CD46 transgenic mouse model of necrotizing fasciitis caused by Streptococcus pyogenes infection

Infection and Immunity

Volumn 77, Issue 11, 2009, Pages 4806-4814

  Matsui, Hidenori ^a   Sekiya, Yukie ^a   Nakamura, Masahiko ^a   Murayama, Somay Yamagata ^a   Yoshida, Haruno ^a   Takahashi, Tetsufumi ^a   Imanishi, Ken'ichi ^b   Tsuchimoto, Kanji ^a   Uchiyama, Takehiko ^b,c   Sunakawa, Keisuke ^a   Ubukata, Kimiko ^a  

^a KITASATO UNIVERSITY   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c TOKIWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE COFACTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; EPIDERMIS; FOOT; GROUP A STREPTOCOCCAL INFECTION; LIVER INJURY; MORTALITY; MOUSE; NECROTIZING FASCIITIS; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; STRAIN DIFFERENCE; STREPTOCOCCUS PYOGENES;

ANIMALS; ANTIGENS, CD46; DISEASE MODELS, ANIMAL; FASCIITIS, NECROTIZING; HUMANS; MICE; MICE, TRANSGENIC; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES;

EID: 70350435128     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00577-09     Document Type: Article

References (48)

1. Ashbaugh, C. D., H. B. Warren, V. J. Carey, and M. R. Wessels. 1998. Molecular analysis of the role of the group A streptococcal cysteine protease, hyaluronic acid capsule, and M protein in a murine model of human invasive soft-tissue infection. J. Clin. Investig. 102:550-560.
2. Ato, M., T. Ikebe, H. Kawabata, T. Takemori, and H. Watanabe. 2008. Incompetence of neutrophils to invasive group A streptococcus is attributed to induction of plural virulence factors by dysfunction of a regulator. PLoS ONE 3:e3455.
3. Aziz, R. K., and M. Kotb. 2008. Rise and persistence of global M1T1 clone of Streptococcus pyogenes. Emerg. Infect. Dis. 14:1511-1517.
4. Bisno, A. L., and D. L. Stevens. 1996. Streptococcal infections of skin and soft tissues. N. Engl. J. Med. 334:240-245.
5. Brenot, A., K. Y. King, B. Janowiak, O. Griffith, and M. G. Caparon. 2004. Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes. Infect. Immun. 72:408-413.
6. Dalton, T. L., R. I. Hobb, and J. R. Scott. 2006. Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease. Microb. Pathog. 40:221-227.
7. Datta, V., S. M. Myskowski, L. A. Kwinn, D. N. Chiem, N. Varki, R. G. Kansal, M. Kotb, and V. Nizet. 2005. Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection. Mol. Microbiol. 56:681-695.
8. Di Nardo, A., K. Yamasaki, R. A. Dorschner, Y. Lai, and R. L. Gallo. 2008. Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin. J. Immunol. 180:7565-7573.
9. Dorig, R. E., A. Marcil, A. Chopra, and C. D. Richardson. 1993. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75:295-305. (Pubitemid 23320293)
10. Edwards, R. J., G. W. Taylor, M. Ferguson, S. Murray, N. Rendell, A. Wrigley, Z. Bai, J. Boyle, S. J. Finney, A. Jones, H. H. Russell, C. Turner, J. Cohen, L. Faulkner, and S. Sriskandan. 2005. Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes. J. Infect. Dis. 192:783-790.
11. Eguchi, M., Y. Sekiya, M. Suzuki, T. Yamamoto, and H. Matsui. 2007. An oral Salmonella vaccine promotes the down-regulation of cell surface Toll-like receptor 4 (TLR4) and TLR2 expression in mice. FEMS Immunol. Med. Microbiol. 50:300-308.
12. Feito, M. J., A. Sanchez, M. A. Oliver, D. Perez-Caballero, S. Rodriguez de Cordoba, S. Alberti, and J. M. Rojo. 2007. Membrane cofactor protein (MCP, CD46) binding to clinical isolates of Streptococcus pyogenes: binding to M type 18 strains is independent of Emm or Enn proteins. Mol. Immunol. 44:3571-3579.
