메뉴 건너뛰기




Volumn 57, Issue 7-8, 2009, Pages 636-639

The role of fatty acids in the treatment of ADHD

Author keywords

ADHD; Docosahexaenoic acid; n 3 polyunsaturated fatty acid

Indexed keywords

ALPHA TOCOPHEROL; ARACHIDONIC ACID; ASCORBIC ACID; CENTRAL STIMULANT AGENT; DOCOSAHEXAENOIC ACID; ESSENTIAL FATTY ACID; FATTY ACID DERIVATIVE; FISH OIL; GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LINOLENIC ACID; LONG CHAIN FATTY ACID; MINERAL OIL; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PLACEBO; POLYUNSATURATED FATTY ACID; THYME OIL;

EID: 70350218840     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.08.012     Document Type: Review
Times cited : (20)

References (34)
  • 3
    • 0030638716 scopus 로고    scopus 로고
    • Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD
    • Barkley R.A. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol. Bull. 121 (1997) 65-94
    • (1997) Psychol. Bull. , vol.121 , pp. 65-94
    • Barkley, R.A.1
  • 4
    • 0021238259 scopus 로고
    • Alterations in the fatty acid composition of rat brain cells (neurons, astrocytes, and oligodendrocytes) and of subcellular fractions (myelin and synaptosomes) induced by a diet devoid of n-3 fatty acids
    • Bourre J.-M., Pascal G., Durand G., Masson M., Dumont O., and Piciotti M. Alterations in the fatty acid composition of rat brain cells (neurons, astrocytes, and oligodendrocytes) and of subcellular fractions (myelin and synaptosomes) induced by a diet devoid of n-3 fatty acids. J. Neurochem. 43 (1984) 342-348
    • (1984) J. Neurochem. , vol.43 , pp. 342-348
    • Bourre, J.-M.1    Pascal, G.2    Durand, G.3    Masson, M.4    Dumont, O.5    Piciotti, M.6
  • 5
    • 0024788867 scopus 로고
    • The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats
    • Bourre J.-M., Francois M., Youyou A., Dumont O., Piciotti M., Pascal G., and Durand G. The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. J. Nutr. 119 (1989) 1880-1892
    • (1989) J. Nutr. , vol.119 , pp. 1880-1892
    • Bourre, J.-M.1    Francois, M.2    Youyou, A.3    Dumont, O.4    Piciotti, M.5    Pascal, G.6    Durand, G.7
  • 6
    • 33749143454 scopus 로고    scopus 로고
    • Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder
    • Brookes K.J., Chen W., Xu X., Taylor E., and Asherson P. Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder. Biol. Psychiatry 60 (2006) 1053-1061
    • (2006) Biol. Psychiatry , vol.60 , pp. 1053-1061
    • Brookes, K.J.1    Chen, W.2    Xu, X.3    Taylor, E.4    Asherson, P.5
  • 7
    • 0033957954 scopus 로고    scopus 로고
    • Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder
    • Burgess J.R., Stevens L., Zhang W., and Peck L. Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. Am. J. Clin. Nutr. 71 suppl (2000) 327S-330S
    • (2000) Am. J. Clin. Nutr. , vol.71 , Issue.SUPPL
    • Burgess, J.R.1    Stevens, L.2    Zhang, W.3    Peck, L.4
  • 8
    • 33748972432 scopus 로고    scopus 로고
    • Omega-3 fatty acids and monoamine neurotransmission
    • Chalon S. Omega-3 fatty acids and monoamine neurotransmission. Prostaglandins Leukot. Essent. Fatty Acids 75 (2006) 259-269
    • (2006) Prostaglandins Leukot. Essent. Fatty Acids , vol.75 , pp. 259-269
    • Chalon, S.1
  • 9
    • 0019859261 scopus 로고
    • A lack of essential fatty acid as a possible cause of hyperactivity in children
    • Colquhoun I., and Bunday S. A lack of essential fatty acid as a possible cause of hyperactivity in children. Med. Hypotheses 7 (1981) 673-679
    • (1981) Med. Hypotheses , vol.7 , pp. 673-679
    • Colquhoun, I.1    Bunday, S.2
  • 11
    • 1842527941 scopus 로고    scopus 로고
    • Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder - a placebo-controlled double-blind study
    • Hirayama S., Hamazaki T., and Terasawa K. Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder - a placebo-controlled double-blind study. Eur. J. Clin. Nutr. 58 (2004) 467-473
    • (2004) Eur. J. Clin. Nutr. , vol.58 , pp. 467-473
    • Hirayama, S.1    Hamazaki, T.2    Terasawa, K.3
  • 12
    • 60449088923 scopus 로고    scopus 로고
    • Omega-3/Omega-6 fatty acids for attention deficit hyperactivity disorder
