Comparison of analgesic effects of khat (Catha edulis Forsk) extract, D-amphetamine and ibuprofen in mice

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 1, 2000, Pages 107-110

  Connor, John ^a   Makonnen, Eyasu ^b   Rostom, Amr ^b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b ADDIS ABABA UNIVERSITY   (Ethiopia)

Author keywords

[No Author keywords available]

Indexed keywords

CATHA EDULIS EXTRACT; DEXAMPHETAMINE; IBUPROFEN; NATURAL PRODUCT;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; HERBAL MEDICINE; HOT PLATE TEST; MALE; MOUSE; NONHUMAN; PAIN; TAIL FLICK TEST;

CATHA EDULIS;

EID: 0034056196     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001773580     Document Type: Article

References (11)

1. Brooks, P. M., Day, R. O. (1991) Nonsteroidal anti-inflammatory drugs - differences and similarities. N. Engl. J. Med. 324: 1716-1725
2. D'Amour, F. E., Smith, D. L. (1941) A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72: 174-179
3. Dewey, W. L., Brase, D., Welch, S. P. (1994) Pain control with opioid analgesics. In: Brody, T. M., Lamer, J., Minnemann, K. P., Neu, H. C. (eds) Human Pharmacology. 2nd edn, Mosby, St Louis, pp 373-388
4. Görlitz, B. D., Frey, H. H. (1972) Central monoamines and antinociceptive drug action. Eur. J. Pharmacol. 20: 171-180
5. Kalix, P. (1992) Cathinone, a natural amphetamine. Pharmacol. Toxicol. 70: 77-86
6. Koster, R., Anderson, M., DeBeer, E. J. (1959) Acetic acid for analgesic screening. Fed. Proc. 18: 412
7. Nencini, P., Ahmed, A. M. (1982) Naloxone reversible antinociceptive activity of cathinone, the active principle of khat, in the mouse and rat. Pharmacol. Res. Commun. 14: 759-770
8. O'Callaghan, J. P., Holtzman, S. G. (1975) Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure. J. Pharmacol. Exp. Ther. 192: 497-505
9. Sparago, M., Wios, J., Yuan, J., Hatzidimitriou, G., Tolliver, J., Dal-Cason, T. A., Katz, J., Ricaurte, G. (1996) Neurotoxic and pharmacologic studies on enantiomers of the N-methylated analog of cathinone (methcathinone): a new drug of abuse. J. Pharmacol. Exp. Ther. 279: 1043-1052
10. Trentin, A. P., Santos, A. R. S., Miguel, O. G., Pizzolatti, M. G., Yanes, R. A., Calixto, J. B. (1997) Mechanisms involved in the antinociceptive effect in mice of the hydroalcoholic extract of Siphocampylus verticillatus. J. Pharm. Pharmacol. 49: 567-572
11. Widler, P., Mathys, K., Brenneisen, R., Kalix, P., Fisch, H. U. (1994) Pharmacodynamics and pharmacokinetics of khat: a controlled study. Clin. Pharmacol. Ther. 55: 556-562