Review of drug treatment for female sexual dysfunction

International Journal of STD and AIDS

Volumn 20, Issue 10, 2009, Pages 671-674

  Wylie, K ^a   Malik, F ^a  

^a Porterbrook Clinic   (United Kingdom)

Author keywords

Arousal; Desire; Orgasm; Pain; Pharmacology; Women

Indexed keywords

AMFEBUTAMONE; ANDROGEN; ARGININE; BREMELANOTIDE; DOPAMINE RECEPTOR STIMULATING AGENT; ESTRADIOL; ESTROGEN; FLIBANSERIN; HERBACEOUS AGENT; MELANOCORTIN RECEPTOR AGONIST; NORETHISTERONE ACETATE; PHENTOLAMINE; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; PROGESTERONE; PROSTAGLANDIN; PROSTAGLANDIN E1; SILDENAFIL; TESTOSTERONE; TIBOLONE;

ACNE; ALOPECIA; CANCER RISK; CLINICAL TRIAL; CLITOTOMEGALY; DRUG ACTIVITY; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG MEGADOSE; ENDOMETRIUM CANCER; ENDOMETRIUM HYPERPLASIA; ERECTILE DYSFUNCTION; ESTROGEN THERAPY; FEMALE SEXUAL DYSFUNCTION; FLUSHING; GALLBLADDER DISEASE; GINKGO BILOBA; GINSENG; HIRSUTISM; HORMONAL THERAPY; HUMAN; HYPOACTIVE SEXUAL DESIRE DISORDER; LIBIDO; LIBIDO DISORDER; LIVER DISEASE; NAUSEA; ORGASM DISORDER; PRIORITY JOURNAL; PSYCHOTHERAPY; REVIEW; RHINITIS; SEX THERAPY; SEXUAL AROUSAL; SEXUAL AROUSAL DISORDER; SEXUAL FUNCTION; SEXUAL SATISFACTION; SIDE EFFECT; SKIN IRRITATION; UPPER RESPIRATORY TRACT INFECTION; VAGINA DISEASE; VAGINAL DRYNESS; VAGINITIS; VENOUS THROMBOEMBOLISM; VOICE CHANGE;

DOPAMINE AGONISTS; FEMALE; HORMONES; HUMANS; MELANOCORTINS; PIPERAZINES; PROSTAGLANDINS; PURINES; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; SULFONES; VASODILATOR AGENTS;

EID: 70350228392     PISSN: 09564624     EISSN: None     Source Type: Journal    
DOI: 10.1258/ijsa.2009.009206     Document Type: Review

References (46)

