Insertional mutations in herpes simplex virus type 1 gL identify functional domains for association with gh and for membrane fusion

Journal of Virology

Volumn 83, Issue 22, 2009, Pages 11607-11615

  Fan, Qing ^a   Lin, Erick ^a,b   Spear, Patricia G ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; GLYCOPROTEIN; GLYCOPROTEIN H; GLYCOPROTEIN L; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY DETECTION; ARTICLE; CELL FUSION; CELL SURFACE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE INSERTION; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; IMMUNOPRECIPITATION; MEMBRANE FUSION; MUTATIONAL ANALYSIS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; VIRION; VIRUS ENTRY; VIRUS INFECTIVITY; VIRUS VIRULENCE; WESTERN BLOTTING;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DIMERIZATION; HERPESVIRUS 1, HUMAN; MUTAGENESIS, INSERTIONAL; PROTEIN STRUCTURE, TERTIARY; VIRAL ENVELOPE PROTEINS; VIRUS INTEGRATION; VIRUS INTERNALIZATION;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 70350328586     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01369-09     Document Type: Article

References (36)

1. Cairns, T. M., D. J. Landsburg, J. Charles Whitbeck, R. J. Eisenberg, and G. H. Cohen. 2005. Contribution of cysteine residues to the structure and function of herpes simplex virus gH/gL. Virology 332:550-562.
2. Dubin, G., and H. Jiang. 1995. Expression of herpes simplex virus type 1 glycoprotein L (gL) in transfected mammalian cells: Evidence that gL is not independently anchored to cell membranes. J. Virol. 69:4564-4568.
3. Galdiero, M., A. Whiteley, B. Bruun, S. Bell, T. Minson, and H. Browne. 1997. Site-directed and linker insertion mutagenesis of herpes simplex virus type 1 glycoprotein H. J. Virol. 71:2163-2170. (Pubitemid 27078596)
4. Galdiero, S., A. Falanga, M. Vitiello, H. Browne, C. Pedone, and M. Galdiero. 2005. Fusogenic domains in herpes simplex virus type 1 glycoprotein H. J. Biol. Chem. 280:28632-28643.
5. Galdiero, S., A. Falanga, M. Vitiello, M. D'Isanto, M. Cantisani, A. Kampanaraki, E. Benedetti, H. Browne, and M. Galdiero. 2008. Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity. Peptides 29:1461-1471.
6. Galdiero, S., M. Vitiello, M. D'Isanto, A. Falanga, C. Collins, K. Raieta, C. Pedone, H. Browne, and M. Galdiero. 2006. Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and B. J. Gen. Virol. 87:1085-1097.
7. Geraghty, R. J., C. Krummenacher, G. H. Cohen, R. J. Eisenberg, and P. G. Spear. 1998. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 280:1618-1620.
8. Gianni, T., R. Fato, C. Bergamini, G. Lenaz, and G. Campadelli-Fiume. 2006. Hydrophobic α-helices 1 and 2 of herpes simplex virus gH interact with lipids, and their mimetic peptides enhance virus infection and fusion. J. Virol. 80:8190-8198. (Pubitemid 44182319)
9. Gianni, T., P. L. Martelli, R. Casadio, and G. Campadelli-Fiume. 2005. The ectodomain of herpes simplex virus glycoprotein H contains a membrane α-helix with attributes of an internal fusion peptide, positionally conserved in the Herpesviridae family. J. Virol. 79:2931-2940. (Pubitemid 40270571)
10. Gianni, T., L. Menotti, and G. Campadelli-Fiume. 2005. A heptad repeat in herpes simplex virus 1 gH, located downstream of the α-helix with attributes of a fusion peptide, is critical for virus entry and fusion. J. Virol. 79:7042-7049. (Pubitemid 40677335)
11. Gianni, T., A. Piccoli, C. Bertucci, and G. Campadelli-Fiume. 2006. Heptad repeat 2 in herpes simplex virus 1 gH interacts with heptad repeat 1 and is critical for virus entry and fusion. J. Virol. 80:2216-2224. (Pubitemid 43271528)
12. Gompels, U. A., and A. C. Minson. 1989. Antigenic properties and cellular localization of herpes simplex virus glycoprotein H synthesized in a mammalian cell expression system. J. Virol. 63:4744-4755.
13. Heldwein, E. E., H. Lou, F. C. Bender, G. H. Cohen, R. J. Eisenberg, and S. C. Harrison. 2006. Crystal structure of glycoprotein B from herpes simplex virus 1. Science 313:217-220. (Pubitemid 44066251)
14. Huber, M. T., and T. Compton. 1998. The human cytomegalovirus UL74 gene encodes the third component of the glycoprotein H-glycoprotein L-containing envelope complex. J. Virol. 72:8191-8197.
