Androgen therapy for low female libido

Sexuality, Reproduction and Menopause

Volumn 4, Issue 2, 2006, Pages 52-59

  Mahmoud, Mohamad S ^a   Diamond, Michael P ^b,c   Balon, Richard ^b  

^a OAKWOOD HOSPITAL AND MEDICAL CENTER   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANDROSTENEDIONE; CORTICOTROPIN; DIURETIC AGENT; ESTRADIOL; ESTROGEN; LUTEINIZING HORMONE; METHYLTESTOSTERONE; PLACEBO; PRASTERONE; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; TESTOSTERONE CIPIONATE; TESTOSTERONE ENANTATE; TESTOSTERONE PROPIONATE;

ACNE; ADRENAL DISEASE; ANDROGEN DEFICIENCY; ANDROGEN THERAPY; AROMATIZATION; CHOLESTATIC HEPATITIS; CLINICAL TRIAL; CLITORIS HYPERTROPHY; CONGESTIVE HEART FAILURE; DRUG ABSORPTION; DRUG EFFICACY; DRUG FATALITY; DRUG MEGADOSE; DRUG SAFETY; DRUG WITHDRAWAL; EDEMA; ENZYME ACTIVITY; ESTROGEN ACTIVITY; ESTROGEN DEFICIENCY; ESTROGEN THERAPY; FEMALE; HIRSUTISM; HORMONE ACTION; HUMAN; HYPERCALCEMIA; INJECTION PAIN; INTIMACY; JAUNDICE; LIBIDO DISORDER; LIVER ADENOMA; LIVER CELL CARCINOMA; LIVER TUMOR; LONG TERM CARE; MALE TYPE ALOPECIA; MENSTRUAL CYCLE; MENSTRUAL IRREGULARITY; NONHUMAN; OILY SKIN; ORGASM; OVARIECTOMY; PELIOSIS HEPATIS; POLYCYTHEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SEXUAL BEHAVIOR; SIDE EFFECT; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE METABOLISM; VAGINA DISEASE; VIRILIZATION; VOICE CHANGE;

EID: 33748938710     PISSN: 15462501     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sram.2006.08.006     Document Type: Review

References (43)

