Towards a better understanding of the psychopharmacology of nutmeg: Activities in the mouse tetrad assay

Journal of Ethnopharmacology

Volumn 126, Issue 2, 2009, Pages 280-286

  El Alfy, Abir T ^a   Wilson, Lisa ^a   ElSohly, Mahmoud A ^b,c   Abourashed, Ehab A ^d  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c ElSohly Laboratories Incorporated   (United States)

^d CHICAGO STATE UNIVERSITY   (United States)

Author keywords

9 Tetrahydrocannabinol; Amphetamine; HPLC; Morphine; Mouse tetrad assay; Myristica fragrans; Nutmeg

Indexed keywords

AMPHETAMINE; DRONABINOL; MORPHINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORE TEMPERATURE; DRUG ABUSE; HOT PLATE TEST; LOCOMOTION; MALE; MOUSE; NONHUMAN; NUTMEG; PSYCHOPHARMACOLOGY; RECTUM TEMPERATURE; TAIL FLICK TEST;

AMPHETAMINE; ANIMALS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MICE, INBRED STRAINS; MORPHINE; MOTOR ACTIVITY; MYRISTICA FRAGRANS; PAIN THRESHOLD; PLANT EXTRACTS; PSYCHOPHARMACOLOGY; RECTUM; SEEDS; TEMPERATURE; TETRAHYDROCANNABINOL;

MUS; MYRISTICA FRAGRANS; MYRISTICACEAE;

EID: 70350346860     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.08.026     Document Type: Article

References (47)

