Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: Demonstration of an opioid kappa and delta inhibitory tone

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 2, 1996, Pages 784-788

  Ossipov, Michael H ^a   Kovelowski, Carl J ^a   Wheeler Aceto, Helen ^b   Cowan, Alan ^b   Hunter, John C ^c   Lai, Josephine ^a   Malan Jr , T Philip ^a   Porreca, Frank ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINALTORPHIMINE; DELTA OPIATE RECEPTOR; DYNORPHIN; ENKEPHALIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; FORMALDEHYDE; KAPPA OPIATE RECEPTOR; NALOXONE; OPIATE; OPIATE ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG POTENCY; ELECTROPHYSIOLOGY; HYPERALGESIA; INTRATHECAL DRUG ADMINISTRATION; MYELINATION; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SPINAL CORD DORSAL HORN; STIMULUS RESPONSE;

ANIMALS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; FORMALDEHYDE; IMMUNE SERA; MALE; NALOXONE; NALTREXONE; NARCOTIC ANTAGONISTS; OPIOID PEPTIDES; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA;

EID: 0030424507     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. BOURGOIN, S., LEBARS, D., CLOT, A. M., HAMON, M. AND CESSELIN, F.: Subcutaneous formalin induces a segmental release of Met-enkephalin-like material from the rat spinal cord. Pain 41: 323-329, 1990.
2. DICKENSON, A. H. AND SULLIVAN, A. F.: Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: Differential response to an intrathecal opiate administered pre or post formalin. Pain 30: 349-360, 1987.
3. DUBNER, R.: Neuronal plasticity and pain following peripheral tissue inflammation or nerve injury. In Proceedings of the VIth World Congress on Pain, ed. by M. R. Bond, J. E. Charlton and C. J. Woolf, pp. 263-276, Elsevier Science Publishers BV, Amsterdam, 1991.
4. DUBNER, E. AND RUDA, M. A.: Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci. 15: 96-103, 1992.
5. DUBUISSON, D. AND DENNIS, S. G.: The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4: 161-174, 1977.
6. 61-84 possessing selective agonist activity at mu-opioid receptors. Eur. J. Pharmacol. 70: 531-540, 1981.
7. 4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5: 383-386, 1985.
8. HU, X.-M., HU, J. W., HAAS, D. A., VERNON, H. AND SESSLE, B. J.: Opioid involvement in jaw electromyographic (EMG) responses induced by injection of inflammatory irritant into temporomandibular joint (TMJ). Pain (Suppl.) 544, 1993.
9. HUNSKAAR, S. AND HOLE, K.: The formalin test in mice: Dissociation between inflammatory and non-inflammatory pain. Pain 30: 103-114, 1987.
10. HUNT, S. P., PINI, A. AND EVAN, G.: Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature (Lond.) 328: 632-634, 1987.
11. HUNTER, J. C., LEIGHTON, G. E., MEECHAM, K. G., BOYLE, S. J., HORWELL, D. C., REES, D. C. AND HUGHES, J.: CI-977, a novel and selective agonist for the κ-opioid receptor. Br. J. Pharmacol. 101: 183-189, 1990.
12. HUNTER, J. C., WOODBURN, V. L., DURIEUX, C., PETTERSSON, E. K. E., POAT, J. A. AND HUGHES, J.: C-fos antisense oligodeoxynucleotide increases formalin-induced nociception and regulates preprodynorphin expression. Neuroscience 65: 485-492, 1995.
13. IADAROLA, M. J., BHADY, L. S., DRAISCI, G. AND DUBNER, R.: Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: Stimulus specificity, behavioral parameters and opioid receptor binding. Pain 35: 313-326, 1988a.
