Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction

American Journal of Rhinology

Volumn 21, Issue 3, 2007, Pages 346-353

  Chen, Bei ^a   Antunes, Marcelo B ^a,b   Claire, Steven Eau ^a   Palmer, James N ^a,b   Chiu, Alexander G ^a,b   Kennedy, David W ^b   Cohen, Noam A ^a,b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

ATP; Chronic rhinosinusitis; Ciliary beat frequency; Isoproterenol; Methacholine; Mucociliary clearance; Sinonasal polyps; Stimulation

Indexed keywords

ADENOSINE TRIPHOSPHATE;

ADOLESCENT; ADULT; AGED; ARTICLE; CILIARY MOTILITY; CILIATED EPITHELIUM; CONTROLLED STUDY; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; EX VIVO STUDY; FEMALE; HEREDITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MUCOCILIARY CLEARANCE; NOSE CAVITY; NOSE POLYP; PARANASAL SINUS; PARANASAL SINUS DISEASE; PATHOGENESIS; PHASE CONTRAST MICROSCOPY; RHINOSINUSITIS; SINONASAL CILIARY DYSFUNCTION; TEMPERATURE SENSITIVITY;

ADOLESCENT; ADULT; CELL CULTURE TECHNIQUES; CHRONIC DISEASE; CILIA; FEMALE; HUMANS; MALE; MIDDLE AGED; PARANASAL SINUSES; RESPIRATORY MUCOSA; RHINITIS; SINUSITIS;

EID: 34347273078     PISSN: 10506586     EISSN: None     Source Type: Journal    
DOI: 10.2500/ajr.2007.21.3029     Document Type: Article

References (73)

