Inactivation of staphylococcal virulence factors using a light-activated antimicrobial agent

BMC Microbiology

Volumn 9, Issue , 2009, Pages

  Tubby, Sarah ^a   Wilson, Michael ^a   Nair, Sean P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA HEMOLYSIN; BACTERIAL ENZYME; METHYLENE BLUE; PROTEASE V8; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; PHOTOSENSITIZING AGENT; VIRULENCE FACTOR;

ARTICLE; BACTERIAL VIRULENCE; DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; LASER; NONHUMAN; PHOTOSENSITIZATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEGRADATION; RADIATION EXPOSURE; STAPHYLOCOCCUS AUREUS; ANIMAL; C57BL MOUSE; FEMALE; HEAT; LIGHT; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGICAL EXAMINATION; MOUSE; PHOTOCHEMOTHERAPY; STAPHYLOCOCCUS INFECTION; TEMPERATURE; WOUND INFECTION;

STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; FEMALE; HOT TEMPERATURE; LIGHT; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; METHYLENE BLUE; MICE; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; STAPHYLOCOCCAL INFECTIONS; TEMPERATURE; VIRULENCE FACTORS; WOUND INFECTION;

EID: 70350340057     PISSN: 14712180     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-9-211     Document Type: Article

References (32)

1. Commensals upon us. MN Alekshun SB Levy, Biochem Pharmacol 2006 71 7 893 900 10.1016/j.bcp.2005.12.040 16464437
2. The clinical significance of methicillin-resistant Staphylococcus aureus. IM Gould, J Hosp Infect 2005 61 4 277 282 10.1016/j.jhin.2005.06.014 16216384
3. Staphylococci. AL Casey PA Lambert TSJ Elliott, Int J Antimicrob Agents 2007 29 Supplement 3 23 S32 10.1016/S0924-8579(07)72175-1 17659209
4. Surveillance of healthcare associated infections report: 2008. Health Protection Agency, London: Health Protection Agency 2008
5. Staphylococcus aureus infections. FD Lowy, N Engl J Med 1998 339 8 520 532 10.1056/NEJM199808203390806 9709046
6. Community-acquired methicillin-resistant Staphylococcus aureus. DM Elston, J Am Acad Dermatol 2007 56 1 1 16 10.1016/j.jaad.2006.04.018 17190619
7. The Staphylococcus aureus "superbug". TJ Foster, J Clin Invest 2004 114 12 1693 1696 15599392
8. Costs of hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) and its control. IM Gould, Int J Antimicrob Agents 2006 28 5 379 384 10.1016/j.ijantimicag.2006.09.001 17045462
9. Regulation of virulence determinants in Staphylococcus aureus. S Arvidson K Tegmark, Int J Med Microbiol 2001 291 2 159 170 10.1078/1438-4221-00112 11437338
10. Exotoxins of Staphylococcus aureus. MM Dinges PM Orwin PM Schlievert, Clin Microbiol Rev 2000 13 1 16 34 10.1128/CMR.13.1.16-34.2000 10627489
11. Are bacterial proteinases pathogenic factors? J Travis J Potempa H Maeda, Trends Microbiol 1995 3 10 405 407 10.1016/S0966-842X(00)88988-X 8564361
12. The development of phenothiazinium photosensitisers. M Wainwright, Photodiag Photodyn Ther 2005 2 4 263 10.1016/S1572-1000(05)00110-9
13. Photodynamic therapy: a new antimicrobial approach to infectious disease? MR Hamblin T Hasan, Photochem Photobiol Sci 2004 3 5 436 450 10.1039/b311900a 15122361
14. The effect of photodynamic action on two virulence factors of gram-negative bacteria. N Komerik M Wilson S Poole, Photochem Photobiol 2000 72 5 676 680 10.1562/0031-8655(2000)072<0676:TEOPAO2.0.CO;2 11107854
15. Inactivation of proteolytic enzymes from Porphyromonas gingivalis using light-activated agents. S Packer M Bhatti T Burns M Wilson, Lasers Med Sci 2000 15 1 24 30 10.1007/s101030050043