13. Filbin, M. R., D. C. Ring, M. R. Wessels, L. L. Avery, and R. L. Kradin. 2009. Case records of the Massachusetts General Hospital. Case 2-2009. A 25-year-old man with pain and swelling of the right hand and hypotension. N. Engl. J. Med. 360:281-290.
14. Fischetti, V. A. 1989. Streptococcal M protein: molecular design and biological behavior. Clin. Microbiol. Rev. 2:285-314.
15. Fischetti, V. A., K. F. Jones, S. K. Hollingshead, and J. R. Scott. 1988. Structure, function, and genetics of streptococcalMprotein. Rev. Infect. Dis. 10(Suppl. 2):S356-S359.
16. Fustes-Morales, A., P. Gutierrez-Castrellon, C. Duran-Mckinster, L. Orozco-Covarrubias, L. Tamayo-Sanchez, and R. Ruiz-Maldonado. 2002. Necrotizing fasciitis: report of 39 pediatric cases. Arch. Dermatol. 138:893-899.
17. Gaggar, A., D. M. Shayakhmetov, and A. Lieber. 2003. CD46 is a cellular receptor for group B adenoviruses. Nat. Med. 9:1408-1412.
18. Graham, M. R., L. M. Smoot, C. A. Migliaccio, K. Virtaneva, D. E. Sturdevant, S. F. Porcella, M. J. Federle, G. J. Adams, J. R. Scott, and J. M. Musser. 2002. Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling. Proc. Natl. Acad. Sci. USA 99:13855-13860.
19. Herwald, H., H. Cramer, M. Morgelin, W. Russell, U. Sollenberg, A. Norrby-Teglund, H. Flodgaard, L. Lindbom, and L. Bjorck. 2004. M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage. Cell 116:367-379. (Pubitemid 38366314)
20. Hidalgo-Grass, C., M. Dan-Goor, A. Maly, Y. Eran, L. A. Kwinn, V. Nizet, M. Ravins, J. Jaffe, A. Peyser, A. E. Moses, and E. Hanski. 2004. Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections. Lancet 363:696-703. (Pubitemid 38296556)
21. Johansson, L., A. Rytkonen, P. Bergman, B. Albiger, H. Kallstrom, T. Hokfelt, B. Agerberth, R. Cattaneo, and A. B. Jonsson. 2003. CD46 in meningococcal disease. Science 301:373-375.
22. Johansson, L., A. Rytkonen, H. Wan, P. Bergman, L. Plant, B. Agerberth, T. Hokfelt, and A. B. Jonsson. 2005. Human-like immune responses in CD46 transgenic mice. J. Immunol. 175:433-440. (Pubitemid 40884347)
23. Kallstrom, H., M. K. Liszewski, J. P. Atkinson, and A. B. Jonsson. 1997. Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. Mol. Microbiol. 25:639-647. (Pubitemid 27394562)
24. Kansal, R. G., A. McGeer, D. E. Low, A. Norrby-Teglund, and M. Kotb. 2000. Inverse relation between disease severity and expression of the streptococcal cysteine protease, SpeB, among clonal M1T1 isolates recovered from invasive group A streptococcal infection cases. Infect. Immun. 68:6362-6369.
25. Kemper, C., M. Leung, C. B. Stephensen, C. A. Pinkert, M. K. Liszewski, R. Cattaneo, and J. P. Atkinson. 2001. Membrane cofactor protein (MCP; CD46) expression in transgenic mice. Clin. Exp. Immunol. 124:180-189.
26. Kemper, C., J. W. Verbsky, J. D. Price, and J. P. Atkinson. 2005. T-cell stimulation and regulation: with complements from CD46. Immunol. Res. 32:31-43.
27. Kodama, C., M. Eguchi, Y. Sekiya, T. Yamamoto, Y. Kikuchi, and H. Matsui. 2005. Evaluation of the Lon-deficient Salmonella strain as an oral vaccine candidate. Microbiol. Immunol. 49:1035-1045.
28. Leitch, H. A., A. Palepu, and C. M. Fernandes. 2000. Necrotizing fasciitis secondary to group A streptococcus. Morbidity and mortality still high. Can. Fam. Physician 46:1460-1466.
29. Liszewski, M. K., T. W. Post, and J. P. Atkinson. 1991. Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu. Rev. Immunol. 9:431-455.
30. Lövkvist, L., H. Sjölinder, R. Wehelie, H. Aro, A. Norrby-Teglund, L. Plant, and A.-B. Jonsson. 2008. CD46 contributes to the severity of group A streptococcal infection. Infect. Immun. 76:3951-3958.