1. Berman JR. Physiology of female sexual function and dysfunction. Int J Impot Res 2005;17:S44-51
2. Goldmeier D, Leiblum SR. STIs and sexual dysfunction. Sex Transm Infect 2005;81:364
3. Brown AD, Blagg J, Reynolds DS. Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today 2007;12:757-766 (Pubitemid 47362785)
4. Basson R. Women's sexual dysfunction: revised and expanded definitions. CMAJ 2005;172:1327-1333 (Pubitemid 40745076)
5. Wylie K, Mimoun S. Sexual response models in women. Maturitas 2009; 63:112-115
6. Berman JR, et al. Female sexual dysfunction: anatomy, physiology, evaluation and treatment options. Curr Opin Urol 1999;9:563-568 (Pubitemid 30060207)
7. Butcher J. ABC of sexual health: female sexual problems II: sexual pain and sexual fears. BMJ 1999;318:110-112 (Pubitemid 29188930)
8. Kaplan C. Assessing and managing female sexual dysfunction. Nurse Pract 2009;34:42-48
9. Wylie KR. Sexuality. In: Pawson M, Cockburn J, eds. Psychological Challenges in Obstetrics and Gynecology. The Clinical Management. London: Springer, 2007
10. Wylie KR, Daines B, Jannini EA, et al. Loss of sexual desire in the postmenopausal woman. J Sex Med 2007;4:395-405 (Pubitemid 46394713)
11. Frank JR, Mistretta P, Will J. Diagnosis and treatment of female sexual dysfunction. Am Fam Physician 2008;77:635-642
12. Wierman ME. Sex steroid effects at target tissues: mechanisms of action. Adv Physiol Educ 2007;31:26-33
13. Hofland SL, Powers J. Sexual dysfunction in the menopausal woman: hormonal causes and management issues. Geriatr Nurs 1996;17:161-165
14. Castelo-Branco C, Cancelo MJ, Chedraui P. Female sexual dysfunction in postmenopausal women. Expert Opin Ther Patents 2007;17:1-10 (Pubitemid 47045527)
15. Gregerson N, Jensen PT, Giraldi AE. Sexual dysfunction in the peri- and postmenopause. Dan Med Bull 2006;53:349-353
16. Canonico M, Oger E, Plu-Bureau G, et al. Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: The ESTHER Study. Circulation 2007;115:840-845 (Pubitemid 46294724)
17. Barrett-Connor E, Grady D. Hormone replacement therapy, heart disease, and other considerations. Annu Rev Public Health 1998;19:55-72 (Pubitemid 28279924)
18. Arlt W. Androgen therapy in women. Eur J Endocrinol 2006;154:1-11
19. Mahmoud MS, Diamond MP, Balon R. Androgen therapy for low female libido. Sex, Reprod Menopause 2006;4:52-59 (Pubitemid 44429701)
20. Davison SL, Bell R, Donath S, Montalto JG, Davis SR. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab 2005;90:3847-3853 (Pubitemid 41058142)
21. Davis SR, Moreau M, Krou R, et al. Testosterone for low libido in postmenopausal women not taking estrogen. N Engl J Med 2008;359:2005-2017
22. Braunstein GD, Sundwall DA, Kratz M, et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Arch Intern Med 2005;165:1582-1589
23. Shufelt CL, Braunstein GD. Testosterone and the breast. Menopause Int 2008;14:117-122
24. Schover LR. Androgen therapy for loss of desire in women: is the benefit worth the breast cancer risk? Fertil Steril 2008;90:129-140
25. Simon J, Braunstein G, Nachtigall L, et al. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 2005;90:5226-5333 (Pubitemid 41262278)
26. Buvat J. Androgen therapy with dehydroepiandrosterone. World J Urol 2003;21:346-355
27. Nijland EA, Weijmar Schultz WC, Nathorst-Boös J, et al. LISA Study Investigators. Tibolone and transdermal E2/NETA for the treatment of female sexual dysfunction in naturally menopausal women: results of a randomized active-controlled trial. J Sex Med 2008;5:646-656
28. Goldstein I, Lue T, Padma-Nathan H, Rosen R, Steers W, Wicker P. Oral sildenafil in the treatment of erectile dysfunction: Sildenafil Study Group. N Engl J Med 1998;338:1397-1404
29. Ghofrani HA, Osterloh IH, Grimminger F. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov 2006;5:689-702 (Pubitemid 44151606)
30. Ca channels. FASEB J 2004;18:1382-1391
31. Berman J, Berman L, Toler S, Gill J, Haughie S. Safety and efficacy of sildenafil citrate for the treatment of female sexual arousal disorder: a double-blind, placebo controlled study. J Urol 2003;170:2333-2338 (Pubitemid 37413990)
32. Fulton CW. Female Sexual dysfunction. US Pharm 2006;10:57-64
33. Schoen C, Bachmann G. Sildenafil citrate for female sexual arousal disorder: a future possibility? Nat. Rev Urol 2009;6:216-222
34. Kielbasa LA, Daniel KL. Topical Alprostadil Treatment of female sexual arousal disorder. Ann Pharmacother 2006;40:1369-1376 (Pubitemid 44204968)
35. Rosen RC, Phillips NA, Gendrano NC III, Ferguson DM. Oral phentolamine and female sexual arousal disorder: a pilot study. J Sex Marital Ther 1999;25:137-144
36. Derzko C, Elliot S, Lam W. Management of sexual dysfunction in postmenopausal breast cancer patients taking adjuvant aromatase inhibitor therapy. Curr Oncol 2007:(Suppl. 1.)
37. Modell JG, May RS, Katholi CR. Effect of bupropion-SR on orgasmic dysfunction in nondepressed subjects: a pilot study. J Sex Marital Ther 2000;26:231-240
38. Masand PS, Keller Ashton A, Gupta S, Frank B. Sustained-release bupropion for selective serotonin reuptake inhibitor-induced sexual dysfunction: a randomized, double-blind, placebo-controlled, parallel-group study. Am J Psychiatry 2001;158:805-807 (Pubitemid 32429853)
39. Segraves RT, Clayton A, Croft H, Wolf A, Warnock J. Bupropion sustained release for the treatment of hypoactive sexual desire disorder in premenopausal women. J Clin Psychopharmacol 2004;24:339-342 (Pubitemid 38658043)
40. Gantz I, Fong TM. The melanocortin system. Am J Physiol Endocrinol Metab 2003;284:E468-74
41. Safarinejad MR. Evaluation of the safety and efficacy of bremelanotide, a melanocortin receptor agonist, in female subjects with arousal disorder: a double-blind placebo-controlled, fixed dose, randomized study. European Urology Supplements. J Sex Med 2008;5:887-897
42. Jolly E, Clayton A, Thorp J, Lewis-D'Agostino D, Wunderlich G, Lesko L. T09-P-05 Design of Phase III pivotal trials of flibanserin in female Hypoactive Sexual Desire Disorder (HSDD). Sexologies 2008;17(Supp. 1):S133-4
43. Brown AD, Blagg J, Reynolds DS. Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today 2007;12:757-766 (Pubitemid 47362785)
44. Castelo-Branco C, Cancelo MJ, Chedraui P. Female sexual dysfunction in postmenopausal women. Expert Opin Ther Patents 2007;17:1-10 (Pubitemid 47045527)
45. Krychman ML, Gubili MS, Pereira L, Holstein L, Cassileth B. Female sexual enhancers and neutraceuticals. Curr Sex Health Rep 2007;4:177-182
46. Rowland DL, Tai W. A Review of plant-derived and herbal approaches to the treatment of sexual dysfunctions. JSMT 2003;29:185-205 (Pubitemid 36526632)