UNCLASSIFIED DRUG;

EID: 70350437711     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07352.x     Document Type: Article
Times cited : (9)

References (37)
  • 1
    • 0043092068 scopus 로고    scopus 로고
    • A novel consensus motif in fibronectin mediates dipeptidyl peptidase IV adhesion and metastasis
    • Cheng HC, Abdel-Ghany M Pauli BU (2003) A novel consensus motif in fibronectin mediates dipeptidyl peptidase IV adhesion and metastasis. J Biol Chem 278, 24600 24607.
    • (2003) J Biol Chem , vol.278 , pp. 24600-24607
    • Cheng, H.C.1    Abdel-Ghany, M.2    Pauli, B.U.3
  • 2
    • 0027221739 scopus 로고
    • Lung endothelial dipeptidyl peptidase IV is an adhesion molecule for lung-metastatic rat breast and prostate carcinoma cells
    • Johnson RC, Zhu D, Augustin-Voss HG Pauli BU (1993) Lung endothelial dipeptidyl peptidase IV is an adhesion molecule for lung-metastatic rat breast and prostate carcinoma cells. J Cell Biol 121, 1423 1432.
    • (1993) J Cell Biol , vol.121 , pp. 1423-1432
    • Johnson, R.C.1    Zhu, D.2    Augustin-Voss, H.G.3    Pauli, B.U.4
  • 3
    • 0032508633 scopus 로고    scopus 로고
    • Lung endothelial dipeptidyl peptidase IV promotes adhesion and metastasis of rat breast cancer cells via tumor cell surface-associated fibronectin
    • DOI 10.1074/jbc.273.37.24207
    • Cheng HC, Abdel-Ghany M, Elble RC Pauli BU (1998) Lung endothelial dipeptidyl peptidase IV promotes adhesion and metastasis of rat breast cancer cells via tumor cell surface-associated fibronectin. J Biol Chem 273, 24207 24215. (Pubitemid 28435768)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.37 , pp. 24207-24215
    • Cheng, H.-C.1    Abdel-Ghany, M.2    Elble, R.C.3    Pauli, B.U.4
  • 4
    • 0033499058 scopus 로고    scopus 로고
    • Is the Fischer 344/CRJ rat a protein-knock-out model for dipeptidyl peptidase IV-mediated lung metastasis of breast cancer?
    • Cheng HC, Abdel-Ghany M, Zhang S Pauli BU (1999) Is the Fischer 344/CRJ rat a protein-knock-out model for dipeptidyl peptidase IV-mediated lung metastasis of breast cancer? Clin Exp Metastasis 17, 609 615.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 609-615
    • Cheng, H.C.1    Abdel-Ghany, M.2    Zhang, S.3    Pauli, B.U.4
  • 5
    • 43149096710 scopus 로고    scopus 로고
    • Protein kinase Cepsilon mediates polymeric fibronectin assembly on the surface of blood-borne rat breast cancer cells to promote pulmonary metastasis
    • Huang L, Cheng HC, Isom R, Chen CS, Levine RA Pauli BU (2008) Protein kinase Cepsilon mediates polymeric fibronectin assembly on the surface of blood-borne rat breast cancer cells to promote pulmonary metastasis. J Biol Chem 283, 7616 7627.
    • (2008) J Biol Chem , vol.283 , pp. 7616-7627
    • Huang, L.1    Cheng, H.C.2    Isom, R.3    Chen, C.S.4    Levine, R.A.5    Pauli, B.U.6
  • 6
    • 0035723325 scopus 로고    scopus 로고
    • CD26: A multifunctional integral membrane and secreted protein of activated lymphocytes
    • Gorrell MD, Gysbers V McCaughan GW (2001) CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes. Scand J Immunol 54, 249 264.
    • (2001) Scand J Immunol , vol.54 , pp. 249-264
    • Gorrell, M.D.1    Gysbers, V.2    McCaughan, G.W.3
  • 7
    • 0037928769 scopus 로고    scopus 로고
    • The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: In vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38)
    • Zhu L, Tamvakopoulos C, Xie D, Dragovic J, Shen X, Fenyk-Melody JE, Schmidt K, Bagchi A, Griffin PR, Thornberry NA et al. (2003) The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38). J Biol Chem 278, 22418 22423.
    • (2003) J Biol Chem , vol.278 , pp. 22418-22423
    • Zhu, L.1    Tamvakopoulos, C.2    Xie, D.3    Dragovic, J.4    Shen, X.5    Fenyk-Melody, J.E.6    Schmidt, K.7    Bagchi, A.8    Griffin, P.R.9    Thornberry, N.A.10
  • 9
    • 46749153785 scopus 로고    scopus 로고
    • From the bench to the bedside: Dipeptidyl peptidase IV inhibitors, a new class of oral antihyperglycemic agents
    • Pei Z (2008) From the bench to the bedside: dipeptidyl peptidase IV inhibitors, a new class of oral antihyperglycemic agents. Curr Opin Drug Discov Devel 11, 512 532.
