Cell fusion induced by herpes simplex virus glycoproteins gB, gD, and gH-gL requires a gD receptor but not necessarily heparan sulfate

Virology

Volumn 279, Issue 1, 2001, Pages 313-324

  Pertel, Peter E ^a   Fridberg, Alina ^a   Parish, Mary L ^a   Spear, Patricia G ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GB; GLYCOPROTEIN GD; GLYCOPROTEIN GH; GLYCOPROTEIN GI; GLYCOPROTEIN GJ; GLYCOPROTEIN GK; GLYCOPROTEIN GL; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS RECEPTOR;

ADSORPTION KINETICS; ANIMAL CELL; ARTICLE; CELL FUSION; CELL SURFACE; CONTROLLED STUDY; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; VIRUS ADSORPTION; VIRUS CELL INTERACTION;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 0035915995     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0713     Document Type: Article

References (71)

1. Characterization of a herpes simplex virus type 1 mutant which has a temperature-sensitive defect in penetration of cells and assembly of capsids
2. Mouse homolog of poliovirus receptor-related gene 2 product, mPRR2, mediates homophilic cell aggregation
3. L20 gene of herpes simplex virus 1 encodes a function necessary for viral egress
4. Fine structure physical map locations of alterations that affect cell fusion in herpes simplex virus type 1
5. Nucleotide sequence of a region of the herpes simplex virus type 1 gB glycoprotein gene: Mutations affecting rate of virus entry and cell fusion
6. Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion
7. The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells
8. Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, nectin1 (PRR1/HveC/HIgR), and nectin2 (PRR2/HveB)
9. Analysis of the contributions of herpes simplex virus type 1 membrane proteins to the induction of cell-cell fusion
10. Nucleotide sequence of a herpes simplex virus type 1 gene that causes cell fusion
11. Nucleotide sequences of herpes simplex virus type 1 (HSV-1) affecting virus entry, cell fusion, and production of glycoprotein gB (VP7)
12. Syncytial mutations in the herpes simplex virus type 1 gK (UL53) gene occur in two distinct domains
13. Two novel single amino acid syncytial mutations in the carboxy terminus of glycoprotein B of herpes simplex virus type 1 confer a unique pathogenic phenotype
14. Animal cell mutants defective in glycosaminoglycan biosynthesis
15. Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted
16. Syncytium-inducing mutations localize to two discrete regions within the cytoplasmic domain of herpes simplex virus type 1 glycoprotein B
17. Cellular expression of alphaherpesvirus gD interferes with entry of homologous and heterologous alphaherpesviruses by blocking access to a shared gD receptor
18. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
19. Herpes simplex virus infection and propagation in a mouse L cell mutant lacking heparan sulfate proteoglycans
20. The UL45 gene product is required for herpes simplex virus type 1 glycoprotein B-induced cell fusion
21. Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B
22. Glycoprotein C of herpes simplex virus type 1 plays a principal role in the absorption of virus to cells and in infectivity
23. A novel herpes simplex virus glycoprotein, gL, forms a complex with glycoprotein H (gH) and affects normal folding and surface expression of gH
24. Identification and characterization of a novel herpes simplex virus glycoprotein, gK, involved in cell fusion
25. Fine mapping of antigenic site II of herpes simplex virus glycoprotein D
26. A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture
27. Pseudorabies virus glycoprotein M inhibits membrane fusion
28. Neuraminidase hemadsorption activity, conserved in avian influenza A viruses, does not nfluence viral replication in ducks
29. Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpes virus entry mediator, two structurally unrelated mediators of virus entry
30. A herpes simplex virus mutant in which glycoprotein D sequences are replaced by β-galactosidase sequences binds to but is unable to penetrate into cells
31. The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule
32. Nectin2α (PRR2α or HveB), and nectin2δ are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D
33. Cell fusion induced by herpes simplex virus is promoted and suppressed by different viral glycoproteins
34. The murine homolog of human nectin1δ serves as a species nonspecific mediator for entry of human and animal αherpesviruses in a pathway independent of a detectable binding to gD
35. Aujeszky's disease (pseudorabies) virus: The virus and molecular pathogenesis - State of the art, June 1999
36. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family
37. Characterization of cell-cell fusion mediated by herpes simplex virus 2 glycoproteins gB, gD, gH, and gL in transfected cells
38. Monoclonal antibodies to distinct sites on herpes simplex virus (HSV) glycoprotein D block HSV binding to HVEM
39. Efficient selection for high-expression transfectants with a novel eukaryotic vector
40. Variability of herpes simplex virus 1 gL and anti-gL antibodies that inhibit cell fusion but not viral infectivity
41. Host range of human T-cell leukemia virus type 1 analyzed by a cell fusion-dependent reporter gene activation assay
42. Pseudorabies virus envelope glycoproteins gp50 and gII are essential for virus penetration, but only gII is involved in membrane fusion
43. Modified entry and syncytium formation by herpes simplex virus type 1 mutants selected for resistance to heparin inhibition
44. Partial resistance to gD-mediated interference conferred by mutations affecting herpes simplex virus type 1 gC and gK
45. The single base pair substitution responsible for the Syn phenotype of herpes simplex virus type 1, strain MP
46. Pseudorabies virus glycoproteins gII and gp50 are essential for virus penetration
47. A mutant herpes simplex virus type 1 unable to express glycoprotein L cannot enter cells, and its particles lack glycoprotein H
48. Molecular genetics of herpes simplex virus. II. Mapping of the major viral glycoproteins and of the genetic loci specifying the social behavior of infected cells
49. Thymidine kinase deletion mutants of herpes simplex virus type 1
50. Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic, and heterophilic cell-cell adhesion activities
51. Adaptability in herpesviruses: Glycoprotein D-independent infectivity of pseudorabies virus
52. Herpesvirus-induced cell fusion that is dependent on cell surface heparan sulfate or soluble heparin
53. Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans
54. Striking similarity of murine nectin-1α to human nectin-1α (HveC) in sequence and activity as a gD receptor for alphaherpesvirus entry
55. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry
56. The murine homolog (Mph) of human herpesvirus entry protein B (HveB) mediates entry of pseudorabies virus but not herpes simplex virus types 1 and 2
57. Membrane fusion induced by herpes simplex virus
58. Entry of alphaherpesviruses into cells
59. Three classes of cell surface receptors for alphaherpesvirus entry
60. Nectin/PRR: An immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with afadin, a PDZ domain-containing protein
61. Contributions of gD receptors and glycosaminoglycan sulfation to cell fusion mediated by herpes simplex virus 1
62. HveA (herpesvirus entry mediator A), a coreceptor for herpes simplex virus entry, also participates in virus-induced cell fusion
63. Modulation of firefly luciferase stability and impact on studies of gene regulation
64. Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system
65. The effect of heparin on herpes simplex virus
66. The HSV-1 UL45 gene product is not required for growth in Vero cells
67. A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus
68. Replacement of glycoprotein B gene sequences in herpes simplex virus type 1 strain ANG by corresponding sequences of the strain KOS causes changes in plaque morphology and neuropathogenicity
69. Glycoprotein D of herpes simplex virus binds directly to HVEM, a mediator of HSV entry
70. Initial interaction of herpes simplex virus with cells is binding to heparan sulfate