1. Blackwell D, Collins J, and Coles R. Summary health statistics for U.S. adults: National Health Interview Survey, 1997. National Center for Health Statistics. Vital Health Stat 10:15, 2002.
2. Cherry DK, and Woodwell DA. National Ambulatory Medical Care Survey: 2000 summary. Adv Data 1-32, 2002.
3. Ly N, and McCaig LF. National Hospital Ambulatory Medical Care Survey: 2000 outpatient department summary. Adv Data 1-27, 2002.
4. Ray NF, Baraniuk JN, Thamer M, et al. Healthcare expenditures for sinusitis in 1996: Contributions of asthma, rhinitis, and other airway disorders. J Allergy Clin Immunol 103: 408-414, 1999.
5. Murphy MP, Fishman P, Short SO, et al. Health care utilization and cost among adults with chronic rhinosinusitis enrolled in a health maintenance organization. Otolaryngol Head Neck Surg 127:367-376, 2002.
6. Gliklich RE, and Metson R. The health impact of chronic sinusitis in patients seeking otolaryngologic care. Otolaryngol Head Neck Surg 113:104-109, 1995.
7. Wanner A, Salathe M, and O'Riordan TG. Mucociliary clearance in the airways. Am J Respir Crit Care Med 154:1868-1902, 1996.
8. Sanderson MJ, and Sleigh MA. Ciliary activity of cultured rabbit tracheal epithelium: Beat pattern and metachrony. J Cell Sci 47:331-347, 1981.
9. Messerklinger W. Direction of ciliary flow on the mucosa of the upper respiratory tract. Z Laryngol Rhinol Otol 30:302-308, 1951.
10. Sanderson MJ, and Dirksen ER. Mechanosensitivity of cultured ciliated cells from the mammalian respiratory tract: Implications for the regulation of mucociliary transport. Proc Natl Acad Sci U S A 83:7302-7306, 1986.
11. Wong LB, Miller IF, and Yeates DB. Stimulation of tracheal ciliary beat frequency by capsaicin. J Appl Physiol 68:2574-2580, 1990.
12. Jain B, Rubinstein I, Robbins RA, et al. TNF-alpha and IL-1 beta upregulate nitric oxide-dependent ciliary motility in bovine airway epithelium. Am J Physiol 268:L911-L917, 1995.
13. Korngreen A, Ma W, and Priel Z, et al. Extracellular ATP directly gates a cation-selective channel in rabbit airway ciliated epithelial cells. J Physiol 508:703-720, 1998.
14. Sanderson MJ, and Dirksen ER. Mechanosensitive and beta-adrenergic control of the ciliary beat frequency of mammalian respiratory tract cells in culture. Am Rev Respir Dis 139:432-440, 1989.
15. Mwimbi XK, Muimo R, Green MW, et al. Making human nasal cilia beat in the cold: A real time assay for cell signalling. Cell Signal 15:395-402, 2003.
16. Silberberg A. On mucociliary transport. Biorheology 27:295-307, 1990.
17. Seybold ZV, Mariassy AT, Stroh D, et al. Mucociliary interaction in vitro: Effects of physiological and inflammatory stimuli. J Appl Physiol 68:1421-1426, 1990.
18. Picher M, and Boucher RC. Human airway ecto-adenylate kinase. A mechanism to propagate ATP signaling on airway surfaces. J Biol Chem 278:11256-11264, 2003.
19. Wyatt TA, and Sisson JH. Chronic ethanol downregulates PKA activation and ciliary beating in bovine bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 281:L575-L581, 2001.
20. Yang B, Schlosser RJ, and McCaffrey TV. Dual signal transduction mechanisms modulate ciliary beat frequency in upper airway epithelium. Am J Physiol 270:L745-L751, 1996.
21. Salathe M, Lipson EJ, Ivonnet PI, et al. Muscarinic signaling in ciliated tracheal epithelial cells: Dual effects on Ca2+ and ciliary beating. Am J Physiol 272:L301-L310, 1997.
22. Zagoory O, Braiman A, and Priel Z. The mechanism of ciliary stimulation by acetylcholine: Roles of calcium, PKA, and PKG. J Gen Physiol 119:329-339, 2002.
23. Gayner SM, and McCaffrey TV. Muscarinic ciliostimulation requires endogenous prostaglandin production. Am J Rhinol 12:203-207, 1998.
24. Wong LB, Miller IF, and Yeates DB. Pathways of substance P stimulation of canine tracheal ciliary beat frequency. J Appl Physiol 70:267-273, 1991.
25. Wong LB, Park CL, and Yeates DB. Neuropeptide Y inhibits ciliary beat frequency in human ciliated cells via nPKC, independently of PKA. Am J Physiol 275:C440-C448, 1998.