    • 10.1177/1087054708316261
    • Johnson M., Ostlund S., Fransson G., Kadesjö B., and Gillberg C. Omega-3/Omega-6 fatty acids for attention deficit hyperactivity disorder. J. Attention Disord (2009) 10.1177/1087054708316261
    • (2009) J. Attention Disord
    • Johnson, M.1    Ostlund, S.2    Fransson, G.3    Kadesjö, B.4    Gillberg, C.5
  • 14
    • 0036689366 scopus 로고    scopus 로고
    • Reversibility of n-3 fatty acid deficiency-induced changes in dopaminergic neurotransmission in rats: critical role of developmental stage
    • Kodas E., Vancassel S., Lejeune B., Guilloteau D., and Chalon S. Reversibility of n-3 fatty acid deficiency-induced changes in dopaminergic neurotransmission in rats: critical role of developmental stage. J. Lipid Res. 43 (2002) 1209-1219
    • (2002) J. Lipid Res. , vol.43 , pp. 1209-1219
    • Kodas, E.1    Vancassel, S.2    Lejeune, B.3    Guilloteau, D.4    Chalon, S.5
  • 16
    • 84883454279 scopus 로고    scopus 로고
    • Available at:, Oregon Health & Science University, Portland, OR (2007) (accessed16.10.08)
    • McDonagh M.S. Drug Class Review on Pharmacologic Treatments for ADHD. Available at: (2007), Oregon Health & Science University, Portland, OR. http://www.ncbi.nlm.nih.gov/books/bookres.fcgi/adhd/pdfadhd.pdf (2007) (accessed16.10.08)
    • (2007) Drug Class Review on Pharmacologic Treatments for ADHD
    • McDonagh, M.S.1
  • 17
    • 0023584536 scopus 로고
    • Clinical characteristics and serum essential fatty acid levels in hyperactive children
    • Mitchell E.A., Aman M.G., Turbott S.H., and Manku M. Clinical characteristics and serum essential fatty acid levels in hyperactive children. Clin. Pediatr. 26 (1987) 406-411
    • (1987) Clin. Pediatr. , vol.26 , pp. 406-411
    • Mitchell, E.A.1    Aman, M.G.2    Turbott, S.H.3    Manku, M.4
  • 18
    • 65249100693 scopus 로고    scopus 로고
    • The influence of short-chain essential fatty acids on children with attention-deficit/hyperactivity disorder: a double-blind placebo-controlled study
    • Raz R., Carasso R.L., and Yehuda S. The influence of short-chain essential fatty acids on children with attention-deficit/hyperactivity disorder: a double-blind placebo-controlled study. J. Child. Adolesc. Psychopharmacol. 19 (2009) 167-177
    • (2009) J. Child. Adolesc. Psychopharmacol. , vol.19 , pp. 167-177
    • Raz, R.1    Carasso, R.L.2    Yehuda, S.3
  • 19
    • 67651176389 scopus 로고    scopus 로고
    • Essential fatty acids and attention-deficit-hyperactivity disorder: a systematic review
    • Raz R., and Gabis L. Essential fatty acids and attention-deficit-hyperactivity disorder: a systematic review. Dev. Med. Child Neurol. 51 (2009) 580-592
    • (2009) Dev. Med. Child Neurol. , vol.51 , pp. 580-592
    • Raz, R.1    Gabis, L.2
  • 20
    • 0036139225 scopus 로고    scopus 로고
    • A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties
    • Richardson A.J., and Puri B.K. A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Progr. Neuro-Psychopharmacol. Biol. Psychiatry 26 (2002) 233-239
    • (2002) Progr. Neuro-Psychopharmacol. Biol. Psychiatry , vol.26 , pp. 233-239
    • Richardson, A.J.1    Puri, B.K.2
  • 21
    • 20744445534 scopus 로고    scopus 로고
    • The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder
    • Richardson A.J., and Montgomery P. The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 115 (2005) 1360-1366
    • (2005) Pediatrics , vol.115 , pp. 1360-1366
    • Richardson, A.J.1    Montgomery, P.2
  • 22
    • 0030058372 scopus 로고    scopus 로고
    • Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants
    • Salem N., Wegher B., Mena P., and Uauy R. Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. Proc. Natl. Acad. Sci. U S A 93 (1996) 49-54
    • (1996) Proc. Natl. Acad. Sci. U S A , vol.93 , pp. 49-54
    • Salem, N.1    Wegher, B.2    Mena, P.3    Uauy, R.4
  • 23
    • 34247162957 scopus 로고    scopus 로고
    • Effects of supplementation with polyunsaturated fatty acids and micronutrients on ADHA-related problems with attention and behavior
