Immunoneutralization of agmatine sensitizes mice to μ-opioid receptor tolerance

Journal of Pharmacology and Experimental Therapeutics

Volumn 331, Issue 2, 2009, Pages 539-546

  Wade, Carrie L ^a   Eskridge, Lori L ^a   Nguyen, H Oanh X ^a   Kitto, Kelley F ^a   Stone, Laura S ^b,c   Wilcox, George ^a   Fairbanks, Carolyn A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AGMATINE; AGMATINE IMMUNOGLOBULIN G; ENDOMORPHIN 2; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; IMMUNOGLOBULIN G ANTIBODY; MU OPIATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG SENSITIVITY; DRUG TOLERANCE; EVOKED RESPONSE; IMMUNOMODULATION; IMMUNOREACTIVITY; IN VIVO STUDY; LOW DRUG DOSE; MALE; MOUSE; NERVE CELL PLASTICITY; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINE;

AGMATINE; ANALGESICS, OPIOID; ANIMALS; ANTIBODIES, BLOCKING; ARGININE; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; EXCITATORY AMINO ACID AGONISTS; GUINEA PIGS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; INJECTIONS, SPINAL; MALE; MICE; N-METHYLASPARTATE; OLIGOPEPTIDES; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; SPINAL CORD;

EID: 70350434124     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.155424     Document Type: Article

References (40)

