Quinolinol and peptide inhibitors of zinc protease in botulinum neurotoxin A: Effects of zinc ion and peptides on inhibition

Archives of Biochemistry and Biophysics

Volumn 491, Issue 1-2, 2009, Pages 75-84

  Lai, Huiguo ^a   Feng, Minghao ^a   Roxas Duncan, Virginia ^b   Dakshanamurthy, Sivanesan ^c   Smith, Leonard A ^b   Yang, David C H ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

Botulinum; Fluorescence titration; Inhibitor; Molecular modeling; Neurotoxin; Peptide; Quinolinol; Slow binding; Tight binding; Zinc protease

Indexed keywords

7 [(2 BROMOANILINO)(PHENYL)METHYL] 8 QUINOLINOL; 7 [(4 CHLOROANILINO)(PHENYL)METHYL] 8 QUINOLINOL; 7 [[4 [HYDROXY(OXIDO)AMINO]ANILINO](PHENYL)METHYL] 8 QUINOLINOL; 7 [PHENYL (8 QUINOLINYLAMINO)METHYL] 8 QUINOLINOL; 8 QUINOLINOL DERIVATIVE; BOTULINUM TOXIN A; C PEPTIDE; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; NSC 1010; NSC 84086; NSC 84090; NSC 84096; PEPTIDE C1; PROTEINASE; PROTEINASE INHIBITOR; QUINOLINOL DERIVATIVE; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; UNCLASSIFIED DRUG; ZINC ION; ZINC PROTEASE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHELATION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; LIGHT CHAIN; MOLECULAR MODEL; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; TEMPERATURE DEPENDENCE;

AMINO ACID SEQUENCE; AMINOQUINOLINES; BOTULINUM TOXINS, TYPE A; CATALYTIC DOMAIN; CHELATING AGENTS; HYDROGEN-ION CONCENTRATION; HYDROXYQUINOLINES; KINETICS; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; TEMPERATURE; ZINC;

EID: 70350343490     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2009.09.008     Document Type: Article

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