26. Elwany S, Hisham M, and Gamaee R. The effect of endoscopic sinus surgery on mucociliary clearance in patients with chronic sinusitis. Eur Arch Otorhinolaryngol 255:511-514, 1998.
27. Majima Y, Sakakura Y, Matsubara T, et al. Mucociliary clearance in chronic sinusitis: Related human nasal clearance and in vitro bullfrog palate clearance. Biorheology 20:251-262, 1983.
28. Passali D, Ferri R, Becchini G, et al. Alterations of nasal mucociliary transport in patients with hypertrophy of the inferior turbinates, deviations of the nasal septum and chronic sinusitis. Eur Arch Otorhinolaryngol 256:335-337, 1999.
29. Dal T, Onerci M, and Caglar M. Mucociliary function of the maxillary sinuses after restoring ventilation: A radioisotopic study of the maxillary sinus. Eur Arch Otorhinolaryngol 254:205-207, 1997.
30. Kaluskar SK. Pre- and postoperative mucociliary clearance in functional endoscopic sinus surgery. Ear Nose Throat J 76:884-886, 1997.
31. Hafner B, Davris S, Riechelmann H, et al. Endonasal sinus surgery improves mucociliary transport in severe chronic sinusitis. Am J Rhinol 11:271-274, 1997.
32. Asai K, Haruna S, Otori N, et al. Saccharin test of maxillary sinus mucociliary function after endoscopic sinus surgery. Laryngoscope 110:117-122, 2000.
33. Majima Y, Sakakura Y, Matsubara T, et al. Possible mechanisms of reduction of nasal mucociliary clearance in chronic sinusitis. Clin Otolaryngol 11:55-60, 1986.
34. Ikeda K, Oshima T, Furukawa M, et al. Restoration of the mucociliary clearance of the maxillary sinus after endoscopic sinus surgery. J Allergy Clin Immunol 99:48-52, 1997.
35. Inanli S, Tutkun A, Batman C, et al. The effect of endoscopic sinus surgery on mucociliary activity and healing of maxillary sinus mucosa. Rhinology 38:120-123, 2000.
36. Majima Y, Harada T, Shimizu T, et al. Effect of biochemical components on rheologic properties of nasal mucus in chronic sinusitis. Am J Respir Crit Care Med 160:421-426, 1999.
37. Atsuta S, and Majima Y. Nasal mucociliary clearance of chronic sinusitis in relation to Theological properties of nasal mucus. Ann Otol Rhinol Laryngol 107:47-51, 1998.
38. Joki S, Toskala E, Saano V, et al. Correlation between ciliary beat frequency and the structure of ciliated epithelia in pathologic human nasal mucosa. Laryngoscope 108:426-430, 1998.
39. Braverman I, Wright ED, Wang CG, et al. Human nasal ciliary-beat frequency in normal and chronic sinusitis subjects. J Otolaryngol 27:145-152, 1998.
40. Nuutinen J, Rauch-Toskala E, Saano V, et al. Ciliary beating frequency in chronic sinusitis. Arch Otolaryngol Head Neck Surg 119:645-647, 1993.
41. Saano V, Nuutinen J, Virta P, et al. The effect of ATP on the ciliary activity of normal and pathological human respiratory mucosa in vitro. Acta Otolaryngol 111:130-134, 1991.
42. Chen B, Shaari J, Claire SE, et al. Altered sinonasal ciliary dynamics in chronic rhinosinusitis. Am J Rhinol 20:325-329, 2006.
43. Shaari J, Palmer JN, Chiu AG, et al. Regional analysis of sinonasal ciliary beat frequency. Am J Rhinol 20:150-154, 2006.
44. Schipor I, Palmer JN, Cohen AS, et al. Quantification of ciliary beat frequency in sinonasal epithelial cells using differential interference contrast microscopy and high-speed digital video imaging. Am J Rhinol 20:124-127, 2006.
45. Hayashi T, Kawakami M, Sasaki S, et al. ATP regulation of ciliary beat frequency in rat tracheal and distal airway epithelium. Exp Physiol 90:535-544, 2005.
46. Allen-Gipson DS, Romberger DJ, Forget MA, et al. IL-8 inhibits isoproterenol-stimulated ciliary beat frequency in bovine bronchial epithelial cells. J Aerosol Med 17:107-115, 2004.
47. Eliezer N, Sade J, Silberberg A, et al. The role of mucus in transport by cilia. Am Rev Respir Dis 102:48-52, 1970.