1. Demady DR, Jianmongkol S, Vuletich JL, Bender AT, and Osawa Y (2001) Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme. Mol Pharmacol 59:24-29. (Pubitemid 32043081)
2. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, and Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946-1949. (Pubitemid 23026736)
3. Fairbanks CA, Schreiber KL, Brewer KL, Yu CG, Stone LS, Kitto KF, Nguyen HO, Grocholski BM, Shoeman DW, Kehl LJ, et al. (2000) Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury. Proc Natl Acad Sci U S A 97:10584-10589.
4. Fairbanks CA and Wilcox GL (1997) Acute tolerance to spinally administered morphine compares mechanistically with chronically induced morphine tolerance. J Pharmacol Exp Ther 282:1408-1417.
5. Gibson DA, Harris BR, Rogers DT, and Littleton JM (2002) Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil. Brain Res 952:71-77.
6. Goracke-Postle CJ, Nguyen HO, Stone LS, and Fairbanks CA (2006) Release of tritiated agmatine from spinal synaptosomes. Neuroreport 17:13-17.
7. Goracke-Postle CJ, Overland AC, Riedl MS, Stone LS, and Fairbanks CA (2007a) Potassium- and capsaicin-induced release of agmatine from spinal nerve terminals. J Neurochem 102:1738-1748. (Pubitemid 47329251)
8. Goracke-Postle CJ, Overland AC, Stone LS, and Fairbanks CA (2007b) Agmatine transport into spinal nerve terminals is modulated by polyamine analogs. J Neurochem 100:132-141. (Pubitemid 46085844)
9. Feng Y, LeBlanc MH, and Regunathan S (2005) Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects. Neurosci Lett 390:129-133. (Pubitemid 41483608)
10. Galea E, Regunathan S, Eliopoulos V, Feinstein DL, and Reis DJ (1996) Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochem J 316:247-249. (Pubitemid 126732849)
11. Gilad GM and Gilad VH (2000) Accelerated functional recovery and neuroprotection by agmatine after spinal cord ischemia in rats. Neurosci Lett 296:97-100.
12. Guerrero-Munoz F, de Lourdes Guerrero M, Way EL, and Li CH (1979) Effect of beta-endorphin on calcium uptake in the brain. Science 206:89-91. (Pubitemid 10244237)
13. Hardy SG and Haigler HJ (1985) Prefrontal influences upon the midbrain: a possible route for pain modulation. Brain Res 339:285-293.
14. Hylden JL and Wilcox GL (1980) Intrathecal morphine in mice: a new technique. Eur J Pharmacol 67:313-316. (Pubitemid 10007057)
15. Kolesnikov Y, Jain S, and Pasternak GW (1996) Modulation of opioid analgesia by agmatine. Eur J Pharmacol 296:17-22.
16. Lake JR, Hammond MV, Shaddox RC, Hunsicker LM, Yang HY, and Malin DH (1991) IgG from neuropeptide FF antiserum reverses morphine tolerance in the rat. Neurosci Lett 132:29-32.
17. Li G, Regunathan S, Barrow CJ, Eshraghi J, Cooper R, and Reis DJ (1994) Agmatine: an endogenous clonidine-displacing substance in the brain. Science 263:966-969. (Pubitemid 24094560)
18. Morgan AD, Campbell UC, Fons RD, and Carroll ME (2002) Effects of agmatine on the escalation of intravenous cocaine and fentanyl self-administration in rats. Pharmacol Biochem Behav 72:873-880. (Pubitemid 34621314)
19. Mulder AH, Wardeh G, Hogenboom F, and Frankhuyzen AL (1984) κ- and δ-Opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release. Nature 308:278-280. (Pubitemid 14132032)
20. Nguyen HO, Goracke-Postle CJ, Kaminski LL, Overland AO, Morgan AD, and Fairbanks CA (2003) Neuropharmacokinetic and dynamic studies of agmatine. Ann N Y Acad Sci 1009:82-105.
21. Ohsawa M, Mizoguchi H, Narita M, Nagase H, Kampine JP, and Tseng LF (2001) Differential antinociception induced by spinally administered endomorphin-1 and endomorphin-2 in the mouse. J Pharmacol Exp Ther 298:592-597. (Pubitemid 32673409)
22. Ossipov MH, Kovelowski CJ, Wheeler-Aceto H, Cowan A, Hunter JC, Lai J, Malan TP Jr, and Porreca F (1996) Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone. J Pharmacol Exp Ther 277:784-788. (Pubitemid 27168989)
23. Otake K, Ruggiero DA, Regunathan S, Wang H, Milner TA, and Reis DJ (1998) Regional localization of agmatine in the rat brain: an immunocytochemical study. Brain Res 787:1-14. (Pubitemid 28279794)
24. Pinthong D, Wright IK, Hanmer C, Millns P, Mason R, Kendall DA, and Wilson VG (1995) Agmatine recognizes alpha 2-adrenoceptor binding sites but neither activates nor inhibits alpha 2-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol 351:10-16.
25. Regunathan S, Feinstein DL, Raasch W, and Reis DJ (1995) Agmatine (decarboxylated arginine) is synthesized and stored in astrocytes. Neuroreport 6:1897-1900.
26. Reis DJ and Regunathan S (1998) Agmatine: a novel neurotransmitter? Adv Pharmacol 42:645-649.
27. Reynolds IJ (1990) Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptor. J Pharmacol Exp Ther 255:1001-1007.
28. Roberts JC, Grocholski BM, Kitto KF, and Fairbanks CA (2005) Pharmacodynamic and pharmacokinetic studies of agmatine after spinal administration in the mouse. J Pharmacol Exp Ther 314:1226-1233.
29. Sastre M, Regunathan S, Galea E, and Reis DJ (1996) Agmatinase activity in rat brain - a metabolic pathway for the degradation of agmatine. J Neurochem 67:1761-1765. (Pubitemid 26314236)
30. Sastre M, Regunathan S, and Reis DJ (1997) Uptake of agmatine into rat brain synaptosomes: possible role of cation channels. J Neurochem 69:2421-2426. (Pubitemid 27495428)
31. Share NN and Rackham A (1981) Intracerebral substance P in mice: behavioral effects and narcotic agents. Brain Res 211:379-386.
32. Stone LS, Fairbanks CA, Laughlin TM, Nguyen HO, Bushy TM, Wessendorf MW, and Wilcox GL (1997) Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2. Neuroreport 8:3131-3135. (Pubitemid 27421745)
33. Tallarida RJ and Murray RB (1987) Manual of Pharmacological Calculations with Computer Programs, pp 26-31, Springer Verlag, New York.
34. Tan KK, Brown MJ, Longmore J, Plumpton C, and Hill RG (1994) Demonstration of the neurotransmitter role of calcitonin gene-related peptides (CGRP) by immunoblockade with anti-CGRP monoclonal antibodies. Br J Pharmacol 111:703-710. (Pubitemid 24151653)
35. Tseng LF, Narita M, Suganuma C, Mizoguchi H, Ohsawa M, Nagase H, and Kampine JP (2000) Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse. J Pharmacol Exp Ther 292:576-583. (Pubitemid 30067420)
36. Vanderah TW, Lai J, Yamamura HI, and Porreca F (1994) Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu(5)]enkephalin antiserum-sensitive enhancement of morphine antinociception. Neuroreport 5:2601-2605.
37. Wade CL, Schuster DJ, Domingo KM, Kitto KF, and Fairbanks CF (2008) Supraspinally-administered agmatine attenuates the development of oral fentanyl self-administration. Eur J Pharmacology 587:135-140.
38. Yang XC and Reis DJ (1999) Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neurons. J Pharmacol Exp Ther 288:544-549. (Pubitemid 29119663)
39. Yu CG, Marcillo AE, Fairbanks CA, Wilcox GL, and Yezierski RP (2000) Agmatine improves locomotor function and reduces tissue damage following spinal cord injury. Neuroreport 11:3203-3207.
40. Zadina JE, Hackler L, Ge LJ, and Kastin AJ (1997) A potent and selective endogenous agonist for the mu-opiate receptor. Nature 386:499-502. (Pubitemid 27164076)