Male specific association between the 5-HTR6 gene 267C/T SNP and suicide in the Portuguese population

Neuroscience Letters

Volumn 466, Issue 3, 2009, Pages 128-130

  Azenha, Diana ^a   Alves, Mariana ^a   Matos, Rita ^a   Santa, Jerónimo Fonte ^a   Silva, Beatriz ^a   Cordeiro, Cristina ^a   Vieira, Duarte Nuno ^a,b   Ambrósio, Alda M ^a,b  

^a INSTITUTO NACIONAL DE MEDICINA LEGAL E CIÊNCIAS FORENSES   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

267C T SNP; 5 HTR6 gene; Genetics; Male suicide victims

Indexed keywords

CYTOSINE; SEROTONIN 6 RECEPTOR; THYMINE;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENDER; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; POPULATION RESEARCH; PORTUGAL; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDE; VICTIM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PORTUGAL; RECEPTORS, SEROTONIN; SEX FACTORS; SUICIDE; YOUNG ADULT;

EID: 70350348358     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.09.040     Document Type: Article

References (26)

1. Baca-García E., Vaquero C., Diaz-Sastre C., Saiz-Ruiz J., Fernández-Piqueras J., and de Leon J. A gender-specific association between the serotonin transporter gene and suicide attempts. Neuropsychopharmacology 26 (2002) 692-695
2. Brezo J., Klempan T., and Turecki G. The genetics of suicide: a critical review of molecular studies. Psychiatr. Clin. North Am. 31 (2008) 179-203
3. Du L., Faludi G., Palkovits M., Demeter E., Bakish D., Lapierre Y.D., Sótonyi P., and Hrdina P.D. Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims. Biol. Psychiatry 46 (1999) 196-201
4. Dubertret C., Hanoun N., Adès J., Hamon M., and Gorwood P. Family-based association study of the serotonin-6 receptor gene (C267T polymorphism) in schizophrenia. Am. J. Med. Genet. 126B (2004) 10-15
5. East S.Z., Burnet P.W.J., Kerwin R.W., and Harrison P.J. An RT-PCR study of 5-HT6 and 5-HT7 receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia. Schizophr. Res. 57 (2002) 15-26
6. Hirst W.D., Abrahamsen B., Blaney F.E., Calver A.R., Aloj L., Price G.W., and Medhurst A.D. Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modelling. Mol. Pharmacol. 64 (2003) 1295-1308
7. Hong C.-J., Tsai S.-J., Cheng C.-Y., Liao W.-Y., Song H.-L., and Lai H.-C. Association analysis of the 5-HT6 receptor polymorphism (C267T) in mood disorders. Am. J. Med. Genet. 88 B (1999) 601-602
8. King M.V., Marsden C.A., and Fone K.C.F. A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory. Trends Pharmacol. Sci. 29 (2008) 482-492
9. Kohen R., Metcalf M.A., Khan N., Druck T., Huebner K., Lachowicz J.E., Meltzer H.Y., Sibley D.R., Roth B.L., and Hamblin M.W. Cloning, characterization, and chromosomal localization of a human 5-HT6 Serotonin receptor. J. Neurochem. 66 (1996) 47-56
10. 6 receptor gene variations in healthy adults. J. Psychiatry Neurosci. 33 (2008) 47-53
11. Lee S.-H., Lee K.-J., Lee H.-J., Ham B.-J., Ryu S.-H., and Lee M.-S. Association between the 5-HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder. Psychiatry Clin. Neurosci. 59 (2005) 140-145
12. Limosin F., Loze J.Y., Boni C., Hamon M., Adès J., Rouillon F., and Gorwood P. Male-specific association between the 5-HTTLPR S allele and suicide attempts in alcohol-dependent subjects. J. Psychiatr. Res. 39 (2004) 179-182
13. 6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex. Psychopharmacology 196 (2008) 93-104
14. Mann J.J. Role of the serotonergic system in the pathogenesis of major depression and suicidal behaviour. Neuropsychopharmacology 21 (1999) 99S-105S
15. Marcos B., Chuang T.T., Gil-Bea F.J., and Ramirez M.J. Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat. Br. J. Pharmacol. 155 (2008) 434-440
16. Miller S.A., Dykes D.D., and Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16 (1988) 1215
17. Meltzer H.Y., Alphs L., Green A.I., Altamura A.C., Anand R., Bertoldi A., Bourgeois M., Chouinard G., Islam M.Z., Kane J., Krishnan R., Lindnmayer J.P., and Potkin S. International suicide prevention trial study group, Clozapine treatment for suicidality in schizophrenia: international suicide prevention trial (interSePT). Arch. Gen. Psychiatry 60 (2003) 82-91
18. 6 receptor gene polymorphisms and suicide victims. Psychiatry Clin. Neurosci. 59 (2005) 345-349
19. Palmer B.A., Pankratz V.S., and Bostwick J.M. The lifetime risk of suicide in schizophrenia: a reexamination. Arch. Gen. Psychiatry 62 (2005) 247-253
20. Purselle D.C., and Nemeroff C.B. Serotonin transporter: a potential substrate in the biology of suicide. Neuropsychopharmacology 28 (2003) 613-619
21. Raust A., Slama F., Mathieu F., Roy I., Chenu A., Koncke D., Fouques D., Jollant F., Jouvent E., Courtet P., Leboyer M., and Bellivier F. Prefrontal cortex dysfunction in patients with suicidal behavior. Psychol. Med. 37 (2007) 411-419
22. Shinkai T., Ohmori O., Kojima H., Terao T., Suzuki T., and Abe K. Association study of the 5-HT6 receptor gene in schizophrenia. Am. J. Med. Genet. 88B (1999) 120-122
23. Tsai S.J., Chiu H.J., Wang Y.C., and Hong C.J. Association study of serotonin-6 receptor variant (C267T) with schizophrenia and aggressive behavior. Neurosci. Lett. 271 (1999) 135-137
24. Turecki G., Sequeira A., Gingras Y., Séguin M., Lesage A., Tousignant M., Chawky N., Vanier C., Lipp O., Benkelfat C., and Rouleau G.A. Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. Am. J. Med. Genet. 118B (2003) 36-40
25. Vogt I.R., Shimron-Abarbanell D., Neidt H., Erdmann J., Cichon S., Schulze T.G., Müller D.J., Maier W., Albus M., Borrmann-Hassenbach M., Knapp M., Rietschel M., Propping P., and Nöthen M.M. Investigation of the human serotonin 6 (5-HT6) receptor gene in bipolar affective disorder and schizophrenia. Am. J. Med. Genet. 96B (2000) 217-221
26. Zill P., Buttner A., Eisenmenger W., Moler H.J., Bondy B., and Ackenheil M. Single nucleotide polymorphism and haplotype analysis of a novel Trytophan Hydroxilase Isoform (TPH2) gene in suicide victims. Biol. Psychiatry 56 (2004) 581-586