1. Basson R., Berman J., Burnett A., et al. Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol 183 (2000) 888-893
2. Masters E., and Johnson V. Human sexual response (1966), Little, Brown, Boston
3. Basson R. Women's sexual dysfunction: revised and expended definition. CMAJ 172 10 (2005) 1327-1333
4. Laumann E., Paik A., and Rosen R. Sexual dysfunction in the United States: prevalence and predictors. JAMA 281 (1999) 537-544
5. Sarrel P. Sexuality and menopause. Obstet Gyneol 7 5 (1990) 26S-30S
6. Semimons J., and Wagner G. Estrogen deprivation and vaginal function in postmenopausal women. JAMA 248 (1982) 445-448
7. Berman J., Berman L., Werbin T., et al. Clinical evaluation of female sexual function: effects of age and estrogen status on subjective and physiologic sexual responses. Int J Impotence Res 11 (1999) S31-S38
8. Shifrin J., Braunstein G., Simon J., et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 343 (2000) 682-688
9. Lobo R., Rosen C., Yang H., Block B., and van der Hoopp R. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 79 6 (2003) 1341-1352
10. Sherwin B., Gelfand M., and Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 47 (1985) 339-351
11. Langcope C. Adrenal and gonadal androgen secretion in normal females. Clin Endocrinol Metab 15 (1986) 213-227
12. Davison S., and Davis S. Androgens in women. Journal of steroid biochemistry and molecular biology 85 2003 (2003) 363-366
13. Vermeulen A., Verdonck L., and Kaufman J. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 83 10 (1999) 3666-3672
14. Abraham G. Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle. J Clin Endocrinol Metab 39 (1975) 340-346
15. Nappi R. Meanopause e sessualita (2002), CIC, Roma
16. Apperloo M., Van Der Stege J., Hoek A., and Weijmar Schultz W. In the mood for sex: the value of androgens. Journal of sex and marital therapy 29 2 (2003) 87-102
17. Vermeulen A. Plasma androgens in women. J Reprod Med 43 (1998) 725-733
18. Kennedy R., Davies T., and Al-azzawi F. Sexual interest in postmenopausal women is related to 5-alpha-reductase activity. Hum Reprod 12 (1997) 209-213
19. Mushayandebvu T., Castracane D., Gimbel T., Adel T., and Santoro N. Evidence for diminished mid-cycle ovarian androgen production in older reproductive aged women. Fertil Steril 65 (1996) 721-723
20. Mathur R., Landgreve S., Moody L., Semmens J., and Williamson H. The effect of estrogen treatment on plasma concentrations of steroid hormones, gonadotropins, prolactin and sex hormone-binding globulin in post-menopausal women. Maturitas 7 (1985) 129-133
21. Krug R., Psych D., Petrowsky R., Fehm H., and Born J. Selective influence of menstrual cycle on perception of stimuli with reproductive significance. Psychom Med 56 (1994) 410-417
22. Abraham G. Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle. J Clin Endocrinol Metab 39 (1974) 340-346
23. Shifren J. Androgen deficiency in the oophorectomized woman. Fertil Steril 77 S4 (2002) S60-S62
24. Rannevik G., Jeppsson S., Johnell O., Bjerre B., Laurell-Borulf Y., and Svanberg L. A Longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density. Maturitas 21 (1995) 103-113
25. Sherwin B. Changes in sexual behavior as a function of plasma sex steroid levels in post-menopausal women. Maturitas 7 (1985) 225-233
26. Laughlin G., Barrett-Connor E., Kritz-Silverstein D., and von Muhlen D. Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo Study. J Clin Endocrinol Metab 85 (2000) 645-651
27. Buster J., Kingsberg S., Aguirre O., Brown C., Breaux J., Buch A., Rodenberg C., Wekselman K., and Casson P. Testosterone Patch for Low Sexual Desire in Surgically Menopausal Women: A Randomized Trial. Obstet Gynecol 105 (2005) 944-952
28. Davis S. Androgen replacement in women: a commentary. J Clin Endocrinol Metab 84 (1999) 1886-1891
29. Greenblatt R. Androgenic therapy in women. J Clin Endocrinol Metab 2 (1942) 665-666
30. Davis S., Rees M., Ribot C., Moufarege A., Rodenberg C., and Purdie D. Efficacy and safety of testosterone patches for the treatment of low sexual desire in surgically menopausal women. Fertil Steril 80 suppl 3 (2003) S76 Abstract O-199.
31. Wiebke A., Hans-georg j., Frank C., Martin r., Doris H., Michael O., et al. Oral Dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression. J Clin Endocrinol Metab 8 6 (1998) 1928-1934
32. Lovas K., Gebre-Medhin G., Trovic T., et al. Replacement of dehydtroepiandrosterone in adrenal failure: no benefit for subjective health status and sexuality in a 9 month, randomized, parallel group clinical trial. J Clin Endocrinol Metab 88 3 (2003) 1112-1118
33. Hunt P., Gurnell E., Huppert F., et al. Improvement in mood and fatigue after Dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial. J Clin Endocrinol Metab 85 12 (2000) 4650-4656
34. Arlt W., Callies F., Van vlijmen J., et al. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 342 (1999) 1013-1020
35. Barrett-Connor E., Young R., Notelovitz M., Sullivan J., Wiita B., Yang H., and Nolan J. A two-year, double blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women. Effects on bone density, symptoms and lipid profiles. J Reprod Med 44 (1999) 1012-1020
36. Gitlin N., Korner P., and Yang H. Liver function in postmenopausal women on estrogen-androgen hormone replacement therapy: A meta-analysis of eight clinical trials. Menopause 6 (1999) 216-224
37. Davis S., McCloud P., Strauss B., and Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 21 (1995) 227-236
38. Rust J., and Gomlombok S. The GRISS: a psychometric instrument for the assessment of sexual dysfunction. Arch Sex Behav 15 (1986) 157-165
39. Casson P., Anderson R., Herrod H., et al. Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women. Am J Obstet Gynecol 169 (1993) 1536-1539
40. Young J., Couzinet B., Nahoul K., et al. Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans. J Clin Endocrin Metab 82 (1997) 2578-2585
41. Casson P., Faquin L., Stentz F., et al. Replacement of dehydroepiandrosterone enhances T-lymphocyte insulinebinding in postmenopausal women. Fertil Steril 63 (1995) 1027-1031
42. Simon J. Safety of estrogen/androgen regimens. J Reprod Med 46 3 Suppl (2001) 281-390
43. PDR 2005.