Biologically active novel conformational state of botulinum, the most poisonous poison

Journal of Biological Chemistry

Volumn 280, Issue 47, 2005, Pages 39346-39352

  Kukreja, Roshan ^a   Singh, BalRam ^a  

^a UNIVERSITY OF MASSACHUSETTS DARTMOUTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; ENZYMES; MUSCLE; NEUROLOGY; PHYSIOLOGY;

BOTULINUM NEUROTOXIN; BOTULINUM NEUROTOXINS (SEROTYPES A-G); FLACCID MUSCLE PARALYSIS; INTRACELLULAR SUBSTRATE; OPTIMAL ENZYME ACTIVITY; PRE-IMMINENT MOLTEN-GLOBULE ENZYME; SNAP-25 (SYNAPTOSOMAL ASSOCIATED PROTEIN OF 25 KDA); SNARE PROTEINS OF PRESYNAPTIC EXOCYTOSIS MACHINERY;

TOXIC MATERIALS;

8 ANILINO 1 NAPHTHALENESULFONIC ACID; ANTIDOTE; BOTULINUM TOXIN A; POISON; POLYPEPTIDE; PROTEINASE; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; TRYPTOPHAN;

ARTICLE; BOTULISM; CIRCULAR DICHROISM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME CONFORMATION; FLACCID PARALYSIS; FLUORESCENCE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; TEMPERATURE; ULTRAVIOLET SPECTROSCOPY;

BOTULINUM TOXIN TYPE A; CIRCULAR DICHROISM; ENDOPEPTIDASES; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; TEMPERATURE;

EID: 28244483285     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M508463200     Document Type: Article

References (49)