16. Methylene blue derivatives - suitable photoantimicrobials for blood product disinfection? M Wainwright, Int J Antimicrob Agents 2000 16 4 381 394 10.1016/S0924-8579(00)00207-7 11118846
17. Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. CD Sifri J Begun FM Ausubel SB Calderwood, Infect Immun 2003 71 4 2208 2217 10.1128/IAI.71.4.2208-2217.2003 12654843
18. The role and regulation of the extracellular proteases of Staphylococcus aureus. L Shaw E Golonka J Potempa SJ Foster, Microbiology 2004 150 1 217 228 10.1099/mic.0.26634-0 14702415
19. Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis. AL Cheung KJ Eberhardt E Chung MR Yeaman PM Sullam M Ramos AS Bayer, J Clin Invest 1994 94 5 1815 1822 10.1172/JCI117530 7962526
20. Proteolytic activity of Staphylococcus aureus strains isolated from the colonized skin of patients with acute-phase atopic dermatitis. J Miedzobrodzki P Kaszycki A Bialecka A Kasprowicz, Eur J Clin Microbiol Infect Dis 2002 21 4 269 276 10.1007/s10096-002-0706-4 12072937
21. Oral psoralen photochemotherapy of atopic eczema. WL Morison JA Parrish TB Fitzpatrick, Br J Dermatol 1978 98 1 25 30 10.1111/j.1365-2133.1978.tb07329.x 626712
22. Staphylococcus aureus [alpha]-toxin-induced cell death: predominant necrosis despite apoptotic caspase activation. F Essmann H Bantel G Totzke IH Engels B Sinha K Schulze-Osthoff RU Janicke, Cell Death Differ 2003 10 11 1260 1272 10.1038/sj.cdd.4401301 12894214
23. Virulence of Staphylococcus aureus in a mouse mastitis model: studies of alpha hemolysin, coagulase, and protein A as possible virulence determinants with protoplast fusion and gene cloning. P Jonsson M Lindberg I Haraldsson T Wadstrom, Infect Immun 1985 49 3 765 769 4040889
24. Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. JB Wardenburg T Bae M Otto FR Deleo O Schneewind, Nat Med 2007 13 12 1405 1406 10.1038/nm1207-1405 18064027
25. Effects of Staphylococcus aureus-hemolysin A on calcium signalling in immortalized human airway epithelial cells. S Eichstaedt K Gabler S Below C Muller C Kohler S Engelmann P Hildebrandt U Volker M Hecker JP Hildebrandt, Cell Calcium 2009 45 2 165 176 10.1016/j.ceca.2008.09.001 18922576
26. Alpha-toxin of Staphylococcus aureus. S Bhakdi J Tranum-Jensen, Microbiol Mol Biol Rev 1991 55 4 733 751
27. Sphingomyelinase activity of Staphylococcus aureus strains from recurrent furunculosis and other infections. SA Hedström T Malmqvist, Acta Pathol Microbiol Immunol Scand [B] 1982 90 3 217 220 6289601
28. Structure and biological activities of beta toxin from Staphylococcus aureus. M Huseby K Shi CK Brown J Digre F Mengistu KS Seo GA Bohach PM Schlievert DH Ohlendorf CA Earhart, J Bacteriol 2007 189 23 8719 8726 10.1128/JB.00741-07 17873030
29. Effect of albumin on the photodynamic inactivation of microorganisms by a cationic porphyrin. SA Lambrechts MC Aalders FD Verbraak JW Lagerberg JB Dankert JJ Schuitmaker, J Photochem Photobiol B 2005 79 51 57 10.1016/j.jphotobiol.2004.11.020 15792879
30. Correlation between toxin binding and hemolytic activity in membrane damage by staphylococcal alpha-toxin. S Bhakdi M Muhly R Fussle, Infect Immun 1984 46 2 318 323 6500692
31. A spectrophotometric method for determination of sphingomyelinase. S Gatt T Dinur Y Barenholz, Biochim Biophys Acta 1978 530 3 503 507 212111
32. Selective killing of human monocytes and cytokine release provoked by sphingomyelinase (beta-toxin) of Staphylococcus aureus. I Walev U Weller S Strauch T Foster S Bhakdi, Infect Immun 1996 64 8 2974 2979 8757823