1. Abdul Wahab U.H.R., Ahmed A., Khan R., and Raza M. Anticonvulsant activities of nutmeg oil of Myristica fragrans. Phytotherapy Research 23 (2009) 153-158
2. Beck T., and Marty H. Die Nervenkekse der Hildgard von Bingenkeine harmlose Nascherei. Schweiz Med Forum 51/52 (2001) 1287-1288
3. Beyer J., Ehlers D., and Maurer H.H. Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients Elemicin, Myristicin, and Safrole in rat and human urine using gas chromatography/mass spectrometry. Therapeutic Drug Monitoring 28 (2006) 568-575
4. Braun U.K.D. Evidence for the biogenic formation of amphetamine derivatives from components of nutmeg. Pharmacology 9 (1973) 312-316
5. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd ed. (1999), Lavoisier Publishing Inc., Secaucus, NJ
6. Callaway C., and Clark R. Hyperthermia in psychostimulant overdose. Annals of Emergency Medicine 24 (1994) 68-76
7. Chaperon F., and Thiebot M.H. Behavioral effects of cannabinoid agents in animals. Critical Reviews in Neurobiology 13 (1999) 243-281
8. Chapman C., Casey K., Dubner R., Foley K., Gracely R., and Reading A. Pain measurement: an overview. Pain 22 (1985) 1-31
9. Connor J., Makonnen E., and Rostom A. Comparison of analgesic effects of khat (Catha edulis Forsk) extract, d-amphtemine, and ibuprofen in mice. Journal of Pharmacy and Pharmacology 52 (2000) 107-110
10. de Mello A., Carlini E., Dressler k., Green J., Kang S., and Margolis S. Behavioral observations on compounds found in nutmeg. Psychopharmacologia 31 (1973) 349-363
11. Demetriades A.K., Wallman P.D., McGuiness A., and Gavalas M.C. Low cost, high risk: accidental nutmeg intoxication. Emergency Medicinal Journal 22 (2005) 223-225
12. Dhingra D., Parle M., and kulkarni S. Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myritica fragrans, ascorbic acid, and metrofinate in mice. Journal of Medicinal Food 9 (2006) 281-283
13. Dhingra D., and Sharma A. Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice. Journal of Medicinal Foods 9 (2006) 84-89
14. Engelbrecht J., Long J., Nichols D., and Barfknecht C. Pharmacologic evaluation of 3,4-dimethoxyphenylpropenes and 3,4-dimethoxyphenylpropanediols. Archives Internationales de Pharmacodynamie et de Therapie 2 (1972) 226-244
15. Evans W.C. Treese and Evans Pharmacognosy. 14th ed. (1996), Harcourt Brace & Co. Asia, Singapore p. 273
16. Forrester M.B. Nutmeg intoxication in Texas, 1998-2004. Human and Experimental Toxicology 24 (2005) 563-566
17. Geffen Y.N.A., Gil-Ad I., Rephaeli A., Huang M., Savitsky K., Klapper L., Winkler I., Meltzer H., and Weizman A. BL-1020: a novel antipsychotic drug with GABAergic activity and low catalepsy, is efficacious in a rat model of schizophrenia. European Neuropsychopharmacology 19 (2009) 1-13
18. Glennon R. Do classical hallucinogens act as 5-HT2 agonists or antagonists?. Neuropsychopharmacology 3 (1990) 509-517
19. Janssen J., and Lackman G. Nutmeg oil: identification and quantification of its most active constituents as inhibitors of platelet aggregation. Journal of Ethnopharmacology 29 (1990) 179-188
20. Kelly B.D., Clarke M.M., Gavin B.E., Lane A.A., and Larkin C.C. Nutmeg and psychosis. Schizophrenia Research 60 (2003) 95-96
21. Krasnova I., Ladenheim B., Jayanthi S., Oyler J., Moran T., Huestis M., and Cadet J. Amphetamine-induced toxicity in dopamine terminals in CD-1 and C57BL/6J mice: complex role for oxygen-based species and temperature regulation. Neuroscience 107 (2001) 265-274
22. Lopes L., Pereira S., Silva L., Figueiredo K., Moura B., Almeida F., and Sousa F. Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents. Life Sciences 84 (2009) 105-110
23. Martin B.R., Compton D.R., Prescott W.R., Barret R.L., and Razdan R.K. Pharmacological evaluation of dimethylheptyl analogs of delta9-THC: reassessment of the putative three-point cannabinoid-receptor interaction. Drug and Alcohol Dependence 37 (1994) 231-240
24. McKenna A., Nordt S., and Ryan J. Acute nutmeg poisoning. European Journal of Emergency Medicine 11 (2004) 241
25. Morita T., Jinno K., Kawagishi H., Arimoto Y., Suganuma H., Inakuma T., and Sugiyama K. Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/D-galactosamine-induced liver injury. Journal of Agricultural and Food Chemistry 51 (2003) 1560-1565
26. Mukherjee P., Kumar V., and Houghton P. Screening of Indian Medicinal Plants for Acetylcholinesterase Inhibitory Activity (2007) pp. 1142-1145
27. Nadkarni K. Indian materia medica. 3rd ed. (1998), Bombay Popular Prakashan, Mumbai p. 830
28. Olajide O.A., Ajayi F.F., Ekhelar A.I., Awe S.O., Makinde J.M., and Alada A.R.A. Biological effects of Myristica fragrans (nutmeg) extract. Phytotherapy Research 13 (1999) 344-345
29. Parle M., Dhingra D., and kulkarni S. improvement of mouse memory by Myristica fragrans seeds. Journal of Medicinal Foods 7 (2004) 157-161
30. Pertwee R.G., Thomas A., Stevenson L.A., Ross R.A., Varvel S.A., Lichtman A.H., Martin B.R., and Razdan R.K. The psychoactive plant cannabinoid, delta9-tetrahydrocannabinol, is antagonized by delta8-and delta9-tetrahydrocannabivarin in mice in vivo. British Journal of Pharmacology 150 (2007) 586-594
31. Quin G., Fanning N., and Plunkett P. Nutmeg intoxication. Letters, Notice, Book reviews (1998) 287-288
32. Rudgley R. The Encyclopedia of Psychoactive Substances (1998), Thomas Dunne Books, St. Martin's Griffin
33. Salminen Jr. W., Voellmy R., and Roberts S. Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein adduction. Toxicology and Applied Pharmacology 147 (1997) 247-258
34. Sangalli B.C., and Chiang W. Toxicology of nutmeg abuse. Clinical Toxicology 38 (2000) 671-678
35. Scholefield, J.H., 1995. Nutmeg-an unusual overdose. Letters to the editor, pp. 154-155.
36. Servan J., Cochon F., and Dulocos H. Hallucinations after voluntary ingestion of nutmeg: an unrecognized drug abuse. Reviews in Neurological Diseases (Paris) 154 (1998) 708
37. Shafran I. Letter: nutmeg toxicity. The New England Journal of Medicine 294 (1976) 849
38. Shulgin A.T. Possible implication of myristicin asa psychotropic substance. Nature 210 (1966) 380-384
39. Solheim E., and Scheline R. Metabolism of alkylbenzene derivatives in the rat. I. p-Methoxyallylbenzene (Estragole) and p-methoxypropenylbenzene (Anethole). Xenobiotica 3 (1973) 493-510
40. Sonavane G.S., Sarveiya V.P., Kasture V.S., and Kasture S.B. Behavioral actions of Myristica fragrans seeds. Indian Journal of Pharmacology 33 (2001) 417-424
41. Sonavane G.S., Sarveiya V.P., Kasture V.S., and Kasture S.B. Anxiogenic activity of myristica fragrans seeds. Pharmacology, Biochemistry, and Behavior 71 (2002) 247-252
42. Stein U., Greyer H., and Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Science International 118 (2001) 87-90
43. Takikawa A., Abe K., Yamamoto M., Ishimaru S., Yasui M., Okubo Y., and Yokoigawa K. Anti microbial Activity of Nutmeg against Escherichia coli O157. Journal of Bioscience and Bioenginering 94 (2002) 315-320
44. Truitt E., Callaway E.B.M., and Krantz J. The pharmacology of myristicin: a contribution to the psychopharmacology of nutmeg. Journal of Neuropsychiatry 2 (1961) 205-210
45. Varvel S.A., Bridgen D.T., Tao Q., Thomas B.F., Martin B.R., and Lichtman A.H. Delta9-tetrahydrocannbinol accounts for the antinociceptive, hypothermic, and cataleptic effects of marijuana in mice. The Journal of Pharmacology and Experimental Therapeutics 314 (2005) 329-337
46. Wiley J., and Martin B. Cannabinoid pharmacological properties common to other centrally acting drugs. European Journal of Pharmacology 471 (2003) 185-193
47. Yates J., Meij J., Sullivan J., Richtand N., and Yu L. Bimodal effect of amphetamine on motor behaviors in C57BL/6 mice. Neuroscience Letters 427 (2007) 66-70