48. Scadding GK, Lund VJ, and Darby YC. The effect of long-term antibiotic therapy upon ciliary beat frequency in chronic rhinosinusitis. J Laryngol Otol 109:24-26, 1995.
49. Ohashi Y, and Nakai Y. Reduced ciliary action in chronic sinusitis. Acta Otolaryngol Suppl 397:3-9, 1983.
50. Ohashi Y, and Nakai Y. Functional and morphological pathology of chronic sinusitis mucous membrane. Acta Otolaryngol Suppl 397:11-48, 1983.
51. Hattori M. Mucociliary function of chronic inflammation in upper and lower airways. Auris Nasus Larynx 21:219-225, 1994.
52. Rutland J, and Cole PJ. Nasal mucociliary clearance and ciliary beat frequency in cystic fibrosis compared with sinusitis and bronchiectasis. Thorax 36:654-658, 1981.
53. Jain B, Rubinstein I, Robbins RA, et al. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem Biophys Res Commun 191:83-88, 1993.
54. Mogami Y, Pernberg J, and Machemer H. Messenger role of calcium in ciliary electromotor coupling: A reassessment. Cell Calcium 11:665-673, 1990.
55. Salathe M, and Bookman RJ. Coupling of [Ca2+]i and ciliary beating in cultured tracheal epithelial cells. J Cell Sci 108: 431-440, 1995.
56. Korngreen A, and Priel Z. Simultaneous measurement of ciliary beating and intracellular calcium. Biophys J 67:377-380, 1994.
57. Braiman A, Zagoory O, and Priel Z. PKA induces Ca2+ release and enhances ciliary beat frequency in a Ca2+-dependent and -independent manner. Am J Physiol 275:C790-C797, 1998.
58. Zhang L, and Sanderson MJ. The role of cGMP in the regulation of rabbit airway ciliary beat frequency. J Physiol 551: 765-776, 2003.
59. Wyatt TA, Spurzem JR, May K, et al. Regulation of ciliary beat frequency by both PKA and PKG in bovine airway epithelial cells. Am J Physiol 275:L827-L835, 1998.
60. Yang B, Schlosser RJ, and McCaffrey TV. Signal transduction pathways in modulation of ciliary beat frequency by methacholine. Ann Otol Rhinol Laryngol 106:230-236, 1997.
61. Uzlaner N, and Priel Z. Interplay between the NO pathway and elevated [Ca2+]i enhances ciliary activity in rabbit trachea. J Physiol 516:179-190, 1999.
62. Korngreen A, and Priel Z. Purinergic stimulation of rabbit ciliated airway epithelia: Control by multiple calcium sources. J Physiol 497:53-66, 1996.
63. Barrera NP, Morales B, and Villalon M. Plasma and intracellular membrane inositol 1,4,5-trisphosphate receptors mediate the Ca(2+) increase associated with the ATP-induced increase in ciliary beat frequency. Am J Physiol Cell Physiol 287:C1114-C1124, 2004.
64. Ma W, Silberberg SD, and Priel Z. Distinct axonemal processes underlie spontaneous and stimulated airway ciliary activity. J Gen Physiol 120:875-885, 2002.
65. Gertsberg I, Hellman V, Fainshtein M, et al. Intracellular Ca2+ regulates the phosphorylation and the dephosphorylation of ciliary proteins via the NO pathway. J Gen Physiol 124:527-540, 2004.
66. Hamilos DL. Chronic sinusitis. J Allergy Clin Immunol 106: 213-227, 2000.
67. Lennard CM, Mann EA, Sun LL, et al. Interleukin-1 beta, interleukin-5, interleukin-6, interleukin-8, and tumor necrosis factor-alpha in chronic sinusitis: Response to systemic corticosteroids. Am J Rhinol 14:367-373, 2000.
68. Kuehnemund M, Ismail C, Brieger J, et al. Untreated chronic rhinosinusitis: A comparison of symptoms and mediator profiles. Laryngoscope 114:561-565, 2004.
69. Bachert C, Wagenmann M, Rudack C, et al. The role of cytokines in infectious sinusitis and nasal polyposis. Allergy 53:2-13, 1998.
70. Bachert C, Wagenmann M, Hauser U, et al. IL-5 synthesis is upregulated in human nasal polyp tissue. J Allergy Clin Immunol 99:837-842, 1997.
71. Bachert C, and Van Cauwenberge PB. Inflammatory mechanisms in chronic sinusitis. Acta Otorhinolaryngol Belg 51: 209-217, 1997.
72. Woodworth BA, Joseph K, Kaplan AP, et al. Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps. Otolaryngol Head Neck Surg 131:585-589, 2004.
73. Laoukili J, Perret E, Willems T, et al. IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. J Clin Invest 108:1817-1824, 2001.