A molecular mechanism of temperature sensitivity for mutations affecting the Drosophila muscle regulator myocyte enhancer factor-2

Genetics

Volumn 183, Issue 1, 2009, Pages 107-117

  Lovato, Tyanna L ^a   Adams, Melanie M ^a   Baker, Phillip W ^a   Cripps, Richard M ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETERODIMER; MYOCYTE ENHANCER FACTOR 2;

ADULTHOOD; ALLELE; ARTICLE; DEVELOPMENTAL STAGE; DNA BINDING; DROSOPHILA; EMBRYO; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENETIC COMPLEMENTATION; HOMOZYGOTE; IMMUNOHISTOCHEMISTRY; MOLECULAR MECHANICS; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TEMPERATURE SENSITIVITY;

ALLELES; ANIMALS; CELLS, CULTURED; DIMERIZATION; DNA; DROSOPHILA MELANOGASTER; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MODELS, BIOLOGICAL; MUSCLES; MUTATION; MYOGENIC REGULATORY FACTORS; PHENOTYPE; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE;

EID: 70350176208     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.109.105056     Document Type: Article

References (38)

1. BAKER, P., K. K. KELLY TANAKA, N. KLITGORD and R. M. CRIPPS, 2005 Adult myogenesis in Drosophila melanogaster can proceed independently of myocyte enhancer factor-2. Genetics 170: 1747-1759.
2. BAYLIES, M. K., and M. BATE, 1996 twist: A myogenic switch in Drosophila. Science 272: 1481-1484.
3. BLACK, B. L., and E. N. OLSON, 1998 Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu. Rev. Cell. Dev. Biol. 14: 167-196.
4. BLACK, B. L., and R. M. CRIPPS (Editors), 2009 Myocyte enhancer factor-2 transcription factors in heart development and disease in Heart Development and Disease. Academic Press, San Diego.
5. BOUR, B. A., M. A. O'BRIEN, W. L. LOCKWOOD, E. S. GOLDSTEIN and R. BODMER, 1995 Drosophila MEF2, a transcription factor that is essential for myogenesis. Genes Dev. 9: 730-741.
6. CARPENTER, J. M., 1950 A new semisynthetic food medium for Drosophila. Drosophila Inform. Serv. 24: 96-97.
7. CASSO, D., F.-A. RAMIREZ-WEBER and T. B. KORNBERG, 1999 GFP-tagged balancer chromosomes for Drosophila melanogaster. Mech. Dev. 88: 229-232.
8. CHAKSHUSMATHI, G., K. MONDAL, G. S. LAKSHMI, G. SINGH, A. ROY et al., 2004 Design of temperature-sensitive mutants solely from amino acid sequence. Proc. Natl. Acad. Sci. USA 101(21): 7925-7930.
9. COX, V. T., and M. K. BAYLIES, 2005 Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling. Development 132: 713-724.
10. EDGAR, R. S., and I. LIELAUSIS, 1963 Temperature-sensitive mutants of bacteriophage T4D: their isolation and genetic characterization. Genetics 49: 649-662.
11. FINCHAM, J. R. S., 1966 Genetic Complementation. W. A. Benjamin, New York.
12. GOLDSTEIN, E. S., S. L. TREADWAY, A. E. STEPHENSON, G. D. GRAMSTAD, A. KEILTY et al., 2001 A genetic analysis of the cytological region 46C-F containing the Drosophila melanogaster homolog of the jun proto-oncogene. Mol. Genet. Genomics 266: 695-700.
13. GORDON, C. L., and J. KING, 1993 Genetic properties of temperature-sensitive folding mutants of the coat protein of phage P22. Genetics 136: 427-438.
14. GULICK, T., and B. ZHU, 2004 Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity. Mol. Cell. Biol. 24(18): 8264-8275.
15. HARTWELL, L. H., J. CULOTTI and B. REID, 1970 Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc. Natl. Acad. Sci. USA 66: 352-359.
16. HAMAMORI, Y., W. U. HUNG-YI, V. SARTORELLI and L. KEDES, 1997 The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist. Mol. Cell. Biol. 17(11): 6563-6573.
17. HUANG, K., J. M. LOUIS, L. DONALDSON, F. L. LIM, A. D. SHARROCKS et al., 2000 Solution structure of the MEF2A-DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors. EMBO J. 19: 2615-2628.