    • Sinn N., and Bryan J. Effects of supplementation with polyunsaturated fatty acids and micronutrients on ADHA-related problems with attention and behavior. J. Dev. Behav. Pediatr. 28 (2007) 82-91
    • (2007) J. Dev. Behav. Pediatr. , vol.28 , pp. 82-91
    • Sinn, N.1    Bryan, J.2
  • 24
    • 51449120062 scopus 로고    scopus 로고
    • Lipid profile, fatty acid composition and pro- and anti-oxidant status in pediatric patients witj attention-deficit/hyperactivity disorder
    • Spahis S., Vanasse M., Bélanger S.A., Ghadirian P., Grenier E., and Levy E. Lipid profile, fatty acid composition and pro- and anti-oxidant status in pediatric patients witj attention-deficit/hyperactivity disorder. Prostaglandins Leukot. Essent. Fatty Acids 79 (2008) 47-53
    • (2008) Prostaglandins Leukot. Essent. Fatty Acids , vol.79 , pp. 47-53
    • Spahis, S.1    Vanasse, M.2    Bélanger, S.A.3    Ghadirian, P.4    Grenier, E.5    Levy, E.6
  • 25
    • 0029589279 scopus 로고
    • Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids
    • Sprecher H., Luthria D.L., Mohammed B.S., and Baykousheva S.P. Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids. J. Lipid Res. 36 (1995) 2471-2477
    • (1995) J. Lipid Res. , vol.36 , pp. 2471-2477
    • Sprecher, H.1    Luthria, D.L.2    Mohammed, B.S.3    Baykousheva, S.P.4
  • 26
    • 34548724398 scopus 로고    scopus 로고
    • Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder
    • Sorgi P.J., Hallowell E.M., Hutchins H.L., and Sears B. Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder. Nutr. J. 6 (2007) 16
    • (2007) Nutr. J. , vol.6 , pp. 16
    • Sorgi, P.J.1    Hallowell, E.M.2    Hutchins, H.L.3    Sears, B.4
  • 30
    • 43549118650 scopus 로고    scopus 로고
    • Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids
    • Vaisman N., Kaysar N., Zaruk-Adasha Y., Pelled D., Brichon G., Zwingelstein G., and Bodennec J. Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids. Am. J. Clin. Nutr. 87 (2008) 1170-1180
    • (2008) Am. J. Clin. Nutr. , vol.87 , pp. 1170-1180
    • Vaisman, N.1    Kaysar, N.2    Zaruk-Adasha, Y.3    Pelled, D.4    Brichon, G.5    Zwingelstein, G.6    Bodennec, J.7
  • 31
    • 0034906106 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorder
    • Voigt R.G., Llorente A.M., Jensen C.L., Fraley J.K., Berretta M.C., and Heird W.C. A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorder. J. Pediatr. 139 (2001) 189-196
    • (2001) J. Pediatr. , vol.139 , pp. 189-196
    • Voigt, R.G.1    Llorente, A.M.2    Jensen, C.L.3    Fraley, J.K.4    Berretta, M.C.5    Heird, W.C.6
  • 32
    • 0001175598 scopus 로고    scopus 로고
    • Essential Fatty Acid and Behavior
    • Yehuda S., and Mostofski D.I. (Eds), Humana Press, Totowa, New Jersey
    • Wainwright P.E. Essential Fatty Acid and Behavior. In: Yehuda S., and Mostofski D.I. (Eds). Handbook of Essential Fatty Acid Biology (1997), Humana Press, Totowa, New Jersey 299-341
    • (1997) Handbook of Essential Fatty Acid Biology , pp. 299-341
    • Wainwright, P.E.1
  • 33
    • 0023728910 scopus 로고
    • Effects of the dietary alpha-linolenate/linoleate balance on lipid compositions and learning ability of rats. II. Discrimination process, extinction process, and glycolipid compositions
    • Yamamoto N., Hashimoto A., Takemoto Y., Okuyama H., Nomura M., Kitajima R., Togashi T., and Tamai Y. Effects of the dietary alpha-linolenate/linoleate balance on lipid compositions and learning ability of rats. II. Discrimination process, extinction process, and glycolipid compositions. J. Lipid Res. 29 (1988) 1013-1021
    • (1988) J. Lipid Res. , vol.29 , pp. 1013-1021
    • Yamamoto, N.1    Hashimoto, A.2    Takemoto, Y.3    Okuyama, H.4    Nomura, M.5    Kitajima, R.6    Togashi, T.7    Tamai, Y.8
  • 34
    • 0033564615 scopus 로고    scopus 로고
    • Essential fatty acids are mediators of brain biochemistry and cognitive functions
    • Yehuda S., Rabinovitz S., and Mostofsky D.I. Essential fatty acids are mediators of brain biochemistry and cognitive functions. J. Neurosci. Res. 56 (1999) 565-570
    • (1999) J. Neurosci. Res. , vol.56 , pp. 565-570
    • Yehuda, S.1    Rabinovitz, S.2    Mostofsky, D.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.