Molecular properties and CYP2D6 substrates: Central nervous system therapeutics case study and pattern analysis of a substrate database

Drug Metabolism and Disposition

Volumn 37, Issue 11, 2009, Pages 2204-2211

  Chico, Laura K ^a   Behanna, Heather A ^a,c   Hu, Wenhui ^b   Zhong, Guifa ^b   Roy, Saktimayee Mitra ^a   Watterson, D Martin ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^c ASTELLAS PHARMA GLOBAL DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 4 METHYL 6 PHENYLPYRIDAZINE; 4 METHYL 6 PHENYL 3 (4 (PYRIDIN 3 YL)PIPERAZIN 1 YL)PYRIDAZINE; 4 METHYL 6 PHENYL N (2 (PIPERAZIN 1 YL)ETHYL)PYRIDAZIN 3 AMINE; 4 METHYL 6 PHENYL N (2 (PIPERIDIN 1 YL)ETHYL)PYRIDAZIN 3 AMINE; 4 METHYL 6 PHENYLN (2 (TETRAHYDRO 2H PYRAN 4 YL)ETHYL)PYRIDAZIN 3 AMINE; CENTRAL NERVOUS SYSTEM AGENTS; CYTOCHROME P450 2D6; MINAPRINE; MINOZAC; N (2 MORPHOLINOETHYL) 6 PHENYLPYRIDAZIN 3 AMINE; N 1,N 2 DIMETHY N 1 (4 METHYL 6 PHENYLPYRIDAZIN 3 YL) N 2 (PYRIMIDIN 2 YL)ETHANE 1,2 DIAMINE; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SUBSTITUTION; DRUG SYNTHESIS; ENZYME KINETICS; PRIORITY JOURNAL;

CASE-CONTROL STUDIES; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DISEASES; CYTOCHROME P-450 CYP2D6; DATABASES, FACTUAL; PYRIDAZINES; STATISTICS AS TOPIC; SUBSTRATE SPECIFICITY;

EID: 70350330872     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.028134     Document Type: Article

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