    • (2008) Curr Opin Drug Discov Devel , vol.11 , pp. 512-532
    • Pei, Z.1
  • 11
    • 28844459379 scopus 로고    scopus 로고
    • Fibronectin fibrillogenesis, a cell-mediated matrix assembly process
    • Mao Y Schwarzbauer JE (2005) Fibronectin fibrillogenesis, a cell-mediated matrix assembly process. Matrix Biol 24, 389 399.
    • (2005) Matrix Biol , vol.24 , pp. 389-399
    • Mao, Y.1    Schwarzbauer, J.E.2
  • 12
    • 0042887252 scopus 로고    scopus 로고
    • The ins and outs of fibronectin matrix assembly
    • Wierzbicka-Patynowski I Schwarzbauer JE (2003) The ins and outs of fibronectin matrix assembly. J Cell Sci 116, 3269 3276.
    • (2003) J Cell Sci , vol.116 , pp. 3269-3276
    • Wierzbicka-Patynowski, I.1    Schwarzbauer, J.E.2
  • 13
    • 33745206673 scopus 로고    scopus 로고
    • Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27(kip1) enhancement, and disruption of binding to the extracellular matrix
    • Inamoto T, Yamochi T, Ohnuma K, Iwata S, Kina S, Inamoto S, Tachibana M, Katsuoka Y, Dang NH Morimoto C (2006) Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27(kip1) enhancement, and disruption of binding to the extracellular matrix. Clin Cancer Res 12, 3470 3477.
    • (2006) Clin Cancer Res , vol.12 , pp. 3470-3477
    • Inamoto, T.1    Yamochi, T.2    Ohnuma, K.3    Iwata, S.4    Kina, S.5    Inamoto, S.6    Tachibana, M.7    Katsuoka, Y.8    Dang, N.H.9    Morimoto, C.10
  • 16
    • 34250352437 scopus 로고    scopus 로고
    • Cell adhesion and cancer: Is there a potential for therapeutic intervention?
    • Lafrenie RM, Buckner CA Bewick MA (2007) Cell adhesion and cancer: is there a potential for therapeutic intervention? Expert Opin Ther Targets 11, 727 731.
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 727-731
    • Lafrenie, R.M.1    Buckner, C.A.2    Bewick, M.A.3
  • 17
    • 21644478072 scopus 로고    scopus 로고
    • Anti-adhesion therapies
    • Simmons DL (2005) Anti-adhesion therapies. Curr Opin Pharmacol 5, 398 404.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 398-404
    • Simmons, D.L.1
  • 18
    • 42649087085 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes
    • Flatt PR, Bailey CJ Green BD (2008) Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes. Front Biosci 13, 3648 3660.
    • (2008) Front Biosci , vol.13 , pp. 3648-3660
    • Flatt, P.R.1    Bailey, C.J.2    Green, B.D.3
  • 19
    • 20144365757 scopus 로고    scopus 로고
    • Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: Enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators
    • Matsoukas J, Apostolopoulos V, Kalbacher H, Papini AM, Tselios T, Chatzantoni K, Biagioli T, Lolli F, Deraos S, Papathanassopoulos P et al. (2005) Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators. J Med Chem 48, 1470 1480.
    • (2005) J Med Chem , vol.48 , pp. 1470-1480
    • Matsoukas, J.1    Apostolopoulos, V.2    Kalbacher, H.3    Papini, A.M.4    Tselios, T.5    Chatzantoni, K.6    Biagioli, T.7    Lolli, F.8    Deraos, S.9    Papathanassopoulos, P.10
  • 21
    • 21144433924 scopus 로고    scopus 로고
    • Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature
    • May C, Doody JF, Abdullah R, Balderes P, Xu X, Chen CP, Zhu Z, Shapiro L, Kussie P, Hicklin DJ et al. (2005) Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature. Blood 105, 4337 4344.
    • (2005) Blood , vol.105 , pp. 4337-4344
    • May, C.1    Doody, J.F.2    Abdullah, R.3    Balderes, P.4    Xu, X.5    Chen, C.P.6    Zhu, Z.7    Shapiro, L.8    Kussie, P.9    Hicklin, D.J.10
  • 24
    • 17144404555 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders
    • Gorrell MD (2005) Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders. Clin Sci (Lond) 108, 277 292.
    • (2005) Clin Sci (Lond) , vol.108 , pp. 277-292
    • Gorrell, M.D.1
  • 25
    • 0028830219 scopus 로고
    • A modified pGEX expression system that eliminates degradation products and thrombin from the recombinant protein
    • Sun G Budde RJ (1995) A modified pGEX expression system that eliminates degradation products and thrombin from the recombinant protein. Anal Biochem 231, 458 460.