18. KELLY, K. K., S. M. MEADOWS and R. M. CRIPPS, 2002 Drosophila MEF2 is a direct regulator of Actin 57B transcription in cardiac, skeletal, and visceral muscle lineages. Mech. Dev. 110(1-2): 39-50.
19. KELLY TANAKA, K. K., A. L. BRYANTSEV and R. M. CRIPPS, 2008 Myocyte enhancer factor 2 and chorion factor 2 collaborate activation of the myogenic program in Drosophila. Mol. Cell. Biol. 28(5): 1616-1629.
20. KIEHART, D. P., and R. FEGHALI, 1986 Cytoplasmic myosin from Drosophila melanogaster. J. Cell Biol. 103: 1517-1525.
21. LILLY, B., S. GALEWSKY, A. B. FIRULLI, R. A. SCHULZ and E. N. OLSON, 1994 D-MEF2: A MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis. Proc. Natl. Acad. Sci. USA 91: 5662-5666.
22. LILLY, B., B. ZHAO, G. RANGANAYAKULU, B. M. PATERSON, R. A. SCHULZ et al., 1995 Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science 267: 688-693.
23. MARTIN, J. F., J. M. MIANO, C. M. HUSTAD, N. G. COPELAND, N. A. JENKINS et al., 1994 A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. Mol. Cell. Biol. 14: 1647-1656.
24. MOLKENTIN, J. D., B. L. BLACK, J. F. MARTIN and E. N. OLSON, 1995 Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 83: 1125-1136.
25. MOLKENTIN, J. D., B. L. BLACK, J. F. MARTIN and E. N. OLSON, 1996 Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C. Mol. Cell. Biol. 16(6): 2627-2636.
26. NGUYEN, H. T., R. BODMER, S. M. ABMAYR, J. C. MCDERMOTT and N. A. SPOEREL, 1994 D-mef2: a Drosophila mesoderm-specific MADS box-containing gene with a biphasic expression profile during embryogenesis. Proc. Natl. Acad. Sci. USA 91: 7520-7524.
27. NGUYEN, T., J. B. WANG and R. A. SCHULZ, 2002 Mutations within the conserved MADS box of the D-MEF2 muscle differentiation factor result in a loss of DNA binding ability and lethality in Drosophila. Differentiation 70: 438-446.
28. PATEL, N., 1994 Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes, in Methods in Cell Biology, edited by E. A. FYRBERG and L. S. B. GOLDSTEIN. Academic Press, Boston.
29. POTTHOFF, M. J., and E. N. OLSON, 2007 MEF2: a central regulator of diverse developmental programs. Development 134(23): 4131-4140.
30. PECKHAM, M., R. M. CRIPPS, D. C. S. WHITE and B. BULLARD, 1992 Mechanics and protein content of insect flight muscles. J. Exp. Biol. 168: 57-76.
31. RANGANAYAKULU, G., B. ZHAO, A. DOKIDIS, J. D. MOLKENTIN, E. N. OLSON et al., 1995 A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila. Dev. Biol. 171: 169-181.
32. SADLER, J. R., and A. NOVICK, 1964 The properties of repressor and the kinetics of its action. J. Mol. Biol. 12: 305-327.
33. SAMBROOK, J., E. F. FRITSCH and T. MANIATIS, 1989 Molecular Cloning: A Laboratory Manual, Ed. 2. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
34. SANTELLI, E., and T. J. RICHMOND, 2000 Crystal Structure of MEF2A Core Bound to DNA at 1.5 Å Resolution. J. Mol. Biol. 297: 437-449.
35. SMITH, D. H., P. B. BERGET and J. KING, 1980 Temperature-sensitive mutants blocked in the folding or subunit assembly of the bacteriophage P22 tail-spike protein. I. Fine-structure mapping. Genetics. 2: 331-352.
36. SUNDBERG, H. A., and T. N. DAVIS, 1997 A mutational analysis identifies three functional regions of the spindle pole component Spc110p in Saccharomyces cerevisiae. Mol. Biol. Cell. 12: 2575-2590.
37. TAYLOR, M. V., K. E. BEATTY, H. K. HUNTER and M. K. BAYLIES, 1995 Drosophila MEF2 is regulated by twist and is expressed in both the primordia and differentiated cells of the embryonic somatic, visceral and heart musculature. Mech. Dev. 50: 29-41.
38. THISSE, B., M. E. MESSAL and F. PERRIN-SCHMITT, 1987 The twist gene: Isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern. Nucleic Acids Res. 15: 3439-3453.