Calcineurin and cardiac function: Is more or less better for the heart?

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 5, 2009, Pages

  Wolska, Beata M ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM ION; CALMODULIN; CNA ALPHA HETERODIMER; CNA BETA HETERODIMER; CNB1 HETERODIMER; HETERODIMER; PHOSPHATASE; SERINE THREONINE PHOSPHATASE; UNCLASSIFIED DRUG;

CALCIUM BINDING; EDITORIAL; FATTY ACID OXIDATION; HEART CONTRACTION; HEART DEVELOPMENT; HEART FUNCTION; HEART HEMODYNAMICS; HEART MUSCLE RELAXATION; HEART VENTRICLE HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CALCINEURIN; CALCIUM SIGNALING; CARDIOMYOPATHIES; GENOTYPE; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOCARDIUM; PHENOTYPE; UP-REGULATION;

EID: 70350433732     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00833.2009     Document Type: Editorial

References (16)

1. Boknik P, Fockenbrock M, Herzig S, Knapp J, Linck B, Luss H, Muller FU, Muller T, Schmitz W, Schroder F, Neumann J. Protein phosphatase activity is increased in a rat model of long-term β-adrenergic stimulation. Naunyn Schmiedebergs Arch Pharmacol 362: 222-231, 2000. (Pubitemid 30679077)
2. Bueno OF, Wilkins BJ, Tymitz KM, Glascock BJ, Kimball TF, Lorenz JN, Molkentin JD. Impaired cardiac hypertrophic response in calcineurin Aβ-deficient mice. Proc Natl Acad Sci USA 99: 4586-4591, 2002. (Pubitemid 34286028)
3. 2+ handling in a calcineurin transgenic model of heart failure. Cardiovasc Res 54: 105-116, 2002.
4. DiPaola NR, Sweet WE, Stull LB, Francis GS, Schomisch MC. β-Adrenergic receptors and calcium cycling proteins in non-failing, hypertrophied and failing human hearts: transition from hypertrophy to failure. J Mol Cell Cardiol 33: 1283-1295, 2001.
5. 2+/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell 105: 863-875, 2001.
6. Luss H, Klein-Wiele O, Boknik P, Herzig S, Knapp J, Linck B, Muller FU, Scheld HH, Schmid C, Schmitz W, Neumann J. Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart. J Mol Cell Cardiol 32: 2349-2359, 2000. (Pubitemid 32042138)
7. MacDougall LK, Jones LR, Cohen P. Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban. Eur J Biochem 196: 725-734, 1991.
8. MacLennan DH, Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4: 566-577, 2003.
9. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93: 215-228, 1998. (Pubitemid 28180855)
10. Rusnak F, Mertz P. Calcineurin: form and function. Physiol Rev 80: 1483-1521, 2000.
11. Santana LF, Chase EG, Votaw VS, Nelson MT, Greven R. Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes. J Physiol 544: 57-69, 2002. (Pubitemid 35153813)
12. Schaeffer PJ, Desantiago J, Yang JH, Flagg TP, Kovacs A, Weinheimer C, Courtois MR, Leone TC, Nichols CG, Bers DM, Kelly DP. Impaired contractile function and calcium handling in hearts of cardiacspecific calcineurin B1-deficient mice. Am J Physiol Heart Circ Physiol (August 21, 2009). doi:10.1152/ajpheart.00152.2009.
13. Schaeffer PJ, Wende AR, Magee CJ, Neilson JR, Leone TC, Chen F, Kelly DP. Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle. J Biol Chem 279: 39593-39603, 2004. (Pubitemid 39258226)
14. Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR, Molkentin JD. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res 94: 110-118, 2004. (Pubitemid 38064105)
15. Wilkins BJ, Molkentin JD. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun 322: 1178-1191, 2004. (Pubitemid 39164648)
16. Zhang BW, Zimmer G, Chen J, Ladd D, Li E, Alt FW, Wiederrecht G, Cryan J, O'Neill EA, Seidman CE, Abbas AK, Seidman JG. T cell responses in calcineurin A alpha-deficient mice. J Exp Med 183: 413-420, 1996. (Pubitemid 26060790)