    • (1995) Anal Biochem , vol.231 , pp. 458-460
    • Sun, G.1    Budde, R.J.2
  • 26
    • 0027499695 scopus 로고
    • Fixation for the 1990's: A review of needs and accomplishments
    • Dapson RW (1993) Fixation for the 1990's: a review of needs and accomplishments. Biotech Histochem 68, 75 82.
    • (1993) Biotech Histochem , vol.68 , pp. 75-82
    • Dapson, R.W.1
  • 27
    • 34247876138 scopus 로고    scopus 로고
    • Development trends for monoclonal antibody cancer therapeutics
    • Reichert JM Valge-Archer VE (2007) Development trends for monoclonal antibody cancer therapeutics. Nat Rev Drug Discov 6, 349 356.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 349-356
    • Reichert, J.M.1    Valge-Archer, V.E.2
  • 30
    • 0034472912 scopus 로고    scopus 로고
    • Relating structure to function in the beta-propeller domain of dipeptidyl peptidase IV. Point mutations that influence adenosine deaminase binding, antibody binding and enzyme activity
    • Gorrell MD, Abbott CA, Kahne T, Levy MT, Church WB McCaughan GW (2000) Relating structure to function in the beta-propeller domain of dipeptidyl peptidase IV. Point mutations that influence adenosine deaminase binding, antibody binding and enzyme activity. Adv Exp Med Biol 477, 89 95.
    • (2000) Adv Exp Med Biol , vol.477 , pp. 89-95
    • Gorrell, M.D.1    Abbott, C.A.2    Kahne, T.3    Levy, M.T.4    Church, W.B.5    McCaughan, G.W.6
  • 31
    • 40049108020 scopus 로고    scopus 로고
    • Changes in blood ROS, e-NO, and some pro-inflammatory mediators in bronchial secretions following erdosteine or placebo: A controlled study in current smokers with mild COPD
    • Dal Negro RW, Visconti M, Micheletto C Tognella S (2008) Changes in blood ROS, e-NO, and some pro-inflammatory mediators in bronchial secretions following erdosteine or placebo: a controlled study in current smokers with mild COPD. Pulm Pharmacol Ther 21, 304 308.
    • (2008) Pulm Pharmacol Ther , vol.21 , pp. 304-308
    • Dal Negro, R.W.1    Visconti, M.2    Micheletto, C.3    Tognella, S.4
  • 33
    • 33749045289 scopus 로고    scopus 로고
    • Mechanisms of disease: Oxidative stress and inflammation in the pathogenesis of hypertension
    • Vaziri ND Rodriguez-Iturbe B (2006) Mechanisms of disease: oxidative stress and inflammation in the pathogenesis of hypertension. Nat Clin Pract Nephrol 2, 582 593.
    • (2006) Nat Clin Pract Nephrol , vol.2 , pp. 582-593
    • Vaziri, N.D.1    Rodriguez-Iturbe, B.2
  • 34
    • 42549085269 scopus 로고    scopus 로고
    • NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype
    • Dworakowski R, Alom-Ruiz SP Shah AM (2008) NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype. Pharmacol Rep 60, 21 28.
    • (2008) Pharmacol Rep , vol.60 , pp. 21-28
    • Dworakowski, R.1    Alom-Ruiz, S.P.2    Shah, A.M.3
  • 35
    • 0345390964 scopus 로고    scopus 로고
    • Truncated dipeptidyl peptidase IV is a potent anti-adhesion and anti-metastasis peptide for rat breast cancer cells
    • Abdel-Ghany M, Cheng H, Levine RA Pauli BU (1998) Truncated dipeptidyl peptidase IV is a potent anti-adhesion and anti-metastasis peptide for rat breast cancer cells. Invasion Metastasis 18, 35 43.
    • (1998) Invasion Metastasis , vol.18 , pp. 35-43
    • Abdel-Ghany, M.1    Cheng, H.2    Levine, R.A.3    Pauli, B.U.4
  • 36
    • 1542676834 scopus 로고    scopus 로고
    • The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis
    • Abdel-Ghany M, Cheng HC, Elble RC, Lin H, DiBiasio J Pauli BU (2003) The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis. J Biol Chem 278, 49406 49416.
    • (2003) J Biol Chem , vol.278 , pp. 49406-49416
    • Abdel-Ghany, M.1    Cheng, H.C.2    Elble, R.C.3    Lin, H.4    Dibiasio, J.5    Pauli, B.U.6
  • 37
    • 0028069348 scopus 로고
    • Superfibronectin is a functionally distinct form of fibronectin
    • Morla A, Zhang Z Ruoslahti E (1994) Superfibronectin is a functionally distinct form of fibronectin. Nature 367, 193 196.
    • (1994) Nature , vol.367 , pp. 193-196
    • Morla, A.1    Zhang, Z.2    Ruoslahti, E.3


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