14. IADAROLA, M. J., DOUGLASS, J., CIVELLI, O. AND NARANJO, J. R.: Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: Evidence using cDNA hybridization. Brain Res. 455: 205-212, 1988b.
15. KOCHER, L.: Systemic naloxone does not affect pain-related behaviour in the formalin test in the rat. Physiol. Behav. 43: 265-268, 1988.
16. MILLAN, M. J., CZLONKOWSKI, A., MORRIS, B., STEIN, C., ARENDT, R., HUBER, A., HOLLT, V. AND HERZ, A.: Inflammation of the hind limb as a model of unilateral, localized pain: Influence on multiple opioid systems in the spinal cord of the rat. Pain 35: 299-312, 1988.
17. MOSBERG, H. I., HURST, R., HRUBY, V. I., GEE, K., YAMAMUBA, H I., GALLICAN, J. J. AND BURKS, T. F.: Bis-penicillamine enkephalins show pronounced delta receptor selectivity. Proc. Natl. Acad. Sci. U.S.A. 80: 5871-5874, 1983.
18. NOGUCHI, K., DUBNER, R. AND RUDA, M. A.: Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is colocalized with Fos and Fos-related proteins. Neuroscience 46: 561-570, 1992.
19. NORTH, M. A.: Naloxone reversal of morphine analgesia but failure to alter reactivity to pain in the formalin test. Life Sci. 22: 295-302, 1978.
20. OSSIPOV, M. H., KOVELOWSKI, C. J. AND PORRECA, F.: The increase in morphine antinociceptive potency produced by carrageenan-induced hindpaw inflammation is blocked by NTI, a selective δ-opioid antagonist. Neuroscience Lett. 184: 173-176, 1995.
21. PORTOGHESE, P. S., LIPKOWSKI, A. W. AND TAKEMORI, A. E.: Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists. Life Sci. 40: 1287-1292, 1987.
22. SOFUOGLU, M., PORTOGHESE, P. S. AND TAKEMORI, A. E.: Differential antagonism of delta opioid agonists by NTI and its benzofuran analog (NTB) in mice: Evidence for delta opioid receptor subtypes. J. Pharmacol. Exp. Ther. 257: 676-680, 1991.
23. TAKEMORI, A. E., LARSON, D. L. AND PORTOGHESE, P. S.: The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone. Eur. J. Pharmacol. 70: 445-451, 1981.
24. TJOLSEN, A., BERGE, O.-G., HUNSKAAR, S., ROSLAND, J. H. AND HOLE, K.: The formalin test: An evaluation of the method. Pain 51: 5-17, 1992.
25. TSENG, L. F. AND COLLINS, K A.: Spinal involvement of both dynorphin A and Met-enkephalin in the antinociception induced by intracerebroventricularly administered bremazocine but not morphine in the mouse. J. Pharmacol. Exp. Ther. 266: 1430-1438, 1993.
26. 5]-enkephalin anti-serum-sensitive enhancement of morphine antinociception. NeuroReport 5: 2601-2605, 1994.
27. VANDERAH, T. W., WILD, K. D., TAKEMORI, A.E., SULTANA, M., POSTOGHESE, P. S., BOWEN, W. D., HRUBY, V. J., MOSBERG, H. I. AND PORRECA, F.: Modulation of morphine antinociception by swim-stress in the mouse: Involvement of supraspinal opioid delta-2 receptors. J. Pharmacol. Exp. Ther. 267: 449-455, 1993.
28. WHEELER-ACETO, H., PORRECA, F. AND COWAN, A.: The rat paw formalin test: Comparison of noxious agents. Pain 40: 229-238, 1990.
29. WHEELER-ACETO, H. AND COWAN, A.: Neurogenic and tissue-mediated components of formalin-induced edema: Evidence for supraspinal regulation. Agents Actions 34: 264-269, 1991.
30. WHEELER-ACETO, H. AND COWAN, A.: Naloxone causes apparent antinociception and pronociception simultaneously in the rat paw test. Eur. J. Pharmacol. 236: 193-199, 1993.
31. WISDEN, W., ERRINGTON, M. L , WILLIAMS, S., DUNNETT, S. B., WATERS, C., HITCHCOCK, D., EVAN, G., BLISS, T. V. P. AND HUNT, S. P.: Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron 4: 603-614, 1990.