31. Manchester, M., M. K. Liszewski, J. P. Atkinson, and M. B. Oldstone. 1994. Multiple isoforms of CD46 (membrane cofactor protein) serve as receptors for measles virus. Proc. Natl. Acad. Sci. USA 91:2161-2165.
32. Medina, E., O. Goldmann, A. W. Toppel, and G. S. Chhatwal. 2003. Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion. J. Infect. Dis. 187:597-603.
33. Miyoshi-Akiyama, T., J. Zhao, K. Kikuchi, H. Kato, R. Suzuki, M. Endoh, and T. Uchiyama. 2003. Quantitative and qualitative comparison of virulence traits, including murine lethality, among different M types of group A streptococci. J. Infect. Dis. 187:1876-1887.
34. Mrkic, B., J. Pavlovic, T. Rülicke, P. Volpe, C. J. Buchholz, D. Hourcade, J. P. Atkinson, A. Aguzzi, and R. Cattaneo. 1998. Measles virus spread and pathogenesis in genetically modified mice. J. Virol. 72:7420-7427. (Pubitemid 28377873)
35. Naniche, D., G. Varior-Krishnan, F. Cervoni, T. F. Wild, B. Rossi, C. Rabourdin-Combe, and D. Gerlier. 1993. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J. Virol. 67:6025-6032. (Pubitemid 23277513)
36. Nizet, V., T. Ohtake, X. Lauth, J. Trowbridge, J. Rudisill, R. A. Dorschner, V. Pestonjamasp, J. Piraino, K. Huttner, and R. L. Gallo. 2001. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414:454-457. (Pubitemid 34173727)
37. Okada, N., M. K. Liszewski, J. P. Atkinson, and M. Caparon. 1995. Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc. Natl. Acad. Sci. USA 92:2489-2493.
38. Peyssonnaux, C., A. S. Zinkernagel, V. Datta, X. Lauth, R. S. Johnson, and V. Nizet. 2006. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 107:3727-3732.
39. Rezcallah, M. S., K. Hodges, D. B. Gill, J. P. Atkinson, B. Wang, and P. P. Cleary. 2005. Engagement of CD46 and α5β1 integrin by group A streptococci is required for efficient invasion of epithelial cells. Cell. Microbiol. 7:645-653.
40. Santoro, F., P. E. Kennedy, G. Locatelli, M. S. Malnati, E. A. Berger, and P. Lusso. 1999. CD46 is a cellular receptor for human herpesvirus 6. Cell 99:817-827. (Pubitemid 30017651)
41. Segerman, A., J. P. Atkinson, M. Marttila, V. Dennerquist, G. Wadell, and N. Arnberg. 2003. Adenovirus type 11 uses CD46 as a cellular receptor. J. Virol. 77:9183-9191. (Pubitemid 37011015)
42. Sjolinder, H., and A. B. Jonsson. 2007. Imaging of disease dynamics during meningococcal sepsis. PLoS ONE 2:e241.
43. Sjölinder, H., L. Lövkvist, L. Plant, J. Eriksson, H. Aro, A. Jones, and A.-B. Jonsson. 2008. The ScpC protease of Streptococcus pyogenes affects the outcome of sepsis in a murine model. Infect. Immun. 76:3959-3966.
44. Stefanini, M., C. De Martino, and L. Zamboni. 1967. Fixation of ejaculated spermatozoa for electron microscopy. Nature 216:173-174.
45. Sumby, P., A. R. Whitney, E. A. Graviss, F. R. DeLeo, and J. M. Musser. 2006. Genome-wide analysis of group A streptococci reveals a mutation that modulates global phenotype and disease specificity. PLoS Pathog. 2:e5.
46. Tewodros, W., and G. Kronvall. 2005. M protein gene (emm type) analysis of group A beta-hemolytic streptococci from Ethiopia reveals unique patterns. J. Clin. Microbiol. 43:4369-4376.
47. Walker, M. J., A. Hollands, M. L. Sanderson-Smith, J. N. Cole, J. K. Kirk, A. Henningham, J. D. McArthur, K. Dinkla, R. K. Aziz, R. G. Kansal, A. J. Simpson, J. T. Buchanan, G. S. Chhatwal, M. Kotb, and V. Nizet. 2007. DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. Nat. Med. 13:981-985.
48. Wu, E., S. A. Trauger, L. Pache, T.-M. Mullen, D. J. von Seggern, G. Siuzdak, and G. R. Nemerow. 2004. Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis. J. Virol. 78: 3897-3905. (Pubitemid 38437196)