1. Schiavo, G., Matteoli, M., and Montecucco, C. (2000) Physiol. Rev. 80, 717-755
2. Ergbuth, F. J. (2004) Movement Disorders 19, S2-S6
3. Arnon, S. S., Schechter, R., Ingelsby, T. V., Henderson, D. A., Bartlett, D. A., Ascher, M. S., Eitzen, E., Fine, A. D., Hauer, J., Layton, M., Lillibridge, S., Osterholm, M. T., O'Toole, T., Parker, G., Perl, T. M., Russell, P. K., Swerdlow, D. L., and Tonat, K, (2001) J. Am. Med. Assoc. 285, 1059-1070
4. Wheeler, A. H. (1997) Am. Fam. Physician 55, 541-545, 548
5. Klein, A. W. (2004) Dermatol. Surg. 30, 452-455
6. Cordivari, C., Misra, P. V., Catania, S., and Lees, A. J. (2004) Movement Disorders 19, 157-161
7. Singh, B. R. (2000) Nat. Struct. Biol. 7, 617-619
8. Hooper, N. H. (1994) FEBS Lett. 354, 1-6
9. Vallee, B. L., and Auld, D. S. (1990) Biochemistry 29, 5647-5659
10. Schiavo, G., Santucci, A., DasGupta, B. R., Mehta, P. P., Jontes, J., Benfenati, F., Wilson, M. C., and Montecucco, C. (1993) FEBS Lett. 335, 99-103
11. Schiavo, G., Benfenati, F., Poulain, B., Rossetto, O., Polverino de Laureto, P., DasGupta, B. R., and Montecucco, C. (1992) Nature 359, 832-835
12. Schiavo, G., Shone, C. C., Benett, M. K., Scheller, R. H., and Montecucco, C. (1995) J. Biol. Chem. 270, 10566-10570
13. Eswaramoorthy, S., Kumaran, D., and Swaminathan, S. (2002) Biochemistry 41, 9795-9802
14. Agarwal, R., Eswaramoorthy, S., Kumaran, D., Binz, T., and Swaminathan, S. (2004) Biochemistry 43, 637-6644
15. Segelke, B., Knapp, M., Kadkhodayan, S., Balhorn, R., and Rupp, B. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 6888-6893
16. Breidenbach, M. A., and Brunger, A. T. (2004) Nature 432, 925-929
17. Lacy, D. B., Tepp, W., Cohen, A. C., DasGupta, B. R., and Stevens, R. C. (1998) Nat. Struct. Biol. 5, 898-902
18. Swaminathan, S., and Eswaramoorthy, S. (2000) Nat. Struct. Biol. 7, 693-699
19. Lacy, D. B., and Stevens, R. C. (1999) J. Mol. Biol. 291, 1091-1104
20. Singh, B. R. (2002) in Scientific and Therapeutic Aspects of Botulinum Toxin (Brin, M. F., Jankovic, J., and Hallet, M., eds) pp. 75-88, Lippincott Williams and Wilkins, Philadelphia
21. Cai, S., and Singh, B. R. (2001) Biochemistry 40, 4693-4702
22. Cai, S., and Singh, B. R. (2001) Biochemistry 50, 15327-15333
23. Li, L., and Singh, B. R. (1999) Protein Expression Purif. 17, 339-344
24. Ragone, R., Colonna, G., Balestrieri, C., Servillo, L., and Irace, G. (1984) Biochemistry 23, 1871-1875
25. Singh, B. R., and DasGupta, B. R. (1989) Mol. Cell. Biochem. 85, 67-73
26. Ohgushi, M., and Wada, A. (1983) FEBS Lett. 164, 21-24
27. Deshpande, S. S., and Damodaran, S. (1989) Biochim. Biophys, Acta 998, 179-188
28. Semisotnov, G. V., Rodionova, N. A., Razgulyaev, O. I., Uversky, V. N., Gripas, A. F., and Gilmanshin, R. I. (1991) Biopolymers 31, 119-128
29. Ptitsyn, O. B. (1995) Adv. Protein. Chem. 47, 83-229
30. Singh, B. R., Wasacz, F. M., Strand, S., Jacobsen, R. J., and DasGupta, B. R. (1990) J. Protein Chem. 9, 705-713
31. Singh, B. R., and DasGupta, B. R. (1989) Biophys. Chem. 34, 259-267
32. France, R. M., and Grossman, S. H. (2000) Biochem. Biophys. Res. Comm. 269, 709-712
33. Eftink, M. R., and Ghiron, C. A. (1975) Proc. Natl. Acad. Sci. U. S. A. 72, 3290-3294
34. Demchenko, A. P. (1986) Essays Biochem. 22, 120-157
35. Eftink, M. R., and Ghiron, C. A. (1976) Biochemistry 15, 672-680
36. Eftink, M. R., and Ghiron, C. A. (1977) Biochemistry 16, 5546-5551
37. Li, L., and Singh, B. R. (2000) Biochemistry 39, 6466-6474
38. Dubey, V. K., and Jagannadham, M. V. (2003) Biochemistry 42, 12287-12297
39. Washbourne, P., Pellizari, R., Baldini, G., Wilson, M. C., and Montecucco, C. (1997) FEBS Lett. 418, 1-5
40. Vaidyanathan, V. V., Yoshino, K., Jahnz, M., Dorries, C., Bade, S., Nauenburg, S., Niemann, H., and Binz, T. (1993) J. Neurochem. 72, 327-337
41. Betz, S. F., Raleigh, D. P., and DeGrado, W. F. Curr. (1999) Curr. Opin. Struct. Biol. 3, 601-610
42. Vamvaca, K., Vogeli, B., Kast, P., Pervushin, K., and Hilvert, D. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 12860-12864
43. Bryson, J. W., Betz, S. F., Lu, H. S., Suich, D. J., Zhou, H. X., O'Neil, K. T., and DeGrado, W. F. (1995) Science 270, 935-941
44. Bychkova, V. E., and Ptitisyn, O. B. (1993) Chem. Bio. and Mol. Biol. 4, 133-163
45. Ara, M., and Kuwajima, K. (2000) Adv. Protein Chem. 53, 209-282
46. van der Goot, F. G., Gonzalez-Manas, J. M., Lakey, J. H., and Pattus, F. (1991) Nature 354, 408-410
47. Bychkova, V. E., Pain, R. H., and Ptitsyn, O. B. (1988) FEBS Lett. 238, 231-234
48. Nakagawa, S. H., and Tager, H. S. (1993) Biochemistry 32, 7237-7243
49. Martin, J., Langer, T., Boteva, R., Schramel, A., Horwich, A., and Hartl, F. (1991) Nature 352, 36-42.