15. Hutchinson, L., H. Browne, V. Wargent, N. Davis-Poynter, S. Primorac, K. Goldsmith, A. C. Minson, and D. C. Johnson. 1992. A novel herpes simplex virus glycoprotein, gL, forms a complex with glycoprotein H (gH) and affects normal folding and surface expression of gH. J. Virol. 66: 2240-2250.
16. Klyachkin, Y. M., and R. J. Geraghty. 2008. Mutagenic analysis of herpes simplex virus type 1 glycoprotein L reveals the importance of an arginine-rich region for function. Virology 374:23-32.
17. Klyachkin, Y. M., K. D. Stoops, and R. J. Geraghty. 2006. Herpes simplex virus type 1 glycoprotein L mutants that fail to promote trafficking of glycoprotein H and fail to function in fusion can induce binding of glycoprotein L-dependent anti-glycoprotein H antibodies. J. Gen. Virol. 87:759-767.
18. Li, Q., S. M. Turk, and L. M. Hutt-Fletcher. 1995. The Epstein-Barr virus (EBV) BZLF2 gene product associates with the gH and gL homologs of EBV and carries an epitope critical to infection of B cells but not of epithelial cells. J. Virol. 69:3987-3994.
19. Lin, E., and P. G. Spear. 2007. Random linker-insertion mutagenesis to identify functional domains of herpes simplex virus type 1 glycoprotein B. Proc. Natl. Acad. Sci. USA 104:13140-13145.
20. Montgomery, R. I., M. S. Warner, B. J. Lum, and P. G. Spear. 1996. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/ NGF receptor family. Cell 87:427-436.
21. Novotny, M. J., M. L. Parish, and P. G. Spear. 1996. Variability of herpes simplex virus 1 gL and anti-gL antibodies that inhibit cell fusion but not viral infectivity. Virology 221:1-13.
22. Parry, C., S. Bell, T. Minson, and H. Browne. 2005. Herpes simplex virus type 1 glycoprotein H binds to αvβ3 integrins. J. Gen. Virol. 86:7-10.
23. Peng, T., M. Ponce de Leon, M. J. Novotny, H. Jiang, J. D. Lambris, G. Dubin, P. G. Spear, G. H. Cohen, and R. J. Eisenberg. 1998. Structural and antigenic analysis of a truncated form of herpes simplex virus glycoprotein gH-gL complex. J. Virol. 72:6092-6103. (Pubitemid 28283399)
24. Pertel, P., A. Fridberg, M. L. Parish, and P. G. Spear. 2001. Cell fusion induced by herpes simplex virus glycoproteins gB, gD, and gH-gL requires a gD receptor but not necessarily heparan sulfate. Virology 279:313-324. (Pubitemid 34161021)
25. Plate, A. E., J. Smajlovic, T. S. Jardetzky, and R. Longnecker. 2009. Functional analysis of glycoprotein L from rhesus lymphocryptovirus in Epstein- Barr virus-mediated cell fusion indicates a direct role of gL in gB-induced membrane fusion. J. Virol. doi:10.1128/JVI.00457-09.
26. Roop, C., L. Hutchinson, and D. C. Johnson. 1993. A mutant herpes simplex virus type 1 unable to express glycoprotein L cannot enter cells, and its particles lack glycoprotein H. J. Virol. 67:2285-2297. (Pubitemid 23088405)
27. Satoh, T., J. Arii, T. Suenaga, J. Wang, A. Kogure, J. Uehori, N. Arase, I. Shiratori, S. Tanaka, Y. Kawaguchi, P. G. Spear, L. L. Lanier, and H. Arase. 2008. PILRa is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell 132:935-944.
28. Showalter, S. D., M. Zweig, and B. Hampar. 1981. Monoclonal antibodies to herpes simplex virus type 1 proteins, including the immediate-early protein ICP 4. Infect. Immun. 34:684-692.
29. Shukla, D., and P. G. Spear. 2001. Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry. J. Clin. Investig. 108:503-510.
30. Spear, P. G. 2004. Herpes simplex virus: receptors and ligands for cell entry. Cell. Microbiol. 6:401-410.
31. Spear, P. G., R. J. Eisenberg, and G. H. Cohen. 2000. Three classes of cell surface receptors for alphaherpesvirus entry. Virology 275:1-8.
32. Subramanian, R. P., and R. J. Geraghty. 2007. Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate by sequential activity of glycoproteins D, H, L, and B. Proc. Natl. Acad. Sci. USA 104: 2903-2908.
33. Turner, A., B. Bruun, T. Minson, and H. Browne. 1998. Glycoproteins gB, gD and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system. J. Virol. 72:873-875. (Pubitemid 28048916)
34. Wang, D., and T. Shenk. 2005. Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism. Proc. Natl. Acad. Sci. USA 102:18153-18158.
35. Wang, X., W. J. Kenyon, Q. Li, J. Mullberg, and L. M. Hutt-Fletcher. 1998. Epstein-Barr virus uses different complexes of glycoproteins gH and gL to infect B lymphocytes and epithelial cells. J. Virol. 72:5552-5558. (Pubitemid 28283338)
36. Wyrwicz, L. S., and L. Rychlewski. 2007. Herpes glycoprotein gL is distantly related to chemokine receptor ligands. Antivir. Res. 75:83-86.